| 雷 军,陈健国,吴金训,许文静,刘玉明,姚丽清.肝细胞肝癌组织NTS、SPNS2、Mortalin表达与上皮间质转化标志物、临床病理特征和预后的关系[J].现代生物医学进展英文版,2022,(19):3704-3708. |
| 肝细胞肝癌组织NTS、SPNS2、Mortalin表达与上皮间质转化标志物、临床病理特征和预后的关系 |
| Relationship between the NTS, SPNS2 and Mortalin Expression and Epithelial-Mesenchymal Transition Markers, Clinicopathological Features and Prognosis in Hepatocellular Carcinoma |
| Received:March 26, 2022 Revised:April 22, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.19.020 |
| 中文关键词: 肝细胞癌 NTS SPNS2 Mortalin 上皮间质转化 临床病理特征 预后 |
| 英文关键词: Hepatocellular carcinoma NTS SPNS2 Mortalin Epithelial-mesenchymal transition Clinicopathological features Prognosis |
| 基金项目:福建省自然科学基金项目（2016J015841） |
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| 中文摘要: |
| 摘要 目的：探讨肝细胞癌（HCC）癌组织神经降压素（NTS）、鞘氨醇-1-磷酸转运体2（SPNS2）、热休克蛋白75（Mortalin）表达与上皮间质转化（EMT）标志物、临床病理特征和预后的关系。方法：选取2010年1月～2017年1月联勤保障部队第九〇〇医院仓山院区收治的90例HCC患者，采用免疫组化法检测患者癌组织和对应癌旁组织中NTS、SPNS2、Mortalin及EMT标志物N-钙粘蛋白（N-Cad）、E-钙粘蛋白（E-Cad）表达情况。分析NTS、SPNS2、Mortalin表达与HCC患者EMT标志物、临床病理特征和预后的关系。结果：HCC癌组织中NTS、SPNS2、Mortalin、N-Cad阳性表达率高于癌旁组织，E-Cad阳性表达率低于癌旁组织（P＜0.05）。Pearson相关性分析显示，HCC癌组织中NTS、SPNS2、Mortalin表达水平与N-Cad表达水平呈正相关，与E-Cad表达水平呈负相关（P＜0.05）。 HCC癌组织中NTS、SPNS2、Mortalin表达与Child-Pugh分级、血管侵犯、巴塞罗那临床肝癌（BCLC）分期、淋巴结转移、远处转移有关（P＜0.05）。90例HCC患者术后5年总生存率为48.89％（44/90）。Kaplan-Meier生存曲线分析显示，NTS、SPNS2、Mortalin阳性组总生存率分别低于NTS、SPNS2、Mortalin阴性组（P＜0.05）。结论：HCC癌组织中NTS、SPNS2、Mortalin表达上调，与EMT、Child-Pugh分级、血管侵犯、BCLC分期、淋巴结转移、远处转移和预后有关，可作为HCC病情及预后的辅助评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between neurotensin (NTS), sphingosine-1-phosphate transporter 2 (SPNS2) and Mortalin expression and epithelial-mesenchymal transition (EMT) markers, clinicopathological features and prognosis in hepatocellular carcinoma (HCC). Methods: 90 patients with HCC were selected from Cangshan Hospital of the 900 Hospital of Joint Logistics Support Force from January 2010 to January 2017 were selected, The NTS, SPNS2, Mortalin and EMT markers N-cadherin (N-Cad) and E-cadherin (E-Cad) expression in cancer tissues and corresponding paracancerous tissues were detected by immunohistochemistry. The relationship between the NTS, SPNS2 and Mortalin expression and EMT markers, clinicopathological features and prognosis in patients with HCC were analyzed. Results: The positive expression rates of NTS, SPNS2, Mortalin and N-Cad in HCC cancer tissues were higher than those in paracancerous tissues, and the positive expression rate of E-Cad was lower than that in paracancerous tissues (P<0.05). Pearson correlation analysis showed that the NTS, SPNS2 and Mortalin expression levels in HCC cancer tissues were positively correlated with the N-Cad expression level, and negatively correlated with the E-Cad expression level (P<0.05). The NTS, SPNS2 and Mortalin expressions in HCC cancer tissues were related to Child-Pugh grade, vascular invasion, Barcelona clinical liver cancer (BCLC) stage, lymph node metastasis and distant metastasis (P<0.05). The 5-year overall survival rate of 90 patients with HCC was 48.89% (44 / 90). Kaplan-Meier survival curve analysis showed that the overall survival rate of NTS, SPNS2 and Mortalin positive groups was lower than that of NTS, SPNS2 and Mortalin negative groups respectively (P<0.05). Conclusion: The up-regulated of NTS, SPNS2 and Mortalin expression in HCC cancer tissues, which is related to EMT, Child-Pugh grade, vascular invasion, BCLC stage, lymph node metastasis, distant metastasis and prognosis. It can be used as an auxiliary evaluation index for the condition and prognosis of HCC. |
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