| 史潇璐,袁晓玲,高乃心,郁 佑,朱 红.沙参麦冬汤联合硫酸羟氯喹治疗气阴两虚型原发性干燥综合征的疗效及对Th17/Treg免疫失衡的影响[J].现代生物医学进展英文版,2023,(4):676-680. |
| 沙参麦冬汤联合硫酸羟氯喹治疗气阴两虚型原发性干燥综合征的疗效及对Th17/Treg免疫失衡的影响 |
| Effect of Shashen Maidong Decoction Combined with Hydroxychloroquine Sulfate in the Treatment of Primary Sjogren's Syndrome with Deficiency of Qi and Yin and its Effect on Th17/Treg Immune Imbalance |
| Received:December 28, 2021 Revised:January 24, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.04.015 |
| 中文关键词: 沙参麦冬汤 硫酸羟氯喹 气阴两虚型 原发性干燥综合征 疗效 Th17/Treg免疫失衡 |
| 英文关键词: Shashen Maidong decoction Hydroxychloroquine sulfate Deficiency of Qi and Yin Primary Sjogren's syndrome Curative effect Th17/Treg immune imbalance |
| 基金项目:江苏省中医药管理局资助项目(LZ13032) |
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| 中文摘要: |
| 摘要 目的：观察沙参麦冬汤联合硫酸羟氯喹治疗气阴两虚型原发性干燥综合征（pSS）的疗效及对辅助性T细胞（Th17）/调节性T细胞（Treg）免疫失衡的影响。方法：选择2020年3月~2021年5月期间我院收治的pSS患者80例作为研究对象，采用随机数字表法进行分组，将患者分为对照组和研究组，各为40例。对照组接受硫酸羟氯喹治疗，研究组接受沙参麦冬汤联合硫酸羟氯喹治疗。观察两组疗效、中医证候积分、症状相关指标及Th17/Treg免疫失衡指标，评价两组用药安全性。结果：研究组的临床总有效率较对照组高（P<0.05）。治疗后，两组口干咽燥、两目干涩、唇舌紫暗、关节疼痛、皮肤干涩证候积分下降，且研究组低于对照组（P<0.05）。治疗后，两组红细胞沉降率（ESR）、欧洲抗风湿病联盟干燥综合征疾病活动指数（ESSDAI）评分、免疫球蛋白G（IgG）、类风湿因子（RF）、欧洲抗风湿病联盟干燥综合征患者报告指数（ESSPRI）评分下降，且研究组低于对照组（P<0.05），基础泪液分泌Ⅰ试验（SIt）、唾液流率升高，且研究组高于对照组（P<0.05）。治疗后，两组白介素-17（IL-17）、Th17下降，白介素-10（IL-10）、Treg升高（P<0.05），研究组治疗后IL-17、Th17低于对照组，IL-10、Treg高于对照组（P<0.05）。两组不良反应发生率对比无显著性差异（P>0.05）。结论：沙参麦冬汤联合硫酸羟氯喹治疗气阴两虚型pSS疗效显著，可有效改善患者临床症状，阻止病情进展，调节机体Th17/Treg免疫失衡，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the curative effect of Shashen Maidong decoction combined with hydroxychloroquine sulfate in the treatment of primary Sjogren's syndrome (pSS) with deficiency of Qi and Yin and its effect on the helper T cells (Th17) and regulatory T cells (Treg) immune imbalance. Methods: 80 patients with pSS who were treated in our hospital from March 2020 to May 2021 were selected as the research object. The patients were randomly divided into control group and study group by computer software, with 40 cases in each group. The control group was treated with hydroxychloroquine sulfate, and the study group was treated with Shashen Maidong decoction combined with hydroxychloroquine sulfate. The curative effect, traditional Chinese medicine symptom score, symptom related indexes and Th17/Treg immune imbalance indexes of the two groups were observed. The drug safety of the two groups was evaluated. Results: The total clinical effective rate of the study group was higher than that of the control group (P<0.05). After treatment, the symptom scores of dry mouth and dry throat, two dry eyes, dark lips and tongue, joint pain and dry skin in the two groups decreased, the study group was lower than the control group (P<0.05). After treatment, erythrocyte sedimentation rate (ESR), European alliance against rheumatism Sjogren's syndrome patient reporting index (ESSDAI) score, immunoglobulin G (IgG), rheumatoid factor (RF) and European alliance against rheumatism Sjogren's syndrome patient reporting index (ESSPRI) score decreased in the two groups, and the study group was lower than the control group (P<0.05), basal tear secretionⅠtest (SIt), saliva flow rate increased, and the study group was higher than the control group (P<0.05). After treatment, interleukin-17 (IL-17), Th17 decreased, interleukin-10 (IL-10) and Treg increased in the two groups (P<0.05). After treatment, IL-17 and Th17 in the study group were lower than those in the control group, IL-10 and Treg were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Shashen Maidong decoction combined with hydroxychloroquine sulfate in the treatment of pSS with deficiency of Qi and Yin can effectively improve the clinical symptoms, prevent the progress of the disease, and improve the Th17/Treg immune imbalance. It has high clinical application value. |
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