| 梁金才,李秉倩,朱健华,林宇驰,蒋 平.儿童先天性白内障发病的影响因素分析及人工晶状体植入术后屈光状态的变化研究[J].现代生物医学进展英文版,2023,(4):792-795. |
| 儿童先天性白内障发病的影响因素分析及人工晶状体植入术后屈光状态的变化研究 |
| Analysis of Influencing Factors of Congenital Cataract in Children and the Changes Study of Refractive State after Intraocular Lens Implantation |
| Received:June 28, 2022 Revised:July 24, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.04.037 |
| 中文关键词: 儿童 先天性白内障 影响因素 人工晶状体植入 屈光状态 |
| 英文关键词: Children Congenital cataract Influencing factors Intraocular lens implantation Refractive state |
| 基金项目:贵州省科技计划项目（黔科合LH字[2014]7301号） |
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| 中文摘要: |
| 摘要 目的：探讨儿童先天性白内障发病的影响因素，并研究人工晶状体植入（IOL）术后屈光状态的变化。方法：选择2017年4月~2019年2月期间我院收治的先天性白内障患儿98例作为病例组，选取同期来我院小儿眼科体检的健康儿童80例作为对照组。采用单因素和多因素Logistic回归分析先天性白内障发病的影响因素。病例组患儿均进行先天性白内障摘除联合IOL植入术。术后病例组患儿均随访3年，比较术后1、2、3年屈光度、眼轴长度的变化量。结果：单因素分析结果显示，先天性白内障发病与性别、孕期先兆流产、并发妊娠期高血压、并发妊娠期糖尿病、并发甲亢或甲减、贫血无关（P>0.05）。先天性白内障发病与胎龄、出生体重、先天性白内障家族史、孕前2个月或孕期是否存在感染、缺血缺氧脑病有关（P<0.05）。多因素Logistic回归分析结果显示，胎龄<37周、出生体重<2500 g、有先天性白内障家族史、孕前2个月或孕期存在感染是导致先天性白内障发病的危险因素（P<0.05）。同一时间点比较，＜2岁组术后眼轴长度增长量、屈光度变化大于2~6岁组和7~12岁组，且2~6岁组大于7~12岁组（P<0.05）。结论：胎龄<37周、出生体重<2500 g、有先天性白内障家族史、孕前2个月或孕期存在感染是导致先天性白内障发病的危险因素，此外，先天性白内障患儿接受IOL治疗后，IOL对患儿眼球发育影响较为轻微。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the influencing factors of congenital cataract in children, and to study the changes of refractive state after intraocular lens (IOL) implantation. Methods: 98 children with congenital cataract who were treated in our hospital from April 2017 to February 2019 were selected as the case group, and 80 healthy children who came to our hospital for pediatric ophthalmic examination in the same period were selected as the control group. Univariate and multivariate Logistic regression were used to analyze the influencing factors of congenital cataract. All the patients in the case group underwent congenital cataract extraction combined with IOL implantation. The patients in the case group were followed up for 3 years, and the changes of diopter and axial length at 1, 2 and 3 years after operation were compared. Results: Univariate analysis showed that the incidence of congenital cataract was not related to gender, threatened abortion during pregnancy, pregnancy induced hypertension, pregnancy induced diabetes, hyperthyroidism or hypothyroidism, anemia (P>0.05). The incidence of congenital cataract was related to gestational age, birth weight, family history of congenital cataract, whether with infection in the first 2 months before pregnancy or during pregnancy and hypoxic ischemic encephalopathy (P<0.05). Multivariate Logistic regression analysis showed that gestational age <37 weeks, birth weight <2500 g, family history of congenital cataract, infection in the first 2 months before pregnancy or during pregnancy were the risk factors for congenital cataract (P<0.05). At the same time point, the increase of axial length and the change of diopter in patients ＜ 2 years old group were greater than those in 2~6 years old group and 7~12 years old group, and those in 2~6 years old group were greater than those in 7~12 years old group (P<0.05). Conclusion: Gestational age < 37 weeks, birth weight < 2500g, family history of congenital cataract, infection in the first 2 months before pregnancy or during pregnancy are the risk factors of congenital cataract. In addition, after children with congenital cataract received IOL treatment, IOL had a slight impact on their eye development. |
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