| 赵旭伟,刘红耀,马 丁,王 超,朱联锴.术前中性粒细胞绝对值/淋巴细胞比值联合血清瘦素、睾酮对前列腺癌根治术后生化复发的评估价值[J].现代生物医学进展英文版,2022,(23):4572-4575. |
| 术前中性粒细胞绝对值/淋巴细胞比值联合血清瘦素、睾酮对前列腺癌根治术后生化复发的评估价值 |
| Evaluation Value of Preoperative Neutrophil Absolute Value / Lymphocyte Ratio Combined with Serum Leptin and Testosterone on Biochemical Recurrence after Radical Resection of Prostate Cancer |
| Received:April 30, 2022 Revised:May 25, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.23.034 |
| 中文关键词: 前列腺癌根治术 中性粒细胞绝对值/淋巴细胞比值 瘦素 睾酮 生化复发 预测价值 |
| 英文关键词: Radical resection of prostate cancer Neutrophil absolute value/lymphocyte ratio Leptin Testosterone Biochemical recurrence Predictive valuea |
| 基金项目:山西省自然科学基金项目（2016011042-2） |
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| 中文摘要: |
| 摘要 目的：探讨术前中性粒细胞绝对值/淋巴细胞比值（NLR）联合血清瘦素、睾酮对前列腺癌（PCa）根治术后生化复发的评估价值。方法：选取2018年1月～2020年1月于我院接受根治性切除术治疗的82例PCa患者。术前均检测NLR、血清瘦素、睾酮水平。术后对所有患者均进行2年随访观察，按照是否发生生化复发分为复发组（n=34）以及无复发组（n=48）。比较两组NLR、血清瘦素、睾酮水平差异。收集患者临床资料，采用多因素Logistic回归分析PCa根治术后生化复发的影响因素。采用受试者工作特征（ROC）曲线分析NLR以及血清瘦素、睾酮预测PCa根治术后生化复发的评估价值。结果：复发组术前NLR以及瘦素水平均高于无复发组（P＜0.05），而睾酮水平低于无复发组（P＜0.05）。复发组术前前列腺特异抗原（PSA）≥10 ng/mL、TNM分期T2期人数占比以及Gleason评分均高于无复发组（P＜0.05）。多因素Logistic回归分析显示，术前PSA≥10 ng/mL、TNM分期T2期、Gleason评分较高、术前NLR较高、瘦素水平较高、睾酮水平较低是PCa根治术后生化复发的危险因素（P＜0.05）。ROC曲线分析显示，联合检测术前NLR、血清瘦素、睾酮水平预测PCa根治术后生化复发的ROC曲线下面积为0.897，高于三项指标单独检测的0.678、0.712、0.733。结论：PCa根治术后生化复发受术前PSA、NLR、血清瘦素、睾酮水平、TNM分期、Gleason评分等因素影响，术前NLR联合血清瘦素、睾酮对PCa根治术后生化复发的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the evaluation value of preoperative neutrophil absolute value / lymphocyte ratio (NLR) combined with serum leptin and testosterone on biochemical recurrence after radical resection of prostate cancer (PCa). Methods: 82 patients with PCa who underwent radical resection in our hospital from January 2018 to January 2020 were select. The Level of NLR, serum leptin and testosterone were detected before operation. All patients were followed up for 2 years after operation. According to whether biochemical recurrence occurred, they were divided into recurrence group (n=34) and non recurrence group (n=48). NLR, serum leptin and testosterone levels were compared between the two groups. The clinical data of patients were collected and the influencing factors of biochemical recurrence after radical resection of PCa radical operation were analyzed by multivariate logistic regression. The evaluation value of NLR, serum leptin and testosterone in predicting biochemical recurrence after radical resection of PCa was analyzed by using receiver operating characteristi(ROC) curve. Results: The preoperative NLR and leptin levels in recurrence group were higher than those in non recurrence group(P＜0.05), The testosterone level was lower than that in recurrence group(P＜0.05). The preoperative prostate specific antigen (PSA)≥10 ng/mL, the proportion of TNM stage T2 and Gleason score in the recurrence group were higher than those in the non recurrence group(P＜0.05). Multivariate logistic regression analysis showed that preoperative PSA≥10 ng/mL, TNM stage T2, Gleason score, preoperative NLR, high leptin level and low testosterone level were the risk factors for biochemical recurrence after radical resection of PCa (P＜0.05). The area under the ROC curve of predicting biochemical recurrence after PCa radical operation by combined detection of preoperative NLR, serum leptin and testosterone levels was 0.897, which was higher than 0.678, 0.712 and 0.733 detected by three indicators alone. Conclusion: Biochemical recurrence after radical resection of PCa was affected by preoperative PSA, NLR, leptin, testosterone level, TNM stage and Gleason score, Preoperative NLR combined with serum leptin and testosterone has high predictive value for biochemical recurrence after radical resection of PCa. |
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