| 林 媛,笪茂红,乔 伟,高 晴,许 伟.超声检查参数联合血清VEGF、Tg、Gal-1对甲状腺癌的诊断价值及其与淋巴结转移的关系[J].现代生物医学进展英文版,2022,(15):2976-2980. |
| 超声检查参数联合血清VEGF、Tg、Gal-1对甲状腺癌的诊断价值及其与淋巴结转移的关系 |
| Diagnostic Value of Ultrasonographic Examination Parameters Combined with Serum VEGF, Tg and Gal-1 in Thyroid Cancer and its Relationship with Lymph Node Metastasis |
| Received:February 05, 2022 Revised:February 28, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.15.034 |
| 中文关键词: 甲状腺癌 超声检查 血管内皮生长因子 甲状腺球蛋白 半乳糖血凝素-1 诊断价值 淋巴结转移 相关性 |
| 英文关键词: Thyroid cancer Ultrasonography examination VEGF Tg Gal-1 Diagnostic value Lymph node metastasis Correlation |
| 基金项目:江苏省自然科学基金优秀青年项目（BK201600542） |
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| 中文摘要: |
| 摘要 目的：探讨超声检查参数联合血清血管内皮生长因子（VEGF）、甲状腺球蛋白（Tg）、半乳糖血凝素-1（Gal-1）对于甲状腺癌的临床诊断价值及其与淋巴结转移的关系。方法：回顾性分析2017年6月至2020年6月入我院就诊的158例甲状腺肿瘤患者的临床资料。77例甲状腺癌患者纳入恶性组，81例甲状腺腺瘤患者纳入良性组，比较两组的超声检查参数及血清VEGF、Tg、Gal-1水平；此外，恶性组患者亚分组为淋巴结转移组（n=51）和无淋巴结转移组（n=26），比较两组超声检查参数及血清VEGF、Tg、Gal-1水平。以受试者工作特征（ROC）曲线分析超声检查参数联合血清VEGF、Tg、Gal-1对甲状腺癌的诊断效能。采用Sprearman相关系数分析各指标水平变化与甲状腺癌患者发生淋巴结转移的相关性。结果：恶性组患者的血管化指数（VI）、血流指数（FI）及血清VEGF、Tg、Gal-1水平均高于良性组患者（P＜0.05）；淋巴转移组患者的VI、FI及血清VEGF、Tg、Gal-1水平均高于无淋巴结转移组患者（P＜0.05）；超声检查参数VI、FI联合血清VEGF、Tg、Gal-1诊断甲状腺癌的曲线下面积为0.933、敏感度为85.50%、特异度为80.00%，均明显高于五项指标单独检测。Spearman相关性分析结果显示，超声检查参数VI、FI以及血清VEGF、Tg、Gal-1与甲状腺癌患者淋巴结转移均呈正相关（P＜0.05）。结论：联合检测超声检查参数VI、FI及血清VEGF、Tg、Gal-1对甲状腺癌有较高的早期诊断价值，且上述指标均与患者淋巴结转移密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical diagnostic value of ultrasonography examination parameters combined with serum vascular endothelial growth factor(VEGF), thyroglobulin (Tg) and galectin-1 (Gal-1) in thyroid cancer and its relationship with lymph node metastasis. Methods: The clinical data of 158 patients with thyroid tumor who were admitted to our hospital from June 2017 to June 2020 were retrospectively analyzed. 77 patients with thyroid cancer were included in the malignant group, and 81 patients with thyroid adenoma were included in the benign group. Ultrasonography examination parameters and serum VEGF, Tg and Gal-1 levels were compared between the two groups. In addition, patients in the malignant group were subdivided into lymph node metastasis group (n=51) and non lymph node metastasis group(n=26). Ultrasonography examination parameters and serum VEGF, Tg and Gal-1 levels were compared between the two groups. Receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficacy of ultrasonography examination parameters combined with serum VEGF, Tg and Gal-1 in thyroid cancer. Sprearman correlation coefficient was used to analyze the correlation between the changes of each index level and lymph node metastasis in patients with thyroid cancer. Results: The vascularity index (VI), flow index (FI) and serum VEGF, Tg and Gal-1 levels in patients with malignant group were higher than those in patients with benign group (P＜0.05). The VI, FI and serum VEGF, Tg and Gal-1 levels in patients with lymph node metastasis group were higher than those in patients with non lymph node metastasis group (P＜0.05). Ultrasonography examination parameters VI and FI combined with serum VEGF, Tg and GAL-1 in the diagnosis of thyroid cancer showed an area under the curve was 0.933, the sensitivity was 85.50%, and the specificity was 80.00%, which were significantly higher than the five indexes detected alone. Spearman correlation analysis showed that ultrasonography examination parameters VI and FI as well as serum VEGF, Tg and Gal-1 were positively correlated with lymph node metastasis in thyroid cancer patients (P<0.05). Conclusion: Combined detection of ultrasonography examination parameters VI, FI and serum VEGF, Tg and Gal-1 has high early diagnostic value for thyroid cancer, and the above indexes are closely related to lymph node metastasis. |
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