| 郭军华,陈检明,宋志明,陈松林,易云峰.血清sCD105、Periostin、TK1在ⅢA-N2期非小细胞肺癌患者根治性切除术后复发中的临床应用价值研究[J].现代生物医学进展英文版,2023,(6):1095-1099. |
| 血清sCD105、Periostin、TK1在ⅢA-N2期非小细胞肺癌患者根治性切除术后复发中的临床应用价值研究 |
| Study on Clinical Application Value of Serum sCD105, Periostin and TK1 in the Recurrence of Patients with Stage IIIA-N2 Non-Small Cell Lung Cancer after Radical Resection |
| Received:July 21, 2022 Revised:August 18, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.06.019 |
| 中文关键词: 非小细胞肺癌 根治性切除术 复发 sCD105 Periostin TK1 预测价值 |
| 英文关键词: Non-small cell lung cancer Radical resection Recurrence sCD105 Periostin TK1 Predictive value |
| 基金项目:全军后勤科研项目（CWH17J030；CNJ14C007) |
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| 中文摘要: |
| 摘要 目的： 探讨血清可溶性CD105（sCD105）、骨膜蛋白（Periostin）、胸苷激酶1（TK1）对ⅢA-N2期非小细胞肺癌（NSCLC）患者根治性切除术后复发风险的预测价值。方法：选取2017年1月～2019年5月我院收治的127例接受根治性切除术的ⅢA-N2期NSCLC患者，根据术后3年是否复发分为复发组64例和无复发组63例，收集患者临床资料并采用酶联免疫吸附法检测血清sCD105、Periostin、TK1水平。通过多因素Logistic回归分析ⅢA-N2期NSCLC根治性切除术后复发的影响因素，受试者工作特征（ROC）曲线分析血清sCD105、Periostin、TK1水平对ⅢA-N2期NSCLC患者根治性切除术后复发的预测价值。结果：复发组血清sCD105、Periostin、TK1水平高于无复发组（P＜0.05）。复发组纵膈淋巴结转移数、隆突下淋巴结转移数、N2多站转移、N2多区域转移、N2跨区域转移比例高于无复发组（P＜0.05）。多因素Logistic回归分析显示，纵膈淋巴结转移数增加、N2跨区域转移和sCD105升高、Periostin升高、TK1升高为ⅢA-N2期NSCLC根治性切除术后复发的独立危险因素（P＜0.05）。ROC曲线分析显示，血清sCD105、Periostin、TK1单独与联合预测ⅢA-N2期NSCLC根治性切除术后复发的曲线下面积分别为0.788、0.771、0.787、0.917，三项联合预测的曲线下面积大于各指标单独预测。结论：血清sCD105、Periostin、TK1水平升高为ⅢA-N2期NSCLC患者根治性切除术后复发的独立危险因素，联合检测血清sCD105、Periostin、TK1对ⅢA-N2期NSCLC患者根治性切除术后复发的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the predictive value of serum soluble CD105 (sCD105), Periostin and thymidine kinase 1 (TK1) on the risk of recurrence of patients with stage IIIA-N2 non-small cell lung cancer (NSCLC) after radical resection. Methods: 127 patients with stage IIIA-N2 NSCLC who underwent radical resection in our hospital from January 2017 to May 2019 were selected, and they were divided into recurrence group with 64 cases and non-recurrence group with 63 cases according to whether there was recurrence 3 years after surgery. The clinical data of the patients were collected and the levels of serum sCD105, Periostin and TK1 were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the influencing factors of recurrence of stage IIIA-N2 NSCLC after radical resection. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the levels of serum sCD105, Periostin and TK1 in patients with stage IIIA-N2 NSCLC after radical resection. Results: The levels of serum sCD105, Periostin and TK1 in the recurrence group were higher than those in the non-recurrence group (P<0.05). The number of mediastinal lymph node metastasis, number of subcarinal lymph node metastasis, N2 multi-station metastasis, N2 multi-regional metastasis and N2 cross-regional metastasis ratio in the recurrence group were higher than those in the non-recurrence group (P<0.05). Multivariate Logistic regression analysis showed that increased number of mediastinal lymph node metastasis, N2 cross-regional metastasis and elevated sCD105, elevated Periostin and elevated TK1 were independent risk factors for recurrence of stage ⅢA-N2 NSCLC after radical resection (P<0.05). ROC curve analysis showed that the area under the curve of serum sCD105, Periostin and TK1 in predicting the recurrence of stage ⅢA-N2 NSCLC after radical resection were 0.788, 0.771, 0.787 and 0.917 respectively, the area under the curve of the combined prediction of the three indexes was greater than that of each index alone. Conclusion: Elevated levels of serum sCD105, Periostin and TK1 are independent risk factors for recurrence of patients with stage ⅢA-N2 NSCLC after radical resection.Combined detection of serum sCD105, Periostin and TK1 has a high predictive value for recurrence of patients with stage ⅢA-N2 NSCLC after radical resection. |
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