| 周柏村,季 欧,孙 巍,那琬琳,姚 权.槐耳颗粒联合GP方案治疗晚期非小细胞肺癌的疗效及对Th1/Th2免疫平衡和血清肿瘤标志物的影响[J].现代生物医学进展英文版,2022,(24):4777-4780. |
| 槐耳颗粒联合GP方案治疗晚期非小细胞肺癌的疗效及对Th1/Th2免疫平衡和血清肿瘤标志物的影响 |
| Efficacy of Huaier Granule Combined with GP Regimen in the Treatment of Advanced Non-Small Cell Lung Cancer and its Effect on Th1/Th2 Immune Balance and Serum Tumor Markers |
| Received:May 21, 2022 Revised:June 17, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.24.035 |
| 中文关键词: 槐耳颗粒 GP方案 晚期非小细胞肺癌 疗效 Th1/Th2免疫平衡 肿瘤标志物 |
| 英文关键词: Huaier Granule GP regimen Advanced non-small cell lung cancer Efficacy Th1/Th2 immune balance Tumor markers |
| 基金项目:四川省自然科学基金项目（2022NSFSC0691） |
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| 中文摘要: |
| 摘要 目的：观察晚期非小细胞肺癌（NSCLC）采用吉西他滨+顺铂（GP方案）联合槐耳颗粒治疗的疗效及对Th1/Th2免疫平衡和血清肿瘤标志物的影响。方法：选取2020年01月~2022年02月期间来成都市第六人民医院接受治疗的晚期NSCLC患者80例。采用双色球法将患者分为对照组（40例，GP方案治疗）和研究组（40例，槐耳颗粒联合GP方案治疗）。对比两组临床疗效、血清肿瘤标志物[糖类抗原125（CA125）、癌胚抗原（CEA）、细胞角蛋白19片段21-1（CYFRA21-1）]、Th1/Th2免疫平衡和不良反应。结果：研究组客观缓解率、疾病控制率高于对照组（P<0.05）。两组不良反应发生率组间对比无差异（P>0.05）。研究组治疗后卡式评分（KPS）、Th1、Th1/Th2高于对照组（P<0.05），Th2低于对照组（P<0.05）。治疗后研究组血清CA125、CYFRA21-1、CEA水平较对照组低（P<0.05）。结论：槐耳颗粒联合GP方案治疗晚期NSCLC，可有效降低血清CA125、CEA、CYFRA21-1水平，改善Th1/Th2免疫平衡，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the efficacy of gemcitabine combined with cisplatin (GP regimen) combined with Huaier granule in the treatment of advanced non-small cell lung cancer (NSCLC) and its effect on Th1/Th2 immune balance and serum tumor markers. Methods: 80 patients with advanced NSCLC who came to Chengdu Sixth People's Hospital for treatment from January 2020 to February 2022 were selected. The patients were divided into control group (40 cases, GP regimen treatment) and study group (40 cases, Huaier granule combined with GP regimen treatment) by double color ball method. The clinical efficacy, serum tumor markers [carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), cytokeratin 19 fragment 21-1 (CYFRA21-1)], Th1/Th2 immune balance and adverse reactions in the two groups were compared. Results: The objective remission rate and disease control rate in study group were higher than those in control group (P<0.05). There was no difference in incidence of adverse reactions in two groups (P>0.05). The Karnofsky Performance score (KPS), Th1 and Th1/Th2 in study group after treatment were higher than those in control group (P<0.05), and Th2 was lower than that in control group (P<0.05). The levels of serum CA125, CYFRA21-1 and CEA in study group after treatment were lower than those in control group (P<0.05). Conclusion: Huaier granule combined with GP regimen in the treatment of advanced NSCLC can effectively reduce the levels of serum CA125, CEA and CYFRA21-1 and improve the immune balance of Th1/Th2, which is safe and reliable. |
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