| 姚 艳,黄 琦,方秀丽,商 晶,黄秀敏.抗HPV生物凝胶敷料治疗慢性宫颈炎伴持续性HPV感染疗效及对患者疼痛与炎症因子表达的影响[J].现代生物医学进展英文版,2022,(23):4461-4464. |
| 抗HPV生物凝胶敷料治疗慢性宫颈炎伴持续性HPV感染疗效及对患者疼痛与炎症因子表达的影响 |
| Effect of Anti HPV Biological Gel Dressing on Chronic Cervicitis with Persistent HPV Infection and Its Effect on Pain and Inflammatory Factors Expression |
| Received:April 28, 2022 Revised:May 23, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.23.012 |
| 中文关键词: 慢性宫颈炎 持续性HPV感染 抗HPV生物凝胶敷料 |
| 英文关键词: Chronic cervicitis Persistent HPV infection Anti HPV biological gel dressing |
| 基金项目:福建省2019年自然科学基金项目（2019J01557） |
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| 中文摘要: |
| 摘要 目的：评价抗HPV生物凝胶敷料治疗慢性宫颈炎伴持续性人乳头瘤病毒（HPV）感染的疗效，并分析对患者疼痛与炎症因子的影响。方法：选入2020年5月~2022年3月我院收治的慢性宫颈炎伴持续性HPV感染患者156例，随机分为对照组和观察组，每组78例，其中对照组予以保妇康栓治疗，观察组应用抗HPV生物凝胶敷料治疗。评价两组的临床疗效、HPV转阴率、患者疼痛程度、炎症因子水平等指标，并进行统计比较。结果：治疗前，两组各项指标无明显差异（P＞0.05）；治疗后，观察组疼痛VAS评分显著低于对照组（P＜0.05）；观察组治疗后阴道灌洗液肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、白细胞介素（IL）-6和IL-4水平低于对照组（P＜0.05），γ-干扰素（IFN-γ）水平高于对照组（P＜0.05）；观察组治疗后病毒载量较对照组低，HPV转阴率较对照组高（P＜0.05）；观察组治疗总有效率96.15 %，显著高于对照组的80.77 %（P＜0.05）。结论：抗HPV生物凝胶敷料治疗慢性宫颈炎伴持续性HPV感染疗效肯定，可有效缓解疼痛症状，提高HPV转阴率，改善宫颈局部炎症状态，提升临床疗效，且安全性良好，具有临床推广价值。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the efficacy of anti HPV biological gel dressing in the treatment of chronic cervicitis with persistent human papillomavirus (HPV) infection and analyze the impact of pain and inflammatory factors on patients. Methods: 156 patients with chronic cervicitis and persistent HPV infection admitted to our hospital from May 2020 to March 2022 were randomly divided into the Matched group and the observation group, 78 cases in each group. The matched group was treated with Bao Fukang suppository, and the observation group was treated with anti HPV biological gel dressing. The clinical efficacy, HPV negative conversion rate, pain degree and inflammatory factor level of the two groups were compared. Results: Before treatment, there was no difference between the two groups (P>0.05). Post-treatment, the VAS score of pain in the observation group was lower than that in the Matched group (P<0.05). The levels of TNF-α, hsCRP, IL-6 and IL-4 in vaginal lavage fluid after treatment in the observation group were lower than those in the matched group(P<0.05), the level of IFN-γ was higher than that in the matched group (P<0.05). The observation group had lower viral load and higher HPV negative conversion rate than the matched group after treatment (P<0.05). The total effective rate of observation group was 96.15 %, higher than that of matched group 80.77 %(P<0.05). Conclusion: Anti HPV biological gel dressing is effective in treating chronic cervicitis and persistent HPV infection. It can effectively relieve pain symptoms, improve the negative rate of HPV, improve the local inflammatory state of the cervix, and improve the clinical efficacy. It is safe and has the value of clinical promotion. |
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