| 刘骏驰,刘 旭,柳明富,刘大男,向 欣,彭 翰,刘昊楠,杨 华.颈内动脉破裂动脉瘤行支架辅助栓塞术后口服双抗治疗的时限研究[J].现代生物医学进展英文版,2023,(8):1525-1529. |
| 颈内动脉破裂动脉瘤行支架辅助栓塞术后口服双抗治疗的时限研究 |
| Time-limit Study of Oral Dual-antibody Therapy after Stent-assisted Embolization of Internal Carotid Artery Ruptured Aneurysms |
| Received:September 05, 2022 Revised:September 30, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.08.025 |
| 中文关键词: 颈内动脉破裂动脉瘤 支架辅助栓塞术 双抗治疗 |
| 英文关键词: Ruptured internal carotid artery aneurysm Stent-assisted embolization Dual-antibody therapy |
| 基金项目:贵州省科技厅科研基金项目（gzwkj2021-192）；贵州省重点学科建设项目(黔卫办发2011（52)-02) |
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| 中文摘要: |
| 摘要 目的：探讨与研究不同口服双抗治疗时限对颈内动脉破裂动脉瘤行支架辅助栓塞术后患者的影响。方法：2017年2到2022年1月选择在我院及贵州省职工医院已行颈内动脉瘤支架辅助栓塞术的患者282例作为研究对象，根据患者服药时间将其分为三组，A组、B组、C组分别术后都口服双抗治疗，持续时间分别为3个月、6个月与1年。结果：三组的手术时间、手术出血量、支架种类对比无显著差异（P>0.05）。三组术后1年的改良Rankin量表（MRS），评分都明显高于术前，A组术后1年的MRS评分都明显高于B组与C组（P<0.05）。三组术后1年的血清肿瘤坏死因子（TNF-α）与白细胞介素（IL-6）含量都明显低于术前，A组术后1年的血清TNF-α与IL-6含量也明显低于B组与C组（P<0.05）。A组术后1年的血栓、再出血事件发生率分别为2.1 %、1.1 %，都明显低于B组与C组的19.1 %、10.6 %、18.1 %、11.7 %（P<0.05）。结论：颈内动脉破裂动脉瘤行支架辅助栓塞术具有很好的应用可行性，术后短期口服双抗治疗更能改善患者的预后，降低血栓、再出血事件的发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and study the effect of different duration of oral dual-antibody therapy on patients with ruptured internal carotid artery aneurysm after stent-assisted embolization. Methods: From February 2017 to January 2022, 282 patients who had undergone stent-assisted embolization of internal carotid aneurysm in our hospital and Guizhou Provincial Workers' Hospital were selected as the research subjects. Groups and C groups were treated with oral dual-antibodies after operation, and the durations were 3 months, 6 months, and 1 year, respectively. Results: There was no difference among the three groups in terms of operative time, operative blood loss, and stent types (P>0.05). The modified Rankin scale (MRS) scores of the three groups at 6 months after surgery were higher than those before surgery, and the MRS scores of the A group at 1 year after surgery were significantly higher than those of the B group and the C group (P<0.05). The serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in the three groups at 1 year after operation. The levels were lower than those before surgery, and the serum TNF-α and IL-6 levels in the A group at 1 year after surgery were also lower than those in the B group and the C group (P<0.05). The incidences of thrombosis and rebleeding events in the A group at 1 year after operation were 1.4 % and 0.7 %, respectively, which were significantly lower than 12.9 % and 7.1 % in the B group and the C group (P<0.05). Conclusion: Stent-assisted embolization for ruptured internal carotid artery aneurysm has a good application feasibility. Short-term postoperative oral dual-antibody therapy can more effectively inhibit the expression of inflammatory factors, improve the prognosis of patients, and reduce the occurrence of thrombosis and rebleeding events. Rate. |
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