| 谢嘉瑜,米建平,余焯燊,伍华兵,胡正喜.互动式头针联合认知训练对脑卒中后认知功能障碍患者认知功能、事件相关电位P300和血清NSE、S100β蛋白的影响[J].现代生物医学进展英文版,2022,(20):3908-3911. |
| 互动式头针联合认知训练对脑卒中后认知功能障碍患者认知功能、事件相关电位P300和血清NSE、S100β蛋白的影响 |
| Effects of Interactive Scalp Acupuncture Combined with Cognitive Training on Cognitive Function, Event-Related Potential P300 and Serum NSE and S100β Proteins in Patients with Post-Stroke Cognitive Dysfunction |
| Received:March 24, 2022 Revised:April 20, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.20.021 |
| 中文关键词: 互动式头针 认知训练 脑卒中 认知功能障碍 事件相关电位P300 NSE S100β蛋白 |
| 英文关键词: Interactive scalp acupuncture Cognitive training Stroke Cognitive dysfunction Event related potential P300 NSE S100β protein |
| 基金项目:广东省中医药局科研项目（201711223） |
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| 中文摘要: |
| 摘要 目的：观察认知训练联合互动式头针对脑卒中后认知功能障碍患者事件相关电位P300、认知功能和血清神经元特异性烯醇化酶（NSE）、S100β蛋白的影响。方法：选取自2019年3月~2022年1月期间广州中医药大学第二附属医院收治的120例脑卒中后认知功能障碍患者。按抛掷硬币法将患者分为对照组（n=60，常规治疗）和研究组（n=60，常规治疗基础上接受互动式头针训练）。对比两组疗效、认知功能、事件相关电位P300和血清NSE、S100β蛋白的差异。结果：研究组的临床总有效率91.67%（55/60）高于对照组75%（45/60），差异有统计学意义（P<0.05）。研究组治疗后简易智力状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）评分高于对照组（P<0.05）。研究组治疗后血清NSE、S100β蛋白水平低于对照组（P<0.05）。研究组治疗后潜伏期短于对照组，波幅长于对照组（P<0.05）。结论：认知训练联合互动式头针可有效改善脑卒中后认知功能障碍患者的认知功能，且与调节事件相关电位P300和血清NSE、S100β蛋白水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of cognitive training combined with interactive scalp acupuncture on event-related potential P300, cognitive function and serum neuron specific enolase (NSE) and S100β proteins in patients with post-stroke cognitive dysfunction. Methods: 120 patients with post-stroke cognitive dysfunction admitted to the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from March 2019 to January 2022 were selected. The patients were divided into control group (n=60, conventional treatment) and study group (n=60, interactive scalp acupuncture training on the basis of conventional treatment) by coin tossing method. The differences in efficacy, cognitive function, event-related potential P300 and serum NSE and S100β proteins were compared between the two groups. Results: The total effective rate of the study group was 91.67% (55/60) higher than 75% (45/60) of the control group, the difference was statistically significant(P<0.05). The scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA) of the study group after treatment were higher than those of the control group (P<0.05). The levels of serum NSE and S100β protein of the study group after treatment were lower than those of the control group (P<0.05). The incubation period of the study group after treatment was shorter than that of the control group, and the wave amplitude was longer than that of the control group (P<0.05). Conclusion: Cognitive training combined with interactive scalp acupuncture can effectively improve the cognitive function of patients with post-stroke cognitive dysfunction, and it is associated with the regulation of event-related potential P300 and serum NSE and S100β protein levels. |
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