| 李金娟,许海琦,张玲明,刘晓莉,李永桂,杨历新.血清Ghrelin、p21 waf/cip1以及IGF-1与儿童特发性矮小症相关性分析[J].现代生物医学进展英文版,2022,(15):2990-2994. |
| 血清Ghrelin、p21 waf/cip1以及IGF-1与儿童特发性矮小症相关性分析 |
| Correlation Analysis of Serum Ghrelin, p21 Waf/cip1 and IGF-1 with Idiopathic Short Stature in Children |
| Received:January 11, 2022 Revised:January 31, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.15.037 |
| 中文关键词: 生长激素释放肽 p21 waf/cip1 胰岛素生长因子-1 特发性矮小症 |
| 英文关键词: Ghrelin p21 waf/cip1 Insulin-like growth factor-1 Idiopathic short stature |
| 基金项目:青海省科技计划项目（2020-ZJ-930） |
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| 中文摘要: |
| 摘要 目的：研究特发性矮小症（ISS）儿童血清生长激素释放肽（Ghrelin）、p21 waf/cip1以及胰岛素生长因子-1（IGF-1）水平及其临床意义。方法：选择2017年1月到2020年12月在我院接受治疗的特发性矮小症儿童60例（ISS组），选择同期体检健康儿童60例作为对照（对照组），比较两组儿童一般资料，检测并比较两组儿童血清Ghrelin、p21 waf/cip1以及IGF-1水平。分析ISS儿童血清Ghrelin、p21 waf/cip1以及IGF-1水平与生长指标的相关性，同时分析治疗对其影响。结果：（1）ISS组患儿性别、年龄和体质指数与对照组比较无显著差异（P>0.05），但身高、体重以及生长速度显著低于对照组儿童（P<0.05）；（2）ISS组患儿血清Ghrelin和p21 waf/cip1均显著高于对照组，而血清IGF-1显著低于对照组（P<0.05）；（3）ISS组患儿血清Ghrelin和p21 waf/cip1均与身高、体重和生长速度呈负相关，而血清IGF-1与身高、体重和生长速度呈正相关（P<0.05）；（4）治疗显著提高ISS组患儿身高、体重、生长速度以及血清IGF-1水平，而显著降低ISS组患儿血清Ghrelin和p21 waf/cip1水平（P<0.05）。结论：Ghrelin、p21 waf/cip1和IGF-1在特发性矮小症患儿血清中表达异常，共同调控儿童生长发育，是评价儿童生长发育的良好指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study the serum levels of Ghrelin, P21 WAF/CIP1 and insulin growth factor-1 in children with idiopathic short stature (ISS) and their clinical significance. Methods: A total of 60 children with idiopathic short stature who received treatment in our hospital from January 2017 to December 2020 (ISS group) and 60 healthy children who underwent physical examination during the same period were selected as the control group (control group). General data of the two groups were compared, and serum levels of Ghrelin, P21 WAF/CIP1 and IGF-1 were detected and compared between the two groups. To analyze the correlation between serum levels of Ghrelin, P21 WAF/CIP1 and IGF-1 and growth indexes in ISS children, and to analyze the effect of treatment on them. Results: (1) The gender, age and body mass index of children in the ISS group were not different from those in the control group(P>0.05), but their height, weight and growth rate were lower than those in the control group(P<0.05); (2) ISS group Serum Ghrelin and p21 waf/cip1 in children were higher than those in the control group, while serum IGF-1 was lower than in the control group (P<0.05); (3) Serum Ghrelin and p21 waf/cip1 in children in the ISS group cip1 was negatively correlated with height, weight, and growth rate, while serum IGF-1 was positively correlated with height, weight, and growth rate (P<0.05); (4) Treatment increased the height, weight, and growth rate of children in the ISS group. Body weight, growth rate, and serum IGF-1 level, and reduced serum Ghrelin and p21 waf/cip1 levels in ISS group (P<0.05). Conclusion: Ghrelin, p21 waf/cip1 and IGF-1 are abnormally expressed in the serum of children with idiopathic short stature, and they jointly regulate the growth and development of children. They are good indicators for evaluating the growth and development of children. |
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