| 张智翔,刘高锋,谢 非,董军强,贾 方.多层螺旋CT联合血清淀粉酶、脂肪酶、D-二聚体、糖蛋白2对急性胰腺炎的诊断价值研究[J].现代生物医学进展英文版,2022,(24):4659-4662. |
| 多层螺旋CT联合血清淀粉酶、脂肪酶、D-二聚体、糖蛋白2对急性胰腺炎的诊断价值研究 |
| Diagnostic Value Study of Multi-Slice Spiral CT Combined with Serum Amylase, Lipase, D-Dimer and Glycoprotein 2 in Acute Pancreatitis |
| Received:May 23, 2022 Revised:June 18, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.24.011 |
| 中文关键词: 急性胰腺炎 多层螺旋CT 淀粉酶 脂肪酶 D-二聚体 糖蛋白2 |
| 英文关键词: Acute pancreatitis Multislice spiral CT Amylase Lipase D-dimer Glycoprotein 2 |
| 基金项目:国家自然科学基金项目（81874051） |
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| 中文摘要: |
| 摘要 目的：研究多层螺旋CT（MSCT）联合血清淀粉酶（AMY）、脂肪酶（LPS）、D-二聚体（D-D）、糖蛋白2（GP2）对急性胰腺炎（AP）的诊断价值。方法：选取2019年1月～2022年1月我院收治的89例AP患者，记作研究组。另取同期健康体检人员80例作为健康组。对所有AP患者均开展MSCT检查，并分析相关影像学特征。比较两组血清AMY、LPS、D-D及GP2水平。以受试者工作特征（ROC）曲线分析明确MSCT联合血清AMY、LPS、D-D及GP2诊断AP的效能。结果：AP患者的MSCT影像学表现特征明显，且急性水肿型胰腺炎体积普遍正常或呈轻度增大，可见均匀强化，胰腺轮廓清晰或模糊。而急性坏死性胰腺炎以胰腺体积显著增大为主，可见不均匀强化，形态规则性较差，胰腺轮廓模糊。在血清AMY、LPS、D-D及GP2水平方面对比，研究组均高于健康组（均P＜0.05）。经ROC曲线分析发现，MSCT联合血清AMY、LPS、D-D及GP2诊断AP的曲线下面积（AUC）、灵敏度、特异度以及约登指数均高于上述五项单独诊断。结论：MSCT联合血清AMY、LPS、D-D及GP2诊断AP的效能较佳。 |
| 英文摘要: |
| ABSTRACT Objective: To study the diagnostic value of multi-slice spiral CT (MSCT) combined with serum amylase (AMY), lipase (LPS), D-dimer (D-D) and glycoprotein 2 (GP2) in acute pancreatitis (AP). Methods: 89 patients with AP who were admitted to our hospital from January 2019 to January 2022 were selected as the study group. Another 80 healthy physical examination personnel in the same period were selected as the healthy group. MSCT was performed in all patients with AP, and the relevant imaging features were analyzed. The serum levels of AMY, LPS, D-D and GP2 were compared between the two groups. The efficacy of MSCT combined with serum AMY, LPS, D-D and GP2 in diagnosing AP was determined by analyzing the receiver operating characteristic (ROC) curve. Results: The MSCT imaging features of patients with AP were obvious, and the volume of acute edematous pancreatitis was generally normal or slightly increased, with uniform enhancement and clear or fuzzy pancreatic outline. In acute necrotizing pancreatitis, the volume of pancreas increased significantly, with uneven enhancement, poor morphological regularity, and vague outline of pancreas. The levels of serum AMY, LPS, D-D and GP2 in the study group were higher than those in the healthy group (all P＜0.05). The ROC curve analysis showed that the area under the curve (AUC), sensitivity, specificity and Jordan index of MSCT combined with serum AMY, LPS, D-D and GP2 in diagnosing AP were higher than those of the above five separate diagnoses. Conclusion: MSCT combined with serum Amy, LPS, D-D and GP2 is more effective in diagnosing AP. |
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