| 陈 晨,宋文锋,刘福德,李艳波,高 凡.预后营养指数联合MPV、TC对急性前循环大血管闭塞性缺血性卒中患者血管内治疗临床结局的评估价值[J].现代生物医学进展英文版,2023,(7):1268-1273. |
| 预后营养指数联合MPV、TC对急性前循环大血管闭塞性缺血性卒中患者血管内治疗临床结局的评估价值 |
| Evaluation Value of the Prognostic Nutritional Index Combined with MPV and TC in Clinical Outcomes of Endovascular Therapy in Patients with Anterior Circulation Acute Ischemic Stroke with Large Vessel Occlusive |
| Received:October 23, 2022 Revised:November 18, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.07.013 |
| 中文关键词: 急性前循环大血管闭塞性缺血性卒中 预后营养指数 平均血小板体积 总胆固醇 预后 |
| 英文关键词: Anterior circulation acute ischemic stroke with large vessel occlusive Prognostic nutritional index Mean platelet volume Total cholesterol Prognosis |
| 基金项目:陕西省重点研发计划一般项目（2023-YBSF-408） |
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| 中文摘要: |
| 摘要 目的：探讨预后营养指数（PNI）联合平均血小板体积（MPV）、总胆固醇（TC）对急性前循环大血管闭塞性缺血性卒中（AIS-LVO）患者血管内治疗（EVT）临床结局的评估价值。方法：选取2020年1月～2022年5月我院收治的122例前循环AIS-LVO患者为研究组，根据其接受EVT后90 d临床结局分为结局不良组和结局良好组，另选取同期53名体检健康者为对照组。收集前循环AIS-LVO患者临床资料，计算PNI并检测MPV、TC水平。采用单因素和多因素Logistic回归分析前循环AIS-LVO患者接受EVT后结局不良的影响因素，受试者工作特征（ROC）曲线分析PNI、MPV、TC对前循环AIS-LVO患者接受EVT后结局不良的评估价值。结果：与对照组比较，研究组PNI降低，MPV、TC水平升高（P＜0.05）。随访90 d，122例接受EVT的前循环AIS-LVO患者结局不良发生率为36.89％（45/122）。多因素Logistic回归分析显示，年龄增加、入院美国国立卫生研究院卒中量表（NIHSS）评分及MPV、TC、低密度脂蛋白胆固醇（LDL-C）水平升高为前循环AIS-LVO患者行EVT后结局不良的独立危险因素，PNI增加为其独立保护因素（P＜0.05）。ROC曲线分析显示，PNI联合MPV、TC评估前循环AIS-LVO患者EVT后结局不良的曲线下面积大于PNI、MPV、TC单独评估。结论：前循环AIS-LVO患者PNI降低、MPV、TC水平升高与其接受EVT后结局不良密切相关，PNI联合MPV、TC评估患者行EVT后结局不良的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the evaluation value of prognostic nutritional index (PNI) combined with mean platelet volume (MPV) and total cholesterol (TC) in clinical outcomes of endovascular therapy (EVT) in patients with anterior circulation acute ischemic stroke with large vessel occlusive (AIS-LVO). Methods: 122 patients with anterior circulation AIS-LVO who were admitted to our hospital from January 2020 to May 2022 were selected as the study group. According to their clinical outcomes 90 days after receiving EVT, they were divided into poor outcome group and good outcome group, and 53 healthy subjects during the same period were selected as the control group. Clinical data of patients with anterior circulation AIS-LVO were collected, PNI was calculated, and MPV and TC levels were detected. Univariate and multivariate Logistic regression were used to analyze the influencing factors of poor outcome in patients with anterior circulation AIS-LVO after receiving EVT, and receiver operating characteristic (ROC) curve was used to analyze the evaluation value of PNI, MPV and TC on poor outcome in patients with anterior circulation AIS-LVO after receiving EVT. Results: Compared with the control group, PNI in the study group was decreased, while MPV and TC levels were increased(P＜0.05). 90d after follow-up, the incidence of poor outcome in 122 patients with anterior circulation AIS-LVO after receiving EVT was 36.89% (45/122). Multivariate Logistic regression analysis showed that increased age, admission to the National Institutes of Health Stroke Scale (NIHSS) score, and increased MPV, TC, and low-density lipoprotein cholesterol (LDL-C) levels were independent risk factors for poor outcome in patients with anterior circulation AIS-LVO after receiving EVT, the increased PNI was an independent protective factor(P＜0.05). ROC curve analysis showed that the area under curve of adverse outcome in patients with anterior circulation AIS-LVO after receiving EVT assessed by PNI combined with MPV and TC was larger than that assessed by PNI, MPV and TC alone. Conclusion: Decreased PNI and increased MPV and TC levels in patients with anterior circulation AIS-LVO are closely related to poor outcome after receiving EVT. PNI combined with MPV and TC has a higher value in evaluating poor outcome after EVT. |
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