| 李 宁,郑红霞,邰苏豫,王 正,季 军,周家珍,李 晶.军事飞行人员非酒精性脂肪肝病患者白细胞计数、C反应蛋白、尿酸与糖脂代谢、胰岛素抵抗和肝纤维化指标的相关性研究[J].现代生物医学进展英文版,2022,(20):3962-3965. |
| 军事飞行人员非酒精性脂肪肝病患者白细胞计数、C反应蛋白、尿酸与糖脂代谢、胰岛素抵抗和肝纤维化指标的相关性研究 |
| Correlation Study between Leukocyte Count, C-reactive Protein, Uric Acid and Glucose and Lipid Metabolism, Insulin Resistance and Liver Fibrosis Indexes in Military Pilots with Nonalcoholic Fatty Liver Disease |
| Received:March 28, 2022 Revised:April 23, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.20.032 |
| 中文关键词: 军事飞行人员 非酒精性脂肪肝病 白细胞计数 C反应蛋白 尿酸 糖脂代谢 胰岛素抵抗 肝纤维化 |
| 英文关键词: Military pilots Nonalcoholic fatty liver disease Leukocyte count C-reactive protein Uric acid Glucose and lipid metabolism Insulin resistance Liver fibrosis |
| 基金项目:山东省医药卫生科技发展计划项目（2016WS595）；军队后勤科研计划面上项目（CKJ17J018） |
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| 中文摘要: |
| 摘要 目的：研究军事飞行人员非酒精性脂肪肝病（NAFLD）患者白细胞计数（WBC）、C反应蛋白（CRP）、尿酸（UA）与糖脂代谢、胰岛素抵抗和肝纤维化指标的相关性。方法：选择2018年7月至2021年12月期间海军青岛特勤疗养中心收治的100例NAFLD军事飞行人员作为NAFLD组，另取同期健康体检者90例作为对照组。检测并对比两组的WBC、CRP、UA、糖脂代谢、胰岛素抵抗以及肝纤维化相关指标，采用Pearson相关系数分析WBC、CRP、UA与糖脂代谢、胰岛素抵抗和肝纤维化指标的相关性。结果：NAFLD组的WBC、CRP、UA水平均明显高于对照组（P<0.05）。NAFLD组的空腹血糖（FBG）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、空腹胰岛素（FINS）、稳态模型胰岛素抵抗指数（HOMA-IR）水平均高于对照组，高密度脂蛋白胆固醇（HDL-C）水平低于对照组（P<0.05）。NAFLD组的Ⅲ型前胶原肽（PC-Ⅲ）、层粘连蛋白（LN）、透明质酸（HA）、Ⅳ型胶原（Col-Ⅳ）水平均明显高于对照组（P<0.05）。Pearson相关性分析结果显示， WBC、CRP、UA与TC、TG、LDL-C、HOMA-IR、PC-Ⅲ、LN、HA、Col-Ⅳ均呈正相关，而与HDL-C呈负相关（P<0.05）； WBC、CRP、UA与FBG、FINS无显著相关性（P>0.05）。结论：军事飞行人员NAFLD患者体内WBC、CRP、UA明显升高，且与糖脂代谢紊乱、胰岛素抵抗和肝纤维化有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between leukocyte count (WBC), C-reactive protein (CRP), uric acid (UA) and glucose and lipid metabolism, insulin resistance and liver fibrosis indexes in military pilots with nonalcoholic fatty liver disease (NAFLD). Methods: 100 cases of military pilots with NAFLD who were admitted to Navy Qingdao Special Service Convalescent Center from July 2018 to December 2021 were selected as the NAFLD group, and 90 healthy people in the same period were selected as the control group. WBC, CRP, UA, glucose and lipid metabolism, insulin resistance and liver fibrosis related indexes were detected and compared between the two groups. Pearson correlation coefficient was used to analyze the correlation between WBC, CRP, UA and glucose and lipid metabolism, insulin resistance and liver fibrosis indexes. Results: The levels of WBC, CRP and UA in NAFLD group were significantly higher than those in control group (P<0.05). The levels of fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting insulin (FINS) and homeostasis model insulin resistance index (HOMA-IR) in NAFLD group were higher than those in the control group, and the level of high density lipoprotein cholesterol (HDL-C) was lower than that in the control group (P<0.05). The levels of type Ⅲ procollagen peptide (PC-Ⅲ), laminin (LN), hyaluronic acid (HA) and type Ⅳ collagen (Col-Ⅳ) in NAFLD group were significantly higher than those in control group (P<0.05). Pearson correlation analysis showed that WBC, CRP and UA were positively correlated with TC, TG, LDL-C, HOMA-IR, PC-Ⅲ, LN, HA and Col-Ⅳ, but negatively correlated with HDL-C (P<0.05). WBC, CRP and UA had no significant correlation with FBG and FINS (P>0.05). Conclusion: WBC, CRP and UA in patients with military pilots with NAFLD increased significantly, which are related to the disorder of glucose and lipid metabolism, insulin resistance and liver fibrosis. |
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