| 戴 红,李慎义,龙湘党,刘 亮,杨继辉,付致远.超声造影定量参数联合血清TSH、Tg、外周血NLR在甲状腺结节良恶性诊断中的应用价值[J].现代生物医学进展英文版,2023,(11):2094-2097. |
| 超声造影定量参数联合血清TSH、Tg、外周血NLR在甲状腺结节良恶性诊断中的应用价值 |
| Application Value of Contrast-Enhanced Ultrasound Quantitative Parameters Combined with Serum TSH, Tg, Peripheral Blood NLR in the Diagnosis of Benign and Malignant Thyroid Nodules |
| Received:October 26, 2022 Revised:November 22, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.11.018 |
| 中文关键词: 甲状腺结节 超声造影 TSH Tg NLR 鉴别诊断 |
| 英文关键词: Thyroid nodules Contrast-enhanced ultrasound TSH Tg NLR Differential diagnosis |
| 基金项目:湖南省卫生健康委员会一般科研项目（202209023291） |
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| 中文摘要: |
| 摘要 目的：探讨超声造影定量参数联合血清促甲状腺激素（TSH）、甲状腺球蛋白（Tg）、外周血中性粒细胞与淋巴细胞比值（NLR）在甲状腺结节良恶性诊断中的应用价值。方法：选取2020年7月到2022年5月我院收治的80例甲状腺结节患者，根据病理学检查结果将其分为良性组(53例）和恶性组（27例）。所有甲状腺结节患者均行甲状腺超声造影并记录定量参数，检测血清TSH、Tg水平，计算NLR。以术后病理结果为准，采用受试者工作特征（ROC）曲线分析超声造影定量参数、血清TSH、Tg及NLR鉴别诊断甲状腺良恶性结节的价值。结果：经组织病理学确诊恶性甲状腺结节27例，良性甲状腺结节53例。恶性组超声造影定量参数平均渡越时间(mTT)、曲线下面积（AUCceus）低于良性组（P＜0.05），血清TSH、Tg水平及NLR均高于良性组（P＜0.05）。超声造影定量参数mTT、AUCceus联合血清TSH、Tg及NLR鉴别诊断良恶性甲状腺结节的曲线下面积高于以上五项指标单独诊断。结论：恶性甲状腺结节患者超声造影定量参数mTT、AUCceus降低，且血清TSH、Tg水平及NLR增高，超声造影定量参数mTT、AUCceus联合血清TSH、Tg及NLR可提高鉴别诊断良恶性甲状腺结节的效能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the application value of contrast-enhanced ultrasound quantitative parameters combined with serum thyroid stimulating hormone (TSH), thyroglobulin (Tg), peripheral blood neutrophil to lymphocyte ratio (NLR) in the diagnosis of benign and malignant thyroid nodules. Methods: 80 patients with thyroid nodules who were admitted to our hospital from July 2020 to May 2022 were selected, and they were divided into benign group (53 cases) and malignant group (27 cases) according to pathological examination results. Quantitative parameters were recorded by thyroid contrast-enhanced ultrasound in all patients, serum TSH and Tg levels were detected, and NLR was calculated. Based on postoperative pathological results,receiver operating characteristic (ROC) curve was used to analyze the value of contrast-enhanced ultrasound quantitative parameters, serum TSH, Tg and NLR in differentiating benign and malignant thyroid nodules. Results: 27 cases of malignant thyroid nodules were confirmed by histopathology, and benign thyroid nodules had 53 cases. The contrast-enhanced ultrasound quantitative parameters of mean transit time (mTT) and area under curve (AUCceus) in the malignant group were lower than those in the benign group(P<0.05), while the serum TSH, Tg levels and NLR were higher than those in the benign group(P<0.05). The area under the curve of differential diagnosis of benign and malignant thyroid nodules by quantitative parameters of contrast-enhanced ultrasound (mTT, AUCceus) combined with serum TSH, Tg and NLR was higher than that of the above five indicators alone. Conclusion: In patients with malignant thyroid nodules, the contrast-enhanced ultrasound quantitative parameters of mTT, AUCceus are decreased, and the serum TSH, Tg levels and NLR are increased. The contrast-enhanced ultrasound quantitative parameters of mTT, AUCceus combined with serum TSH, Tg and NLR could improve the efficacy of differential diagnosis of benign and malignant thyroid nodules. |
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