| 杨松杰,林晓旭,张清旭,邱雪立,吴晓滨.胫骨横向骨搬移术联合封闭引流技术治疗糖尿病足溃疡的临床比较研究[J].现代生物医学进展英文版,2022,(21):4143-4147. |
| 胫骨横向骨搬移术联合封闭引流技术治疗糖尿病足溃疡的临床比较研究 |
| Clinical Comparison Study of Transverse Tibial Bone Transfer Combined with Vacuum Sealing Drainage in the Treatment of Diabetic Foot Ulcers Transverse Tibial Bone Transfer |
| Received:May 18, 2022 Revised:June 10, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.21.026 |
| 中文关键词: 胫骨横向骨搬移术 封闭引流技术 糖尿病足溃疡 创面愈合 |
| 英文关键词: Transverse tibial bone transfer Vacuum sealing drainage Diabetic foot ulcers Wound healing |
| 基金项目:汕头市科技计划医疗卫生类别项目（181205224010719）；广东省自然科学基金项目（06024394） |
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| 中文摘要: |
| 摘要 目的：观察胫骨横向骨搬移术联合封闭引流技术（VSD）治疗糖尿病足溃疡（DFU）的治疗效果。方法：选取2018年4月~2020年7月我院收治的65例DFU患者。根据治疗方式的不同将患者分为A组（32例，VSD治疗）和B组（33例，胫骨横向骨搬移术联合VSD治疗）。对比两组围术期指标、患足皮温、视觉模拟评分法（VAS）评分、踝肱指数（ABI）和血清相关指标变化，记录两组并发症发生率。结果：两组术后1个月，患足皮温、ABI升高，VAS评分下降，且B组的变化幅度明显大于A组（P<0.05）。两组完全负重时间、下地行走时间组间对比无差异（P>0.05）。B组的溃疡愈合时间、去除外固定架时间明显短于A组（P<0.05）。两组术后1个月血管内皮生长因子（VEGF）水平升高，白细胞计数（WBC）、C反应蛋白（CRP）水平下降，且B组的变化幅度明显大于A组（P<0.05）。两组并发症发生率组间对比无统计学差异（P>0.05）。结论：胫骨横向骨搬移术联合VSD治疗DFU，可促进创面愈合，效果显著。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the therapeutic effect of transverse tibial bone transfer combined with vacuum sealing drainage (VSD) in the treatment of diabetic foot ulcers (DFU). Methods: 65 patients with DFU who were treated in our hospital from April 2018 to July 2020 were selected. According to the different treatment methods, the patients were divided into group A (32 cases, VSD treatment) and group B (33 cases, transverse tibial bone transfer combined with VSD treatment). The perioperative indexes, affected foot skin temperature, visual pain simulation (VAS) score, ankle brachial index (ABI) and serum related indexes changes were compared between the two groups, and the incidence of complications in two groups was recorded. Results: Two groups at 1 month after operation, the affected foot skin temperature and ABI increased, and the VAS score decreased, and the change range in group B was significantly greater than that in group A (P<0.05). There were no differences in complete weight-bearing time and walking time on the ground between the two groups (P>0.05). The ulcer healing time and removal time of external fixator in group B were significantly shorter than those in group A (P<0.05). Two groups at 1 month after operation, vascular endothelial growth factor (VEGF) increased, white blood cell count (WBC) and C-reactive protein (CRP) levels decreased, and the change range in group B was significantly greater than that in group A (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: Transverse tibial bone transfer combined with VSD in the treatment of DFU can promote wound healing, with remarkable effect. |
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