| 高 洁,刘卓超,吕 晶,赵瑞明,李永军.失眠障碍患者脑部CT影像学变化与学习记忆功能变化、临床特征相关性分析[J].现代生物医学进展英文版,2023,(7):1385-1390. |
| 失眠障碍患者脑部CT影像学变化与学习记忆功能变化、临床特征相关性分析 |
| The Correlation Analysis of Brain CT Imaging Changes with Learning and Memory Function Changes and Clinical Characteristics in Patients with Insomnia Disorder |
| Received:September 04, 2022 Revised:September 29, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.07.036 |
| 中文关键词: 失眠障碍 脑部CT 影像学变化 学习记忆功能 临床体征 |
| 英文关键词: Insomnia disorder Brain computed tomography (CT) Imaging changes Learning and memory function Clinical signs |
| 基金项目:河北省科技厅指令性计划项目（16277786D） |
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| 中文摘要: |
| 摘要 目的：探讨失眠障碍患者脑部CT影像学变化与学习记忆功能变化、临床特征相关性。方法：回顾性选择2018年6月至2021年6月来我院诊治的失眠障碍患者50例，选择同期来我院体检的健康人群30例。两组受试者均使用飞利浦64排CT进行扫描，检测计算额角指数与海马指数，对比两组受试者的额角指数、海马指数，对比两组受试者的临床记忆评分、睡眠质量评分、WCST评分，分析两组受试者的临床症状，分析观察组患者额角指数、海马指数与临床记忆评分、睡眠指数评分、WCST评分、临床症状评分的相关性。结果：观察组的额角指数、海马指数明显较对照组低（P<0.05）。观察组的临床记忆评分明显较对照组低（P<0.05）。观察组的睡眠质量评分明显较对照组低（P<0.05）。观察组的完成测验数、选择错误率、完成第一个应答数、持续错误率、错误应答数明显较对照组高，完成分类数、概念化水平百分比明显较对照组低（P<0.05）。观察组的躯体感觉评分及心理感觉评分明显较对照组高（P<0.05）。额角指数、海马指数与临床记忆评分呈正比，与睡眠质量评分、临床症状评分呈反比，与WCST评分中的完成分类数、概念化水平百分比呈正比，与WCST评分中的完成测验数、选择错误率、完成第一个应答数、持续错误率、错误应答数呈反比（P<0.05）。结论：脑部CT影像学结果发现，失眠障碍存在学习记忆功能变化，与患者的临床特征相关性、睡眠质量存在存在一定相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of brain CT imaging changes with learning and memory function changes and clinical features in patients with insomnia disorder. Methods: 50 cases with insomnia disorder from June 2018 to June 2021 and 30 healthy people who came to our hospital for physical examination during the same period were retrospectively selected. Both groups of subjects were scanned with Philips 64-slice CT, and the frontal index and hippocampal index were measured and calculated. The subjects of eminence, haima index in two groups were compared, the clinical memory score, sleep quality score, WCST scores in two groups were compared, the clinical symptoms in two groups were analyzed, the correlation of eminence, haima index and clinical memory score, sleep index score, WCST scores, clinical symptom scores in observation group was analyzed. Results: The frontal index and hippocampal index of the observation group were lower than matched group(P<0.05). The clinical memory score of the observation group was lower than matched group (P<0.05). The sleep quality score of the observation group was lower than matched group (P<0.05). Compared with the matched group, the number of completed tests, selection error rate, the number of completed first response, persistent error rate and false response in the observation group were higher, and the number of completed classification and the percentage of conceptualization level were lower in the observation group(P<0.05). The somatosensory and psychological scores of the observation group were higher than matched group(P<0.05). The eminence index, the index with clinical memory score was positively than hippocampus, and sleep quality score is inversely proportional, clinical symptom scores, and complete the classification number of WCST scores, percentage points higher than conceptual level, and the choice of number of WCST scores of completion test, error rate, the number of completed the first response, the last error rate is inversely proportional, the number of error response(P<0.05). Conclusion: Brain CT imaging results show that there are changes in learning and memory function in insomnia disorder, which are correlated with clinical characteristics and sleep quality of patients. |
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