| 房红娟,童仁香,姚 超,赵 伟,王 涛.喜炎平注射液联合孟鲁司特钠治疗小儿急性支气管炎的疗效及对炎症细胞因子和细胞免疫功能的影响[J].现代生物医学进展英文版,2023,(10):1979-1982. |
| 喜炎平注射液联合孟鲁司特钠治疗小儿急性支气管炎的疗效及对炎症细胞因子和细胞免疫功能的影响 |
| Efficacy of Xiyanping Injection Combined with Montelukast Sodium in the Treatment of Children with Acute Bronchitis and its Influence on Inflammatory Cytokines and Cellular Immune Function |
| Received:December 07, 2022 Revised:December 30, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.10.034 |
| 中文关键词: 喜炎平注射液 孟鲁司特钠 小儿急性支气管炎 疗效 炎症细胞因子 细胞免疫功能 |
| 英文关键词: Xiyanping injection Montelukast sodium Children with acute bronchitis Efficacy Inflammatory cytokines Cellular immune function |
| 基金项目:安徽省卫健委基金资助项目（2016ek005） |
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| 中文摘要: |
| 摘要 目的：探讨孟鲁司特钠与喜炎平注射液联合治疗对小儿急性支气管炎炎症细胞因子、细胞免疫功能的影响。方法：选取2021年1月到2022年4月合肥市第二人民医院儿科收治的小儿急性支气管炎180例，按随机数字表法将全部患儿分为对照组和观察组各90例。在常规治疗的基础上，对照组接受孟鲁司特钠颗粒治疗，观察组接受喜炎平注射液联合孟鲁司特钠颗粒治疗。对比两组疗效、症状缓解情况、炎症细胞因子、细胞免疫功能指标和不良反应发生情况。结果：观察组的临床总有效率较对照组明显升高（P<0.05）。观察组的临床症状（退热、咳嗽、肺部啰音）消失时间均短于对照组（P<0.05）。两组治疗后血清超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）、降钙素原（PCT）水平均下降，且观察组均低于对照组（P<0.05）。两组治疗后CD8+下降，且观察组低于对照组；CD3+、CD4+、CD4+/CD8+升高，且观察组高于对照组（P<0.05）。两组均未出现严重不良反应。结论：孟鲁司特钠治疗联合喜炎平注射液治疗小儿急性支气管炎，可缩短临床症状（退热、咳嗽、肺部啰音）消失时间，可能与调节炎症细胞因子水平、改善机体细胞免疫功能有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Xiyanping injection combined with montelukast sodium in the treatment of children with acute bronchitis and its influence on inflammatory cytokines and cellular immune function. Methods: 180 cases of children with acute bronchitis who were admitted to the Department of Pediatrics of Hefei Second People's Hospital from January 2021 to April 2022 were selected, and they were divided into control group and observation group with 90 cases in each group according to random number table method. On the basis of conventional treatment, the control group was treated with montelukast sodium granules, and the observation group was treated with Xiyanping injection combined with montelukast sodium granules. The efficacy, symptom relief situation, inflammatory cytokines, cellular immune function indexes and the occurrence of adverse reactions were compared in the two groups. Results: Compared with the total clinical effective rate of 87.78% in the control group, 96.67% in the observation group was higher(P<0.05). The antipyretic time, cough disappearance time and lung rale disappearance time of children in the observation group were shorter than those in the control group(P<0.05). After treatment, the levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6(IL-6) and procalcitonin (PCT) in the two groups decreased, and the observation group was lower than the control group (P<0.05). After treatment, CD8+ in the two groups decreased, and the observation group was lower than the control group. CD3+, CD4+, CD4+/CD8+ increased, and the observation group was higher than the control group(P<0.05). There were no serious adverse reactions in the two groups. Conclusion:: Xiyanping injection combined with montelukast sodium in the treatment of children with acute bronchitis can improve the clinical therapeutic effect, which may be related to regulating the level of inflammatory cytokines and improving the cellular immune function of the body. |
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