| 杨中纯,曾瑞芳,敬前程,石嫣然,蔡岳祥.血脂及血液流变学指标与突发性聋患者听力曲线类型的关系及其临床疗效的影响因素分析[J].现代生物医学进展英文版,2023,(8):1574-1579. |
| 血脂及血液流变学指标与突发性聋患者听力曲线类型的关系及其临床疗效的影响因素分析 |
| Relationship between Blood Lipid, Hemorheology Index and Hearing Curve Types in Patients with Sudden Sensorineural Hearing Loss and the Influencing Factors Analysis of Clinical Efficacy |
| Received:September 22, 2022 Revised:October 17, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.08.035 |
| 中文关键词: 血脂 血液流变学 突发性聋 听力曲线类型 临床疗效 影响因素 |
| 英文关键词: Blood lipid Hemorheology Sudden sensorineural hearing loss Hearing curve types Clinical efficacy Influence factor |
| 基金项目:湖南省卫生健康委员会科技计划项目（20201960）；长沙市自然科学基金项目（kq2014026） |
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| 中文摘要: |
| 摘要 目的：探究血脂及血液流变学指标与突发性聋（SSHL）患者听力曲线类型的关系，并分析临床疗效的影响因素。方法：选取2020年6月-2022年1月我院收治的103例SSHL患者设为SSHL组，另选取103例体检健康者设为健康组，分析两组血脂水平及血液流变学指标，比较不同听力曲线类型的SSHL患者血脂水平及血液流变学指标，Spearman相关分析血脂水平及血液流变学指标与SSHL患者听力曲线类型的关系，单因素和多因素Logistic回归模型分析SSHL患者临床疗效的影响因素。结果：与健康组比较，SSHL组总胆固醇（TC）、三酰甘油（TG）与全血高切、中切、低切粘度及血浆粘度明显增高（P＜0.05），高密度脂蛋白-C（HDL-C）、低密度脂蛋白-C（LDL-C）差异比较无统计学意义（P＞0.05）。不同听力曲线类型的SSHL患者各项血脂指标比较差异均无统计学意义（P＞0.05），不同听力曲线类型的SSHL患者各项血液流变学指标比较差异均有统计学意义（P＜0.05），其中全聋型患者各项血液流变学指标显著高于低频下降型患者（P＜0.05）。血脂四项与SSHL听力曲线类型无显著相关性（P＞0.05），而血液流变学指标与SSHL听力曲线类型显著相关（P<0.05）。治疗无效组患者双耳患病比例、听力曲线类型为全聋型比例、全血高切粘度、全血低切粘度、血浆粘度显著高于有效组患者（P＜0.05），多因素Logistic分析结果显示：双耳患病、听力曲线类型为全聋型、血浆粘度增加为SSHL患者治疗无效的危险因素（P＜0.05）。结论：SSHL患者存在血脂及血液流变学异常，血液流变学与SSHL患者听力曲线类型和临床疗效有一定关系，其中双耳患病、全聋型、血浆粘度增加为SSHL患者治疗无效的危险因素，检测血脂和血液流变学对于SSHL诊治具有一定临床指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between blood lipid and hemorheology indexes and hearing curve types in patients with sudden sensorineural hearing loss (SSHL), and to analyze the influencing factors of clinical efficacy. Methods: 103 patients with SSHL who were admitted to our hospital from June 2020 to January 2022 were selected as the SSHL group, and another 103 healthy people were selected as the healthy group. The blood lipid level and hemorheology indexes of the two groups were analyzed, and the blood lipid level and hemorheology indexes of the patients with different hearing curve types were compared. Spearman correlation analysis was used to analyze the relationship between the blood lipid level and hemorheology indexes and the hearing curve types of the patients with SSHL. Univariate and multivariate Logistic regression models were used to analyze the influencing factors of clinical efficacy in patients with SSHL. Results: Compared with the healthy group, the total cholesterol (TC), triacylglycerol (TG), whole blood high shear, middle shear, low shear viscosity and plasma viscosity in the SSHL group were significantly higher(P<0.05), while there were no significant differences between high density lipoprotein C (HDL-C) and low density lipoprotein C (LDL-C) (P>0.05). There was no statistically significant difference in the levels of various blood lipid indexes among different hearing curve types of patients with SSHL (P>0.05), and there was a statistically significant difference in the levels of various hemorheology indexes among different hearing curve types of patients with SSHL(P<0.05). Among them, the hemorheology indexes of patients with total deafness type were significantly higher than those of patients with low frequency decline type(P<0.05). There were no significant correlation between the four items of blood lipid and the type of SSHL hearing curve(P>0.05), while the indexes of hemorheology were significantly correlated with the type of SSHL hearing curve (P<0.05). The proportion of bilateral ear disease, the proportion of hearing curve type of total deafness, the whole blood high shear viscosity, the whole blood low shear viscosity and the plasma viscosity of patients in the ineffective group after treatment were significantly higher than those in the effective group (P<0.05). The results of multivariate Logistic analysis showed that bilateral disease, hearing curve type of total deafness, and increased plasma viscosity were risk factors for ineffective treatment in patients with SSHL (P<0.05). Conclusion: There are abnormal blood lipid and hemorheology in patients with SSHL, and hemorheology is related to the type of hearing curve and clinical efficacy in patients with SSHL. Bilateral disease, total deafness and increased plasma viscosity are risk factors for ineffective treatment in patients with SSHL. Detection of blood lipid and hemorheology has certain clinical guiding significance for diagnosis and treatment of SSHL. |
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