| 武金盼,陈继军,赵新春,袁 青,杨卫平.丹参素注射液对急性心肌梗死大鼠的心室重构、心室功能及肢体导联与胸导联心电图参数的影响[J].现代生物医学进展英文版,2023,(11):2014-2018. |
| 丹参素注射液对急性心肌梗死大鼠的心室重构、心室功能及肢体导联与胸导联心电图参数的影响 |
| Effects of Danshusu Injection on Ventricular Remodeling, Ventricular Function and Electrocardiogram Parameters of Limb Lead and Chest Lead in Rats with Acute Myocardial Infarction |
| Received:December 05, 2022 Revised:December 28, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.11.003 |
| 中文关键词: 丹参素注射液 急性心肌梗死 心室重构 心室功能 肢体导联与胸导联心电图 |
| 英文关键词: Danshensu injection Acute myocardial infarction Ventricular remodeling Ventricular function Limb lead and chest lead electrocardiogram |
| 基金项目:陕西省社会发展科技攻关项目（S2018-YF-YBSF-0581） |
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| 中文摘要: |
| 摘要 目的：探讨丹参素注射液对急性心肌梗死大鼠的心室重构、心室功能及肢体导联与胸导联心电图参数的影响。方法：选择SD大鼠40只，将其鼠随机模型组、假手术组、硝酸甘油组、丹参注射液组。假手术组大鼠给予只在冠状动脉处穿针，不进行结扎，其余步骤同其余3组，其余3组均进行动物模型构建。假手术组、模型组大鼠均腹腔注射氯化钠注射液，硝酸甘油组腹腔注射硝酸甘油，丹参注射液组腹腔注射丹参注射液。对比4组大鼠的肢体导联与胸导联心电图参数，对比4组大鼠的血液流变学指标、左心室功能及左心室重构。结果：模型组的Ⅰ、Ⅱ、Ⅲ、aVL、aVF、V1、V2、V5、血浆粘度、纤维蛋白原、红细胞聚集指数、舒张末期室间隔厚度、左室舒张末期内径、左室收缩末期内径、左室舒张末期容积、左室收缩末期容积明显较假手术组、硝酸甘油组、丹参注射液组高，硝酸甘油、丹参注射液组以上指标明显较假手术组高，模型组的的左室舒张末期厚度、左室射血分数、左室短轴缩短率明显较假手术组、硝酸甘油组、丹参注射液组低，硝酸甘油、丹参注射液组的左室舒张末期厚度、左室射血分数、左室短轴缩短率明显较假手术组低。模型组的左心室重量指数、左心室截面直径明显较假手术组、硝酸甘油组、丹参注射液组高，硝酸甘油、丹参注射液组的左心室重量指数、左心室截面直径、梗死面积明显较假手术组高（P<0.05），硝酸甘油组与丹参注射液组以上指标对比无差异（P>0.05）。结论：丹参素注射液可改善急性心肌梗死大鼠的心室重构、左心室功能及肢体导联与胸导联心电图参数，可能与其可降低大鼠的血液流变学指标水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Danshusu injection on ventricular remodeling, ventricular function and electrocardiogram parameters of limb lead and chest lead in rats with acute myocardial infarction. Methods: 40 SD rats were randomly assigned to model group, sham operation group, nitroglycerin group and salvia miltiorrhiza injection group. In the sham operation group, only the coronary artery was pierced without ligation. The other steps were the same as those in the other 3 groups, and the animal model was constructed in the other 3 groups. The sham operation group and model group were intraperitoneally injected with sodium chloride injection, nitroglycerin group intraperitoneally injected with nitroglycerin, and salvia miltiorrhiza injection group intraperitoneally injected with salvia miltiorrhiza injection. The ECG parameters of limb lead and chest lead were compared, and the hemorheology indexes, left ventricular function and left ventricular remodeling were compared. Results: The values of Ⅰ, Ⅱ, Ⅲ, aVL, aVF, V1, V2, V5, plasma viscosity, fibrinogen, RBC aggregation index, end-diastolic septal thickness, end-diastolic left ventricular diameter, end-systolic left ventricular diameter, end-diastolic left ventricular volume and end-systolic left ventricular volume in model group were higher than those in sham operation group, nitroglycerin group and salviorrhix injection group. The above indexes in nitroglycerin and salviorrhiza injection groups were higher than those in sham operation group. The left ventricular end diastolic thickness, left ventricular ejection fraction and left ventricular short axis shortening rate in the model group were lower than those in the sham operation group, nitroglycerin group and Danshen injection group. The left ventricular end diastolic thickness, left ventricular ejection fraction and left ventricular short axis shortening rate in nitroglycerin and salviorrhix injection groups were lower than those in sham operation group. The left ventricular mass index and left ventricular cross section diameter of the model group were higher than those of the sham operation group, nitroglycerin group and salviorrhiza injection group. The left ventricular mass index, left ventricular cross section diameter and infarct area in nitroglycerin and salviorrhiza injection groups were significantly higher than those in sham operation group (P<0.05). There was no statistical significance between nitroglycerin group and Danshen injection group(P>0.05). Conclusion: Danshusu injection can improve ventricular remodeling, left ventricular function and ECG parameters of limb lead and chest lead in rats with acute myocardial infarction, which may be related to reducing the level of hemorheological indexes in rats. |
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