| 周婷婷,武 颖,任军丽,赵 晶,张丽娟.体外受精-胚胎移植女性患者焦虑状况的影响因素分析及对妊娠结局的影响[J].现代生物医学进展英文版,2023,(4):772-776. |
| 体外受精-胚胎移植女性患者焦虑状况的影响因素分析及对妊娠结局的影响 |
| Analysis of Influencing Factors of Anxiety State in Female Patients with in Vitro Fertilization-Embryo Transfer and its Impact on Pregnancy Outcome |
| Received:December 06, 2021 Revised:December 29, 2021 |
| DOI：10.13241/j.cnki.pmb.2023.04.033 |
| 中文关键词: 体外受精-胚胎移植 女性 焦虑状况 影响因素 妊娠结局 |
| 英文关键词: In vitro fertilization-embryo transfer Female Anxiety state Influencing factors Pregnancy outcome |
| 基金项目:江苏省科技计划项目（BE2018602） |
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| 中文摘要: |
| 摘要 目的：探讨体外受精-胚胎移植（IVF-ET）女性患者焦虑状况的影响因素及对妊娠结局的影响。方法：选择2019年3月~2021年4月期间南京鼓楼医院生殖医学科收治的192例IVF-ET女性患者。采用焦虑自评量表（SAS）评估所有患者焦虑状况。收集患者的临床资料，单因素及多因素Logistic回归分析IVF-ET女性患者焦虑的影响因素。观察不同焦虑状况患者的妊娠结局。结果：192例IVF-ET女性患者中，有37例（19.27%）患者出现焦虑状况。其中轻度焦虑15例（40.54%）、中度焦虑10例（27.03%）、重度焦虑12例（32.43%）。单因素分析结果显示，IVF-ET女性患者是否焦虑与家庭月收入、辅助生殖技术治疗失败史、文化程度、职业、不孕年限、年龄、社会支持、不孕类型、不孕原因有关（P<0.05）。多因素Logistic回归分析结果显示：不孕类型为原发不孕、不孕原因为女方因素、年龄>34岁、家庭月收入<3000元、文化程度为高中或中专及以下是导致IVF-ET女性患者发生焦虑的危险因素（P<0.05）。无焦虑患者优胚例数、2PN受精例数、获卵例数、临床妊娠例数占比均高于焦虑患者（P<0.05）。结论：IVF-ET女性患者较易产生焦虑情绪，其焦虑状况受不孕类型、不孕原因、年龄、家庭月收入、文化程度影响，且焦虑状况还会影响患者的妊娠结局，临床工作中应对存在上述影响因素的患者进行积极心理疏导。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the influencing factors of anxiety state in female patients with in vitro fertilization-embryo transfer (IVF-ET) and its impact on pregnancy outcome. Methods: 192 female patients with IVF-ET who were treated in Department of Reproductive Medicine, Nanjing Gulou Hospital from March 2019 to April 2021 were selected. The anxiety state of all patients was assessed by self-rating anxiety scale (SAS). The clinical data of the patients were collected, Univariate and multivariate Logistic regression analysis were used to analyze influence factors of anxiety in female patients with IVF-ET. The pregnancy outcome of patients with different anxiety state were observed. Results: Among 192 female patients with IVF-ET, 37 (19.27%) patients had anxiety state. There were 15 cases of mild anxiety (40.54%), 10 cases of moderate anxiety (27.03%), and 12 cases of severe anxiety (32.43%). The results of univariate analysis showed that whether anxiety of female patients with IVF-ET were related to family monthly income, failure history of assisted reproductive technology treatment, education level, occupation, infertility years, age, social support, infertility types and causes (P<0.05). Multivariate Logistic regression analysis showed that The infertility type was primary infertility, the infertility cause was female factors, age >34 years, family monthly income <3000 yuan, education level of high school or technical secondary school or below were the risk factors for anxiety state in female patients with IVF-ET (P<0.05). The proportion of optimal embryo, 2PN fertilization, egg harvesting and clinical pregnancy in non-anxiety patients were higher than those in anxiety patients (P<0.05). Conclusion: The female patients with IVF-ET are more prone to have anxiety, and their anxiety is affected by infertility type, infertility cause, age, family monthly income, education level, and anxiety state will also affect the pregnancy outcome of patients. In clinical work, patients with the above influencing factors should be actively psychological counseling. |
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