| 陈艳蓉,石 赟,王 珊,窦丽阳,陈 颖.老年慢性阻塞性肺疾病急性加重期患者血清CTRP-4、CTRP-6、CTRP-9与肺功能和炎症因子的相关性分析[J].现代生物医学进展英文版,2023,(10):1857-1861. |
| 老年慢性阻塞性肺疾病急性加重期患者血清CTRP-4、CTRP-6、CTRP-9与肺功能和炎症因子的相关性分析 |
| Correlation Analysis of Serum CTRP-4, CTRP-6 and CTRP-9 with Lung Function and Inflammatory Factors in Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| Received:November 23, 2022 Revised:December 19, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.10.009 |
| 中文关键词: 老年 慢性阻塞性肺疾病 急性加重期 CTRP-4 CTRP-6 CTRP-9 肺功能 炎症因子 |
| 英文关键词: Elderly Chronic obstructive pulmonary disease Acute exacerbation CTRP-4 CTRP-6 CTRP-9 Lung function Inflammatory factors |
| 基金项目:国家自然科学基金项目（8160050038） |
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| 中文摘要: |
| 摘要 目的：探讨老年慢性阻塞性肺疾病急性加重期（AECOPD）患者血清补体C1q/肿瘤坏死因子相关蛋白4（CTRP-4）、CTRP-6、CTRP-9与肺功能和炎症因子的相关性。方法：选取2020年1月～2022年1月我院收治的117例AECOPD患者为AECOPD组，72例慢性阻塞性肺疾病稳定期（SCOPD）患者为SCOPD组，另选取同期58例体检健康者为对照组。采用酶联免疫吸附法检测血清CTRP-4、CTRP-6、CTRP-9水平，通过Pearson/Spearman相关性分析老年AECOPD患者血清CTRP-4、CTRP-6、CTRP-9与肺功能指标[第1秒用力呼气容积占预计值百分比（FEV1％）、第1秒用力呼气容积/用力肺活量（FEV1/FVC）]和炎症因子[白细胞介素（IL）-1β、IL-6、IL-8、肿瘤坏死因子-α（TNF-α）]的相关性。结果：对照组、SCOPD组、AECOPD组血清CTRP-4水平依次升高，CTRP-6、CTRP-9水平依次降低（P＜0.05）。老年AECOPD患者血清CTRP-4水平与FEV1％、FEV1/FVC呈负相关，与血清IL-1β、IL-6、IL-8、TNF-α水平呈正相关（P＜0.05）；CTRP-6、CTRP-9水平与FEV1％、FEV1/FVC呈正相关，与血清IL-1β、IL-6、IL-8、TNF-α水平呈负相关（P＜0.05）。结论：血清CTRP-4水平升高和CTRP-6、CTRP-9水平降低与老年AECOPD患者肺功能降低和炎症反应有关，可能成为老年AECOPD防治的潜在靶点。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum complement C1q/tumor necrosis factor-related protein 4 (CTRP-4), CTRP-6 and CTRP-9 with lung function and inflammatory factors in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 117 patients with AECOPD who were admitted to our hospital from January 2020 to January 2022 were selected as the AECOPD group, 72 patients with stable chronic obstructive pulmonary disease (SCOPD) were selected as the SCOPD group, and another 58 healthy people with physical examination during the same period were selected as the control group. Serum CTRP-4, CTRP-6 and CTRP-9 levels were measured by enzyme-linked immunosorbent assay, and the Pearson/Spearman correlation were used to analyze the correlation between serum CTRP-4, CTRP-6 and CTRP-9 and lung function indexes [forced expiratory volume in one second as a percentage of projected(FEV1%), forced expiratory volume in one second/forced vital capacity (FEV1/FVC)] and inflammatory factors [interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α(TNF-α)] in elderly patients with AECOPD. Results: The serum CTRP-4 level in the control group, SCOPD group and AECOPD group increased in turn, while the CTRP-6 and CTRP-9 levels decreased in turn(P＜0.05). Serum CTRP-4 level in elderly patients with AECOPD were negatively correlated with FEV1% and FEV1/FVC, and positively correlated with serum IL-1β, IL-6, IL-8, and TNF-α levels(P＜0.05). CTRP-6 and CTRP-9 levels were positively correlated with FEV1% and FEV1/FVC, and negatively correlated with serum IL-1β, IL-6, IL-8 and TNF-α levels(P＜0.05). Conclusion: The increased serum CTRP-4 level and the decreased CTRP-6 and CTRP-9 levels are associated with the decreased lung function and inflammatory response in elderly patients with AECOPD, which may be a potential target for the prevention and treatment of AECOPD in the elderly. |
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