| 梁妍琰,张国栋,苏学文,卢晓颖,朱 华.口服补液盐联合米多君对小儿血管迷走性晕厥的疗效及血清电解质水平、Cor和BNP表达水平的影响[J].现代生物医学进展英文版,2022,(24):4700-4704. |
| 口服补液盐联合米多君对小儿血管迷走性晕厥的疗效及血清电解质水平、Cor和BNP表达水平的影响 |
| Effect of Oral Rehydration Salts Combined with Midodrine on Serum Electrolyte, Expression Levels of Cor and BNP in the Treatment of Vasovagal Syncope |
| Received:April 15, 2022 Revised:May 12, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.24.019 |
| 中文关键词: 血管迷走性晕厥 口服补液盐 米多君 |
| 英文关键词: Vasovagal syncope Oral rehydration salts Midodrine |
| 基金项目:内蒙古自治区自然科学基金项目（2018MS08067） |
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| 中文摘要: |
| 摘要 目的：探究口服补液盐（ORS）联合米多君对小儿血管迷走性晕厥（VVS）的疗效及血清电解质水平、皮质醇（Cor）和脑钠肽（BNP）表达水平的影响。方法：纳入2019年2月至2021年1月于我院儿科就诊的VVS患儿90例作为研究对象，采用随机数字表法将90例患儿随机分为对照组和研究组，每组45例。两组患儿均进行基础健康教育，对照组给予口服盐酸米多君片，研究组在此基础上加服ORS。比较两组患儿的临床疗效、HUTT转阴率、复发率、心率和血压变化、血清电解质水平以及血清Cor和BNP的表达水平变化，并记录研究期间两组患儿所发生的不良反应。结果：研究组总有效率高于对照组（P<0.05）。研究组总转阴率高于对照组，复发率低于对照组（P<0.05）。两组患儿治疗前后HR和SBP均无统计学差异（P＞0.05）。治疗后两组患儿的血清钠、钙、氯的浓度均显著升高，而磷、钾的浓度显著降低（P＜0.05）；与对照组相比，研究组患儿治疗后钠、钙、氯的浓度较高，而磷、钾的浓度较低（P＜0.05）。治疗后两组患儿的血清Cor和BNP的表达水平均显著降低（P＜0.05）；与对照组相比，研究组患儿治疗后均较低（P＜0.05）。两组患儿研究期间均未见明显不良反应。结论：ORS联合盐酸米多君对儿童VVS疗效显著，患儿血清电解质水平显著改善，血清Cor和BNP的表达水平均显著降低，且无明显不良反应，该治疗方案具有一定的实际应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of oral rehydration salts(ORS) combined with midodrine on serum electrolyte, expression levels of cortisol(Cor) and brain natriuretic peptide(BNP) in the treatment of vasovagal syncope(VVS). Methods: 90 VVS children admitted to department of pediatrics of our hospital from February 2019 to January 2021 were randomly divided into the matched group and research group, each group has 45 cases. Both groups were accepted with health education, the matched group was treated with midodrine, the research group was treated with midodrine combined with ORS. The clinical efficacy, negative rates, recurrence rates, HR and SBP, serum electrolyte levels, expression levels of Cor and BNP were combined, the adverse reactions during the research were recorded. Results: The total effective rate of research group was higher than matched group (P<0.05). The negative rates of research group was higher than matched group, and the recurrence rate was lower than that in the control group (P<0.05). The HR and SBP of two group before and after the treatment had no difference (P＞0.05). The levels of serum sodium, calcium and chlorine of two groups after treatment were all increased, while phosphorus, potassium were decreased (P<0.05); as compared with matched group, the levels of serum sodium, calcium and chlorine of research group after treatment were higher, while phosphorus, potassium were lower(P<0.05). The expression levels of serum Cor and BNP of two groups after treatment were all decreased(P<0.05); as compared with matched group, the expression levels of serum Cor and BNP of research group after treatment were lower(P<0.05). There was no difference of incidence of adverse reactions of two groups during the research(P＞0.05). Conclusion: ORS combined with midodrine was effective in the treatment of VVS, the serum electrolyte was improved and the expression levels of serum Cor and BNP were decreased without obvious adverse reactions. |
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