| 杨建龙,段超勤,朱 响,孙昊尧,华婷琰.分析胃肠ESD治疗早期胃癌疗效、随访情况及血清胃蛋白酶原、癌胚抗原表达水平[J].现代生物医学进展英文版,2023,(7):1353-1357. |
| 分析胃肠ESD治疗早期胃癌疗效、随访情况及血清胃蛋白酶原、癌胚抗原表达水平 |
| Analysis of the Curative Effect, Follow-up and Serum Pepsinogen and Carcinoembryonic Antigen Expression Levels of Gastrointestinal ESD in The Treatment of Early Gastric Cancer |
| Received:July 25, 2022 Revised:August 21, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.07.030 |
| 中文关键词: 胃肠ESD 早期胃癌 疗效 随访情况 血清胃蛋白酶原 癌胚抗原 |
| 英文关键词: Gastrointestinal ESD Early gastric cancer Curative effect Follow up Serum pepsinogen Carcinoembryonic antigen |
| 基金项目:江苏省高层次卫生人才"六个一工程"拔尖人才项目（LGY2018009）；南京医科大学科技发展基金（NMUB2020264） |
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| 中文摘要: |
| 摘要 目的：分析予以早期胃癌患者胃肠内镜下黏膜剥离术（ESD）治疗的效果，为此类患者治疗提供参考。方法：于我院诊治的早期胃癌患者中筛选60例为主体，以电脑随机法将患者分成常规组（30例）、实验组（30例）。予以常规组外科切除术治疗，予以实验组胃肠ESD治疗，完成治疗后对比各组临床疗效、手术指标、血清肿瘤标志物、PG水平（PGⅠ、PGⅡ）、随访情况，病例选取时间为2019年11月-2021年11月。结果：实验组患者治疗总有效率与常规组对比无差异（P>0.05）；治疗前两组患者的CEA、CA199、CA125水无差异（P＞0.05），治疗后两组患者的CEA、CA199、CA125水平均降低，并且实验组患者降低幅度大于常规组（P＜0.05）；实验组患者的手术时间、出血量、住院时间、输血率少于或小于常规组患者相应指标（P＜0.05）；治疗前两组患者的PGⅠ、PGⅡ、PGⅠ/PGⅡ水平无差异（P＞0.05），治疗后两组患者的PGⅠ、PGⅠ/PGⅡ水平均升高，PGⅡ水平降低，实验组患者变化幅度大于常规组（P＜0.05）；实验组复发率与常规组比较无差异（P＜0.05）。结论：胃肠ESD治疗早期胃癌患者的效果较为理想，可有效改善血清蛋白酶原及肿瘤标志物水平，具有出血量少、手术时间短等优势，同时还可降低并发风险，可在此类疾病治疗中应用并推广。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the efficacy of endoscopic submucosal dissection (ESD) in the treatment of early gastric cancer, and to provide reference for the treatment of such patients. Methods: 60 patients with early gastric cancer were selected as the main body. The patients were randomly divided into routine group (30 cases) and experimental group (30 cases). The patients were treated with surgical resection in the routine group and gastrointestinal ESD in the experimental group. After treatment, the clinical efficacy, surgical indicators, serum tumor markers, PG levels (PG Ⅰ, PG Ⅱ) and follow-up were compared in each group. The case selection time was from November 2019 to November 2021. Results: There was no difference between the total effective rate of patients in the experimental group and the routine group(P>0.05); There was no difference in the levels of CEA, CA199 and CA125 between the two groups before treatment(P>0.05). After treatment, the levels of CEA, CA199 and CA125 in the two groups decreased, and the decrease in the experimental group was greater than that in the conventional group(P<0.05); The operation time, blood loss, hospitalization time and blood transfusion rate of the experimental group were less than or less than those of the conventional group(P<0.05); Before treatment, there was no difference in the levels of PG Ⅰ, PG Ⅱ and PG Ⅰ /pg Ⅱ between the two groups (P>0.05). After treatment, the levels of PG Ⅰ, PG Ⅰ /pg Ⅱ in the two groups increased, and the level of PG Ⅱ decreased. The range of change in the experimental group was greater than that in the conventional group(P<0.05); The recurrence rate of the experimental group was similar with the conventional group (P>0.05). Conclusion: the effect of gastrointestinal ESD in the treatment of patients with early gastric cancer is ideal, which can effectively improve the level of serum proteasome and tumor markers. It has the advantages of less bleeding and short operation time. At the same time, it can also reduce the risk of complications, which can be applied and promoted in the treatment of such diseases. |
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