| 黄雯婷,蒋谷芬,汪海珍,林巧梅,罗美俊子.调胃承气汤加减联合苦参汤药浴治疗斑块型银屑病（风热血燥证）疗效观察[J].现代生物医学进展英文版,2023,(13):2596-2600. |
| 调胃承气汤加减联合苦参汤药浴治疗斑块型银屑病（风热血燥证）疗效观察 |
| Curative Effect Observation of Tiaowei Chengqi Decoction Add and Subtract Combined with Kushen Decoction Medicated Bath in Treating Plaque Psoriasis (Wind-heat-blood-dryness Syndrome) |
| Received:January 27, 2023 Revised:February 24, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.13.040 |
| 中文关键词: 调胃承气汤加减 苦参汤 斑块型银屑病 风热血燥证 临床疗效 |
| 英文关键词: Tiaowei Chengqi Decoction add and subtract Kushen Decoction Plaque Psoriasis Wind-heat-blood-dryness syndrome Clinical Efficacy |
| 基金项目:湖南省中医药科研计划项目（2021187） |
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| 中文摘要: |
| 摘要 目的：观察调胃承气汤加减联合苦参汤药浴治疗斑块型银屑病（风热血燥证）临床疗效。方法：选取2020年3月~2021年3月湖南中医药大学第二附属医院收治的斑块型银屑病患者96例，按抛掷硬币法分为对照组（n=48，基础对症治疗）和观察组（n=48，在对照组基础上给予调胃承气汤加减联合苦参汤药浴综合治疗）。比较两组临床疗效、炎症反应[肿瘤坏死因子-α （TNF-α）、白细胞介素-17（IL-17）、白细胞介素-22（IL-22）]、血清血管内皮生长因子（VEGF）和转化生长因子β1（TGF-β1）水平、银屑病皮损面积、严重程度指数（PASI）和瘙痒程度及不良反应。结果：与对照组77.08%比较，观察组总有效率93.75%更高（P<0.05）。两组治疗后IL-17、TNF-α、IL-22水平及PASI、瘙痒程度评分均较治疗前降低，且观察组较对照组低（P<0.05）。两组治疗后VEGF和TGF-β1水平均较治疗前降低，且观察组较对照组低（P<0.05）。观察组不良反应总发生率为10.42%略高于对照组4.17%，经比较两组无统计学差异（P>0.05）。结论：针对斑块型银屑病患者而言，调胃承气汤加减联合苦参汤综合治疗具有较好的临床疗效，可减轻炎症反应，预防纤维化和抑制血管新生，改善PASI评分和瘙痒程度，安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical effect of Tiaowei Chengqi Decoction add and subtract combined with Kushen Decoction medicated bath in treating plaque psoriasis (wind-heat-blood-dryness syndrome). Methods: A total of 96 patients with plaque psoriasis who were treated in the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine from March 2020 to March 2021 were selected and divided into control group (n=48, basic symptomatic treatment) and observation group (n=48, given Tiaowei Chengqi Decoction add and subtract combined with Kushen Decoction combined medicated bath treatment on the basis of the control group) according to the tossing coins method. The clinical efficacy, inflammatory response [tumor necrosis factor-α(TNF-α), interleukin-17(IL-17), interleukin-22(IL-22)], serum vascular endothelial growth factor(VEGF) and transforming growth factor β1(TGF-β1) levels, psoriasis area, severity index(PASI) and degree of pruritus, and adverse reactions in the two groups were compared. Results: Compared with 77.08% in the control group, the total effective rate 93.75% in the observation group was higher(P<0.05). The IL-17, TNF-α, IL-22 levels, PASI and pruritus degree in both groups after treatment were lower than those before treatment, and the observation group was lower than the control group (P<0.05). VEGF and TGF-β1 levels in both groups after treatment were decreased than those before treatment, and the observation group was lower than the control group(P<0.05). The total incidence of adverse reactions in the observation group was 10.42%, which was slightly higher than that in the control group(4.17%), and after comparison, there was no statistical difference between the two groups(P>0.05). Conclusion: For patients with plaque psoriasis, comprehensive treatment of Tiaowei Chengqi Decoction add and subtract combined with Kushen Decoction has a good clinical effect, can reduce inflammation, prevent fibrosis and inhibit neovascularization, improve PASI score and itching degree,with good security. |
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