| 覃芳媛,王理槐,彭廷云,邓 敏,郑莹芊,魏丽萍,彭国维.雷火灸五脏背俞穴对气虚型非小细胞肺癌患者化疗后癌因性疲乏的临床疗效评价[J].现代生物医学进展英文版,2023,(8):1580-1583. |
| 雷火灸五脏背俞穴对气虚型非小细胞肺癌患者化疗后癌因性疲乏的临床疗效评价 |
| Evaluation of Clinical Effect of Thunder Fire Moxibustion on Wuzang Beiyu Point on Cancer-Related Fatigue in Patients with Non Small Cell Lung Cancer of Qi Deficiency Type after Chemotherapy |
| Received:September 23, 2022 Revised:October 17, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.08.036 |
| 中文关键词: 雷火灸 五脏背俞穴 气虚型 非小细胞肺癌 化疗 癌因性疲乏 临床疗效 |
| 英文关键词: Thunder fire moxibustion Wuzang Beiyu point Qi deficiency type Non-small cell lung cancer Chemotherapy Cancer-related fatigue Clinical effect |
| 基金项目:湖南省科技厅2020年度临床医疗技术创新引导项目（2020SK51405） |
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| 中文摘要: |
| 摘要 目的：探讨雷火灸五脏背俞穴对气虚型非小细胞肺癌（NSCLC）患者化疗后癌因性疲乏的临床疗效。方法：选取2020年3月~2022年5月期间我院收治的NSCLC患者93例，采用随机数字表法分为对照组（n=46，接受常规治疗）和观察组（n=47，在对照组的基础上接受雷火灸五脏背俞穴治疗）。对比两组简明疲乏量表（BFI）评分、中医证候积分、血液流变学指标、T淋巴细胞亚群指标、生活质量评分。结果：观察组治疗7 d后及治疗14 d后BFI评分均低于对照组同期（P<0.05）。观察组治疗14 d后腹胀纳呆、胸闷气短、神疲乏力、久嗽痰稀、浮肿便溏评分低于对照组同期（P<0.05）。观察组治疗14 d后高切全血黏度、低切全血黏度、红细胞压积、血浆黏度低于对照组同期（P<0.05）。观察组治疗14 d后CD8+低于对照组同期，CD3+、CD4+、CD4+/CD8+高于对照组同期（P<0.05）。观察组治疗14 d后功能、肺癌附加症状、生理、社会/家庭、情感评分高于对照组同期（P<0.05）。结论：雷火灸五脏背俞穴可有效减轻气虚型NSCLC患者化疗后癌因性疲乏症状，调节血液流变学水平和免疫功能，改善患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of thunder fire moxibustion on Wuzang Beiyu point on cancer-related fatigue in patients with non-small cell lung cancer (NSCLC) of qi deficiency type after chemotherapy. Methods: 93 patients with NSCLC who were admitted to our hospital from March 2020 to May 2022 were selected, and they were divided into the control group (n=46, receiving conventional treatment) and the observation group (n=47, receiving thunder fire moxibustion on Wuzang Beiyu point on the basis of the control group) by random number table method. The Brief Fatigue Inventory (BFI) score, traditional Chinese medicine syndrome score, hemorheology index, T lymphocyte subsets index and quality of life score were compared in the two groups. Results: The BFI score in the observation group at 7 d after treatment and 14 d after treatment were lower than those in the control group in the same period (P<0.05). The scores of abdominal distension and drowsiness, chest tightness and shortness of breath, fatigued spirit and lack of strength, cough and phlegm for a long time, and dropsy and loose stool in the observation group at 7 d after treatment were lower than those in the control group at the same period(P<0.05). The high shear whole blood viscosity, low shear whole blood viscosity, hematocrit, and plasma viscosity in the observation group at 14 d after treatment were lower than those in the control group at the same period (P<0.05). CD8+ in the observation group at 14 d after treatment was lower than that in the control group at the same period, and CD3+, CD4+, and CD4+/CD8+ were higher than those in the control group at the same period(P<0.05). The scores of functional, additional symptoms of lung cancer, physiological, social/family, and emotional in the observation group were higher than those in the control group at the same period (P<0.05). Conclusion: Thunder fire moxibustion on Wuzang Beiyu point can effectively reduce the symptoms of cancer-related fatigue in patients with NSCLC of qi deficiency type after chemotherapy, regulate the level of hemorheology and immune function, and improve the quality of life of patients. |
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