| 贾 勤,王 慧,羽晓瑜,赵晓明,江 华.肾小球肾炎血清BUN、RBP的诊断价值分析[J].现代生物医学进展英文版,2023,(4):651-654. |
| 肾小球肾炎血清BUN、RBP的诊断价值分析 |
| Analysis of the Expression and Significance of BUN and RBP in Serum of Children with Glomerulonephritis |
| Received:July 27, 2022 Revised:August 24, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.04.010 |
| 中文关键词: 肾小球肾炎 尿素氮 视黄醇结合蛋白 诊断价值 |
| 英文关键词: Glomerulonephritis Urea nitrogen Retinol binding protein Diagnostic value |
| 基金项目:国家自然科学基金青年基金项目（81801987）；上海市浦东新区卫生和计划生育委员会卫生计生科研项目（PKJ2018-Y05） |
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| 中文摘要: |
| 摘要 目的：探讨肾小球肾炎血清中尿素氮（BUN）、视黄醇结合蛋白（RBP）的表达及意义。方法：选择2018年1月至2021年1月大华医院和我院接诊的75例肾小球肾炎患者为本研究对象，设为试验组，另选择同期在我院体检的55例作为对照组，分析血清BUN、RBP水平变化情况，及其诊断价值。结果：试验组患者血清BUN、RBP水平（15.52±1.51 mmol/L、97.87±21.28 mg/L）显著高于对照组（5.07±0.97 mmol/L、42.17±10.25 mg/L），差异显著（P＜0.05）；重度肾小球肾炎患者血清BUN、RBP水平（19.01±1.20 mmol/L、118.83±21.24 mg/L）均显著高于轻度（11.56±1.07 mmol/L、71.24±19.87 mg/L）、中度肾小球肾炎患者（14.89±1.12 mmol/L、95.75±22.13 mg/L），差异显著（P＜0.05）；中度肾小球肾炎患者血清 BUN、RBP水平（14.89±1.12 mmol/L、95.75±22.13 mg/L）均显著高于轻度肾小球肾炎患者（11.56±1.07 mmol/L、71.24±19.87 mg/L），差异显著（P＜0.05）；BUN诊断肾小球肾炎的AUC为0.866，95%CI为0.807~0.926，截断值为8.45 mmol/L；RBP诊断肾小球肾炎的AUC为0.957，95%CI为0.927~0.987，截断值为57.29 mg/L；联合检测诊断肾小球肾炎的AUC为0.991，95%CI为0.980~1.000，单独检测分别和联合检测曲线下面积比较均具有显著差异（Z=4.11、2.150，P＜0.05）；联合检测的特异度、准确度分别为93.41%、94.15%。结论：在肾小球肾炎患者中血清BUN、RBP的表达和病情严重程度之间存在着密切关系，可作为诊断肾小球肾炎的重要指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study Analysis of the Expression and significance of Urea nitrogen (BUN) and RBP in serum of children with glomerulonephritis. Methods: 75 cases of children with glomerulonephritis admitted to our hospital from January 2018 to January 2021 were selected as the subjects of this study, and 55 cases of children with glomerulonephritis who underwent physical examination in our hospital during the same period were selected as the control group. The changes of serum BUN and RBP levels and their diagnostic value were analyzed. Results: The serum BUN and RBP levels of experimental group (15.52±1.51 mmol/L, 97.87±21.28 mg/L) were significantly higher than those of control group (5.07±0.97 mmol/L, 42.17±10.25 mg/L), and the differences were significant (P<0.05). The serum BUN and RBP levels of severe glomerulonephritis (19.01±1.20 mmol/L, 118.83±21.24 mg/L) were significantly higher than those of mild glomerulonephritis (11.56±1.07mmol/L, 71.24±19.87) Mg /L), moderate glomerulonephritis (14.89±1.12mmol/L, 95.75±22.13 mg/L), the difference was significant (P<0.05); The serum BUN and RBP levels in children with moderate glomerulonephritis (14.89±1.12 mmol/L, 95.75±22.13 mg/L) were significantly higher than those in children with mild glomerulonephritis (11.56±1.07mmol/L, 71.24±19.87 mg/L), and the differences were significant (P<0.05). The AUC of GLOMERulonephritis diagnosed by BUN was 0.866, 95%CI was 0.807-0.926, and the cut-off value was 8.45 mmol/L. The AUC of RBP in diagnosing glomerulonephritis was 0.957, 95%CI was 0.927-0.987, and truncation value was 57.29 mg/L. The AUC and 95%CI for the diagnosis of glomerulonephritis were 0.991 and 0.980-1.000, respectively. There were significant differences in the area under the curve between single detection and combined detection (Z=4.11, 2.150, P<0.05). The specificity and accuracy of combined detection were 93.41% and 94.15%, respectively. Conclusion: There is a close relationship between the expression of serum BUN and RBP and the severity of the disease in children with glomerulonephritis. |
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