| 赵 巍,黎 宇,雷先强,李长健,莫晓露.单核细胞趋化蛋白-1、可溶性血管细胞黏附分子-1与小儿紫癜性肾炎及其并发肾损伤的关系研究[J].现代生物医学进展英文版,2023,(9):1736-1740. |
| 单核细胞趋化蛋白-1、可溶性血管细胞黏附分子-1与小儿紫癜性肾炎及其并发肾损伤的关系研究 |
| Study on the Relationship between Monocyte Chemoattractor Protein-1,Soluble Vascular Cell Adhesion Molecule-1 and Schonlein Purpura Nephritis and Renal Injury in Children |
| Received:September 21, 2022 Revised:October 17, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.09.027 |
| 中文关键词: 小儿 紫癜性肾炎 单核细胞趋化蛋白-1 可溶性血管细胞黏附分子-1 肾损伤 |
| 英文关键词: Children Purpura nephritis Monocyte chemotactic protein-1 Soluble vascular cell adhesion molecule-1 Kidney injury |
| 基金项目:广西壮族自治区卫生健康委员会科技研究计划项目（Z20180493） |
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| 中文摘要: |
| 摘要 目的：分析单核细胞趋化蛋白-1（MCP-1）、可溶性血管细胞黏附分子-1（sVCAM-1）与小儿紫癜性肾炎及其并发肾损伤的关系。方法：选择我院在2018年1月至2020年12月期间收治的108例紫癜性肾炎患儿作为观察组，另选108例健康体检儿童作为对照组。检测两组血清MCP-1、sVCAM-1表达水平，分析紫癜性肾炎患儿血清MCP-1、sVCAM-1表达水平与肾功能指标的关系，通过受试者工作特征曲线（ROC）下面积（AUC）评价血清MCP-1联合sVCAM-1判断肾损伤的效能。结果：观察组血清MCP-1、sVCAM-1表达水平均高于对照组（P＜0.05）；观察组24 h尿蛋白定量（24 h Upro）、胱抑素C（Cys-C）、血肌酐（SCr）表达水平均高于对照组（P＜0.05）；经Pearson相关性分析，紫癜性肾炎患儿血清MCP-1、sVCAM-1表达水平均与24 h Upro、Cys-C、SCr表达水平呈正相关（P＜0.05）；在108例紫癜性肾炎患儿中，发生肾损伤34例；肾损伤组血清MCP-1、sVCAM-1表达水平均高于非肾损伤组（P＜0.05）；经ROC曲线分析，血清MCP-1联合sVCAM-1判断紫癜性肾炎患儿发生肾损伤的AUC为0.862，明显大于单一指标MCP-1的0.660和sVCAM-1的0.663（P＜0.05）。结论：紫癜性肾炎患儿血清MCP-1、sVCAM-1表达水平升高，与肾脏受累程度有关，联合判断肾损伤的效能较好，为监测病情演变提供了新的参考依据，值得临床予以重视。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between monocyte chemoattractor protein-1(MCP-1), soluble vascular cell adhesion molecule-1(sVCAM-1) and children with purpura nephritis and renal injury. Methods: 108 children with purpura nephritis admitted to our hospital from January 2018 to December 2020 were selected as the observation group, and 108 healthy children were selected as the control group. The expression levels of serum MCP-1 and sVCAM-1 in the two groups were detected, and the relationship between the expression levels of serum MCP-1 and sVCAM-1 and renal function indexes in children with purpura nephritis was analyzed. The area under the receiver operating characteristic curve (AUC) was used to evaluate the efficacy of serum MCP-1 combined with sVCAM-1 in diagnosing renal injury. Results: The expressions of MCP-1 and sVCAM-1 in the observation group were higher than those in the control group (P<0.05). The expression levels of 24 h urinary protein (24 h Upro), cystatin C (Cys-C) and serum creatinine (SCr) in the observation group were higher than those in the control group (P<0.05). Pearson correlation analysis showed that the expression levels of MCP-1 and sVCAM-1 in serum of children with purpura nephritis were positively correlated with the expression levels of Upro, Cys-C and SCr at 24 hours(P<0.05). Among 108 children with purpura nephritis, 34 had renal injury. The expression levels of MCP-1 and sVCAM-1 in the renal injury group were higher than those in the non-renal injury group (P<0.05). ROC curve analysis showed that the AUC of serum MCP-1 combined with sVCAM-1 to determine renal injury in children with purpura nephritis was 0.862, which was higher than the single index of MCP-1(0.660) and sVCAM-1(0.663) (P<0.05). Conclusion: The expression levels of MCP-1 and sVCAM-1 in serum of children with purpura nephritis are related to the degree of renal involvement, the combination of McP-1 and SVCAM-1 in the diagnosis of renal injury is effective,which provides a new reference for monitoring the evolution of the disease and is worthy of clinical attention. |
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