| 秦丽欣,李 枫,白娅琴,李 妍,邓小辉.宫颈癌患者高危型人乳头瘤病毒感染状况及其与阴道微环境、氧化应激水平及Th1/Th2细胞因子的关系研究[J].现代生物医学进展英文版,2023,(4):787-791. |
| 宫颈癌患者高危型人乳头瘤病毒感染状况及其与阴道微环境、氧化应激水平及Th1/Th2细胞因子的关系研究 |
| Study on the Infection Status of High-Risk Human Papillomavirus and its Relationship with Vaginal Microenvironment, Oxidative Stress Level and Th1/Th2 Cytokines in Patients with Cervical Cancer |
| Received:June 27, 2022 Revised:July 23, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.04.036 |
| 中文关键词: 高危人乳头瘤病毒 宫颈癌 阴道微环境 氧化应激 Th1/Th2细胞因子 |
| 英文关键词: High-risk human papillomavirus Cervical cancer Vaginal microenvironment Oxidative stress Th1/Th2 cytokines |
| 基金项目:河北省2021年度医学科学研究项目（20211261） |
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| 中文摘要: |
| 摘要 目的：探讨宫颈癌患者高危型人乳头瘤病毒（HR-HPV）感染与阴道微环境、氧化应激水平及辅助性T细胞（Th）1/Th2细胞因子的关系。方法：选择2016年1月至2021年12月石家庄市妇幼保健院收治的201例宫颈癌患者，根据是否发生HR-HPV感染将患者分为HR-HPV组（84例）和非HR-HPV组（117例），另选择171例体检健康妇女为对照组。检测受试者阴道微环境（阴道清洁度、pH值、滴虫、霉菌、线索细胞和乳酸杆菌），氧化应激指标[血清总氧化态（TOS）、总还原态（TAS）、氧化应激指数（OSI）]、Th1/Th2细胞因子[白细胞介素（IL）-2、IL-4、IL-6、IL-10、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）]水平，比较上述指标的差异。结果：201例宫颈癌患者，HR-HPV 感染84例，发生率为 41.79%。HR-HPV组和非HR-HPV组阴道清洁度异常、pH值异常、滴虫阳性、霉菌阳性、线索细胞阳性检出率高于对照组（P＜0.05），乳酸杆菌阳性检出率低于对照组（P＜0.05）；HR-HPV组阴道清洁度异常、pH值异常检出率高于非HR-HPV组（P＜0.05），乳酸杆菌阳性检出率低于非HR-HPV组（P＜0.05）。HR-HPV组血清TOS、OSI、IL-4、IL-6、IL-10水平高于对照组、非HR-HPV组（P＜0.05），血清TAS、IL-2、TNF-α、IFN-γ低于对照组、非HR-HPV组（P＜0.05）。结论：宫颈癌患者存在较高的HR-HPV感染风险，HR-HPV感染可引起宫颈癌患者阴道微环境改变、氧化应激损伤以及Th1/Th2细胞因子紊乱，检测HR-HPV有助于评估宫颈癌患者阴道微生态和病情进展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between high-risk human papillomavirus (HR-HPV) infection and vaginal microenvironment, oxidative stress level and T helper cell (Th) 1/Th2 cytokines in patients with cervical cancer. Methods: 201 patients with cervical cancer who were admitted to Shijiazhuang Maternity and Child Healthcare Hospital from January 2016 to December 2021 were selected. According to whether HR-HPV infection occurred, the patients were divided into HR-HPV group (84 cases) and non-HR-HPV group (117 cases), and 171 healthy women were selected as the control group. The vaginal microenvironment (vaginal cleanliness, pH value, trichomonas, mould, cue cells and Lactobacillus), oxidative stress indicators [total oxidative state (TOS), total reduced state (TAS), oxidative stress index (OSI)], Th1/Th2 cytokines [interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ)] levels of the subjects were detected, and the differences of the above indexes were compared. Results: Among 201 patients with cervical cancer, 84 cases were infected with HR-HPV, the incidence rate was 41.79%. The detection rates of abnormal vaginal cleanliness, abnormal pH value, positive trichomonas, positive mould, and positive cue cells in the HR-HPV group and the non-HR-HPV group were higher than those in the control group (P<0.05), and the detection rate of positive Lactobacillus was lower than that in the control group (P<0.05). The detection rates of abnormal vaginal cleanliness and abnormal pH value in the HR-HPV group were higher than those in the non-HR-HPV group (P<0.05), and the positive detection rate of Lactobacillus was lower than that in the non-HR-HPV group (P<0.05). The levels of serum TOS, OSI, IL-4, IL-6 and IL-10 in the HR-HPV group were higher than those in the control group and non-HR-HPV group (P<0.05), and the levels of serum TAS, IL-2, TNF-α and IFN-γ in the HR-HPV group were lower than those in the control group and non-HR-HPV group (P<0.05). Conclusion: The patients with cervical cancer have a high risk of HR-HPV infection. HR-HPV infection can cause changes in vaginal microenvironment, oxidative stress damage and Th1/Th2 cytokine disorder in patients with cervical cancer, the detection of HR-HPV is helpful to evaluate vaginal microecology and disease progression in patients with cervical cancer. |
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