| 张凯歌,张燕子,陈 静,邢 斐,刘 茜.冠心病患者血清Alarin和Chemerin的表达水平与血管病变严重程度的相关性研究[J].现代生物医学进展英文版,2022,(24):4686-4690. |
| 冠心病患者血清Alarin和Chemerin的表达水平与血管病变严重程度的相关性研究 |
| Association of Serum Levels of Alarin and Chemerin with the Severity of Coronary Artery Disease Patients |
| Received:March 24, 2022 Revised:April 18, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.24.016 |
| 中文关键词: 冠心病 Alarin 趋化素 Gensini评分 |
| 英文关键词: Coronary heart disease Alarin Chemerin Gensini score |
| 基金项目:陕西省科技厅自然科学基础研究项目（2021JM-259） |
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| 中文摘要: |
| 摘要 目的：研究冠心病患者血清中Alarin和趋化素（Chemerin）表达水平和其血管病变严重程度的相关性。方法：随机选择2017年1月1日至2021年1月1日在本院接受冠状动脉造影检查的冠心病患者112作为研究对象，并选择86例健康体检者作为对照组。其中冠心病患者行冠状动脉造影检查，病变程度由Gensini评分确定，血清Alarin和Chemerin水平使用酶联免疫吸附试验测定。结果：与对照组健康受试者相比，冠心病患者的体重指数、收缩压、舒张压、总胆固醇、甘油三酯和低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平明显升高（P<0.05）；冠心病患者血清Alarin水平明显高于对照组（0.62±0.18 vs. 0.41±0.19 μg/L，P<0.05）。另外，冠心病患者血清Chemerin水平明显高于对照组（124.7±19.3 vs. 88.6±10.9 ng/mL，P<0.05）。血清Alarin和Chemerin水平分别与Gensini评分呈显著正相关（r=0.51，P<0.05；r=0.62，P<0.05）。多因素Logistic回归分析显示，血清Alarin和Chemerin水平是冠脉造影冠心病的独立预测因素（OR=0.91，95%CI：0.90-0.92；P<0.05和OR=0.93，95 %CI：0.90-0.95；P<0.05）。结论：本研究显示，冠心病患者血清Alarin和Chemerin水平明显高于健康受试者，且与冠心病严重程度呈显著正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum levels of alarin and chemerin and the presence and severity of coronary artery disease (CAD) in patients. Methods: The study population was constitutive of 112 CAD patients, who had performed the coronary angiography for suspecting CAD, and 86 healthy individuals as the control group. Angiographic CAD was defined as a narrowing of lumen diameter ≥50 % in at least one major epicardial coronary artery. The severity of CAD was identified by the Gensini score. Serum levels of alarin and chemerin were measured using enzyme linked immunosorbent assay (ELISA). Results: Body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, and low density lipoprotein cholesterol and high density lipoprotein cholesterol levels were significantly higher in patients with CHD compared with healthy subjects in the control group (P<0.05); Serum alarin levels was notably higher in patients with CAD (n=112) than those in the control group (n=86) (0.62±0.18 vs. 0.41±0.19 μg/L, P<0.05). In addition, patients with CAD had higher alarin levels than healthy individuals (124.7±19.3 vs. 88.6±10.9 ng/mL, P<0.05). Serum alarin and chemerin levels had the significant positive correlation with the Gensini score, respectively (r=0.51，P<0.05; r=0.62, P<0.05). Multivariate logistic regression analysis indicated that serum alarin and chemerin levels were the independent predictors for identifying the existence of angiographic CAD (OR=0.91, 95%CI: 0.90-0.92; P<0.05 and OR=0.93，95%CI: 0.90-0.95; P<0.05, respectively). Conclusion: In this study, serum alarin and chemerin levels in patients with CAD were significantly higher than those in healthy subjects, and serum alarin and chemerin levels were significantly positively correlated with the severity of CAD. |
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