| 郭永忠,田 梅,叶尔买克·唐沙哈尔,张晓猛,张总刚.血清GDF-15、hs-cTnT对冠状动脉旁路移植术后新发房颤及近期主要心血管事件的预测效能研究[J].现代生物医学进展英文版,2023,(8):1536-1540. |
| 血清GDF-15、hs-cTnT对冠状动脉旁路移植术后新发房颤及近期主要心血管事件的预测效能研究 |
| Predictive Efficacy of Serum GDF-15 and hS-CTNT for New Onset Atrial Fibrillation and Recent Major Cardiac Events after Coronary Artery Bypass Grafting |
| Received:October 04, 2022 Revised:October 30, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.08.027 |
| 中文关键词: 冠心病 冠状动脉旁路移植术 生长分化因子15 高敏心肌肌钙蛋白T 房颤 主要心血管事件 |
| 英文关键词: Coronary heart disease Coronary artery bypass grafting Growth differentiation factor 15 High sensitivity cardiac troponin T Atrial fibrillation Major cardiac events |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2022D01C132） |
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| 中文摘要: |
| 摘要 目的：分析血清生长分化因子15（GDF-15）、高敏心肌肌钙蛋白T（hs-cTnT）对冠状动脉旁路移植术后新发心房颤动（房颤）及近期主要心血管事件的预测效能。方法：选择自2020年1月至2022年1月在我院行冠状动脉旁路移植术的140例冠心病患者作为研究对象，根据术后是否新发房颤，分为房颤组（46例）和非房颤组（94例）。检测两组术前血清GDF-15、hs-cTnT水平，使用多因素Logistic回归分析血清GDF-15、hs-cTnT与术后新发房颤的关系；随访6个月，观察主要心血管事件发生情况，通过受试者工作特征曲线下面积（AUC）评价血清GDF-15、hs-cTnT对术后新发房颤及近期主要心血管事件的预测效能。结果：两组患者年龄、性别、体重指数等一般资料比较无差异（P＞0.05）；房颤组SYNTAX积分高于非房颤组，差异有统计学意义(P＜0.05)；房颤组血清GDF-15、hs-cTnT水平均高于非房颤组（P＜0.05）；经多因素Logistic回归分析，SYNTAX积分、血清GDF-15、hs-cTnT均是冠状动脉旁路移植术后新发房颤的独立预测因素（P＜0.05）；经ROC曲线分析，血清GDF-15联合hs-cTnT预测冠状动脉旁路移植术后新发房颤的AUC为0.933，大于SYNTAX积分的0.790，预测近期主要心血管事件的AUC为0.925，大于SYNTAX积分的0.750（P＜0.05）。结论：血清GDF-15联合hs-cTnT对冠状动脉旁路移植术后新发房颤及近期主要心血管事件均具有良好的预测效能，值得临床予以重视。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the predictive efficacy of serum growth differentiation factor 15(GDF-15) and high-sensitivity cardiac troponin T(hS-CTNT) for new atrial fibrillation（AF）and recent major cardiac events after coronary artery bypass grafting (CABG). Methods: A total of 140 patients with coronary heart disease who underwent coronary artery bypass grafting in our hospital from January 2020 to January 2022 were selected as the research objects. According to whether they had new atrial fibrillation after surgery, they were divided into AF group (46 cases) and non-AF group (94 cases). The levels of serum GDF-15 and hs-CTnt before operation were detected in the two groups. Multivariate Logistic regression analysis was used to analyze the relationship between serum GDF-15 and hs-ctNT and postoperative new-onset atrial fibrillation. The patients were followed up for 6 months to observe the occurrence of major cardiac events. The area under the receiver operating characteristic curve (AUC) was used to evaluate the predictive efficacy of serum GDF-15 and hS-CTNT on postoperative new-onset atrial fibrillation and recent major cardiac events. Results: There was no difference in age, gender and body mass index between the two groups (P>0.05). SYNTAX score of AF group was higher than that of non-AF group (P<0.05). The serum levels of GDF-15 and hS-CTNT in AF group were higher than those in non-AF group (P<0.05). Multivariate Logistic regression analysis showed that SYNTAX score, serum GDF-15 and hS-CTNT were independent predictors of new-onset AF after CABG(P<0.05). According to ROC curve analysis, the AUC of serum GDF-15 combined with hS-CTNT in predicting new atrial fibrillation after coronary artery bypass grafting was 0.933, which was higher than the SYNTAX score of 0.790, and the AUC of predicting recent major cardiac events was 0.925, which was higher than the SYNTAX score of 0.750(P<0.05). Conclusion: Serum GDF-15 combined with hS-CTNT has good predictive efficacy for new atrial fibrillation and recent major cardiac events after coronary artery bypass grafting, which is worthy of clinical attention. |
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