| 汪 杰,王小永,李宏增,张 华,任 敏.急性脑梗死患者血清H-FABP、干扰素-γ、半胱氨酸和Ang-1联合检测及其临床意义[J].现代生物医学进展英文版,2022,(17):3329-3332. |
| 急性脑梗死患者血清H-FABP、干扰素-γ、半胱氨酸和Ang-1联合检测及其临床意义 |
| Combined Detection of Serum H-FABP, Interferon-γ, Cysteine and Ang-1 in Patients with Acute Cerebral Infarction and Its Clinical Significance |
| Received:February 24, 2022 Revised:March 21, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.17.025 |
| 中文关键词: 急性脑梗死 H-FABP 干扰素-γ 同型半胱氨酸 血管生成素-1 诊断 |
| 英文关键词: Acute cerebral infarction H-FABP Interferon-γ Homocysteine Angiopoietin-1 Diagnosis |
| 基金项目:陕西省重点研发计划项目（2019SF-009） |
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| 中文摘要: |
| 摘要 目的：探讨急性脑梗死患者血清心型脂肪酸结合蛋白（H-FABP）、干扰素-γ（IFN-γ）、同型半胱氨酸（Hcy）、血管生成素-1（Ang-1）联合检测及其临床意义。方法：选取本院自2018年4月-2021年4月收治的66例急性脑梗死患者的临床资料，将其作为研究组。同时选取同期来院体检的健康者66例为对照组，均通过酶联免疫吸附试验试剂盒检测H-FABP、IFN-γ、Hcy、Ang-1水平，比较各组检测水平，分析联合检测意义。结果：研究组患者的H-FABP、IFN-γ、Hcy水平均高于对照组相应指标，Ang-1水平低于对照组水平，差异均具有统计学意义（P＜0.05）；H-FABP、IFN-γ、Hcy、Ang-1水平在不同病情间差异具有统计学意义（P＜0.05），其中与轻度、中度相比，重度患者的H-FABP、IFN-γ、Hcy水平更高，Ang-1水平更低，差异具有统计学意义（P<0.05）；急性脑梗死患者病情与H-FABP、IFN-γ、Hcy呈正相关，与Ang-1呈负相关，有统计学意义（P<0.05）；急性脑梗死患者H-FABP与IFN-γ、Hcy指标相互间呈现正相关关系，与Ang-1呈现负相关关系（P<0.05）。结论：急性脑梗死患者联合检测H-FABP、IFN-γ、Hcy、Ang-1水平具有重要意义，可作为疾病早期诊断的重要指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the serum heart-shaped fatty acid binding protein (H-FABP), interferon-γ (IFN-γ), homocysteine (Hcy), and angiopoietin-1 (Ang-1) in patients with acute cerebral infarction Combined detection and its clinical significance. Methods: The clinical data of 66 patients with acute cerebral infarction admitted to our hospital from April 2018 to April 2021 were selected as the research group. At the same time, 66 healthy people who came to the hospital for physical examination during the same period were selected as the control group. The levels of H-FABP, IFN-γ, Hcy, and Ang-1 were detected by enzyme-linked immunosorbent assay kits. The detection levels of each group were compared, and the significance of combined detection was analyzed. Results: The levels of H-FABP, IFN-γ, and Hcy in the study group were higher than the corresponding indicators in the control group, and the Ang-1 level was lower than that in the control group; H-FABP, The levels of IFN-γ, Hcy, and Ang-1 are statistically significant in different conditions (P<0.05). Compared with mild and moderate, severe patients have higher levels of H-FABP, IFN-γ, and Hcy. Ang-1 level was lower(P<0.05); the condition of patients with acute cerebral infarction was positively correlated with H-FABP, IFN-γ, and Hcy, and negatively correlated with Ang-1, which was statistically significant (P<0.05); In patients with acute cerebral infarction, H-FABP, IFN-γ, and Hcy are positively correlated with each other, and negatively correlated with Ang-1 (P<0.05). Conclusion: The combined detection of H-FABP, IFN-γ, Hcy and Ang-1 levels in patients with acute cerebral infarction is of great significance and can be used as an important indicator for early diagnosis of the disease. |
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