| 陈 静,颜红丽,王 超,张梦霓,李 萍,李 毅,魏艳玲.T3期子宫内膜癌的MRI影像表现及其与ER、PR、C-erbB-2及Ki-67表达的关系研究[J].现代生物医学进展英文版,2022,(19):3785-3789. |
| T3期子宫内膜癌的MRI影像表现及其与ER、PR、C-erbB-2及Ki-67表达的关系研究 |
| MRI Findings of T3 Stage Endometrial Carcinoma and Their Relationship with Expression of ER, PR, C-erbb-2 and Ki-67 |
| Received:April 06, 2022 Revised:April 29, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.19.037 |
| 中文关键词: 子宫内膜癌 磁共振成像 ER PR C-erbB-2 Ki-67 相关性 |
| 英文关键词: Endometrial cancer Magnetic resonance imaging ER PR C-erbB-2 Ki-67 Correlation |
| 基金项目:陕西省卫生健康科研基金项目（2018D036） |
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| 中文摘要: |
| 摘要 目的：探讨T3期子宫内膜癌的磁共振成像（MRI）影像表现及其与雌激素受体（ER）、孕激素受体（PR）、表皮生长因子受体2（C-erbB-2）及增殖细胞核抗原67（Ki-67）表达的相关性。方法：收集2016年1月-2021年10月于我院经手术病理证实为子宫内膜癌的患者194例，分析T3期子宫内膜癌的MRI影像表现，免疫组织化学染色方法检测子宫内膜癌患者ER、PR、C-erbB-2、Ki-67的表达，探讨T分期与ER、PR、C-erbB-2、Ki-67表达的关系及相关性，分析T3期子宫内膜癌MRI征象与ER、PR、C-erbB-2、Ki-67阳性表达的关系。结果：T3期子宫内膜癌MRI主要表现为子宫体积增大，子宫内膜明显不均匀增厚并见增多软组织团块形成，子宫全肌层连续性中断，浆膜面不光滑，可见子宫附件、宫颈、阴道、宫旁组织受累，可见腹主动脉旁、髂动脉旁及盆腔淋巴结转移。随着MRI诊断T分期级别增加，ER、PR阳性率逐渐降低，C-erbB-2、Ki-67阳性率逐渐升高；ER、PR、C-erbB-2、Ki-67阳性率在MRI诊断T分期中差异均有统计学意义（P＜0.05）。ER、PR阳性表达与MRI影像表现T分期呈负相关性（P＜0.05），C-erbB-2、Ki-67阳性表达与MRI影像表现T分期呈正相关性（P＜0.05）。T3期子宫内膜癌MRI征象中有浆膜面受累、子宫附件受累、阴道受累及淋巴结转移或脉管癌栓时，多提示ER和PR阳性表达率降低，C-erbB-2和Ki-67阳性表达率升高，差异有统计学意义（P＜0.05）。结论：MRI检查对子宫内膜癌术前分期具有重要价值，影像表现与肿瘤标记物密切相关，可在一定程度上反映肿瘤细胞的恶性程度、分化程度、侵袭能力，有助于鉴别其病理分级，为临床综合治疗及预后提供依据。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the magnetic resonance imaging (MRI) findings of T3 stage） endometrial carcinoma and its correlation with the expression of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor 2 (C-erbB-2) and proliferating nuclear antigen 67 (Ki-67). Methods: A total of 194 patients with endometrial cancer confirmed by surgical pathology in our hospital from January 2016 to October 2021 were collected.MRI images of T3 stage endometrial cancer were analyzed, and the expressions of ER, PR, C-erbB-2 and Ki-67 were detected by immunohistochemical staining. To investigate the relationship and correlation between T stage and the expression of ER, PR, C-erbB-2 and Ki-67, and to analyze the relationship between MRI signs and the positive expression of ER, PR, C-erbB-2 and Ki-67 in T3 stage endometrial carcinoma. Results: T3 stage MRI mainly for uterine endometrial cancer volume increases, the endometrium obvious uneven thickening and see an increase in the soft tissue mass formed, uterine muscular layer all continuity interrupt, serosal surface was not smooth, uterus, cervical, vaginal, annex visible near the palace group involvement,visible near the abdominal aorta,iliac artery branch into pelvic lymph node metastasis. The positive rate of ER and PR decreased gradually, while the positive rate of C-erbB-2 and Ki-67 increased gradually with the increase of T stage grade of MRI diagnosis. The positive rates of ER, PR, C-erbB-2 and Ki-67 were significantly different in MRI diagnosis of T stage(P<0.05). The positive expression of ER and PR was negatively correlated with the T staging of MRI images (P<0.05), and the positive expression of C-erbB-2 and Ki-67 was positively correlated with the T staging of MRI images(P<0.05). When there were serous surface involvement, uterine adnexa involvement, vaginal involvement, lymph node metastasis or vascular tumor plug in the MRI signs of T3 stage endometrial carcinoma, the positive expression rates of ER and PR were mostly decreased, and the positive expression rates of C-erbB-2 and Ki-67 were increased, with statistical significance(P<0.05). Conclusion: MRI examination is of great value for preoperative staging of endometrial cancer.The imaging manifestations are closely related to tumor markers, which can reflect the malignant degree, differentiation degree and invasion ability of tumor cells to a certain extent, help to differentiate the pathological grades, and provide basis for clinical comprehensive treatment and prognosis. |
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