| 张 振,徐 帅,白雪峰,云宇婷,卢德芳.重症胰腺炎早期液体复苏及蛋白血浆制品干预的疗效分析[J].现代生物医学进展英文版,2022,(15):2918-2921. |
| 重症胰腺炎早期液体复苏及蛋白血浆制品干预的疗效分析 |
| Analysis of the Curative Effect of Early Liquid Resuscitation and Protein Plasma Products Intervention in Severe Pancreatitis |
| Received:November 23, 2021 Revised:December 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.15.023 |
| 中文关键词: 液体复苏 蛋白血浆制品 重症胰腺炎 |
| 英文关键词: Fluid resuscitation Protein plasma products Severe pancreatitis |
| 基金项目:内蒙古自治区科技计划项目（201602097） |
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| 中文摘要: |
| 摘要 目的：探究与分析重症胰腺炎早期液体复苏及蛋白血浆制品干预的疗效。方法：2018年7月到2021年4月选择在本院诊治的重症胰腺炎患者94例，根据随机数字1：1分组法将患者分为研究组与对照组各47例。对照组给予常规早期液体复苏治疗，研究组在对照组治疗的基础上给予蛋白血浆制品治疗，所有患者都治疗观察5 d。对比与记录两组患者的预后变化情况。结果：研究组治疗期间并发症及机械通气发生率低于对照组（P<0.05）；两组治疗的血乳酸值低于治疗前，乳酸清除率高于治疗前（P<0.05）；两组治疗后的SOFA评分和APACHE Ⅱ评分低于治疗前，研究组低于对照组（P<0.05）；两组治疗后的的血小板与血红蛋白水平都低于治疗前，研究组高于对照组（P<0.05）。结论：早期液体复苏联合蛋白血浆制品干预在重症胰腺炎的应用能改善患者的病情与血乳酸状况，有利于血小板与血红蛋白水平恢复正常，从而能降低患者的并发症与机械通气发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To explore and analysis the efficacy of early fluid resuscitation and intervention of protein plasma products in severe pancreatitis. Methods: From July 2018 to April 2021, 94 cases of patients with severe pancreatitis were selected to be diagnosed and treated in this hospital. All the cases were divided into the study group and control group with 47 cases each groups accorded to the random number 1:1 grouping method. The control group were given conventional early fluid resuscitation treatment, and the study group were given protein plasma product treatment on the basis of the treatment of the control group. All patients were treated and observed for 5 days. Compared and recorded the changes in the prognosis of the two groups of patients. Results: The incidence of complications and mechanical ventilation in study group was different with control group(P<0.05); The blood lactate value of the two treatment groups after treament were lower than before treatment, and the lactate clearance rate were higher than before treatment, the difference between the study group and the control group were also significance(P<0.05); The SOFA score and APACHE Ⅱ score after treatment in the two groups were lower than before treatment, and the study group were lower than the control group(P<0.05); The levels of platelets and hemoglobin after treatment in the group were lower than before treatment, and the levels of the study group were different with control group(P<0.05). Conclusion: The application of early fluid resuscitation combined with protein plasma product intervention in severe pancreatitis can improve the patient's condition and blood lactic acid status, help the platelet and hemoglobin levels to return to normal, thereby reducing the incidence of complications and mechanical ventilation in patients. |
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