| 李家云,方朝晖,赵进东,陆瑞敏,杨 迪.丹蛭降糖胶囊联合硫辛酸、依帕司他对气阴两虚夹瘀型糖尿病周围神经病变患者血糖水平和下肢神经功能的影响[J].现代生物医学进展英文版,2022,(15):2898-2902. |
| 丹蛭降糖胶囊联合硫辛酸、依帕司他对气阴两虚夹瘀型糖尿病周围神经病变患者血糖水平和下肢神经功能的影响 |
| Effect of Danzhi Jiangtang Capsule Combined with Lipoic Acid and Epalrestat on its Blood Glucose Level and Lower Limb Nerve Function in Diabetes Peripheral Neuropathy Patients with Vital Energy and Yin Combined with Blood Stasis |
| Received:February 06, 2022 Revised:February 28, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.15.019 |
| 中文关键词: 糖尿病周围神经病变 丹蛭降糖胶囊 硫辛酸 依帕司他 气阴两虚夹瘀型 血糖水平 下肢神经功能 |
| 英文关键词: Diabetic peripheral neuropathy Danzhi Jiangtang capsule Lipoic acid Epalrestat Vital Energy and Yin Combined with Blood Stasis Blood glucose level Lower limb nerve function |
| 基金项目:国家自然科学基金项目（81774286） |
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| 中文摘要: |
| 摘要 目的：探讨丹蛭降糖胶囊联合硫辛酸、依帕司他治疗气阴两虚夹瘀型糖尿病周围神经病变（DPN）的临床疗效，并分析其对血糖和下肢神经功能的影响。方法：按照随机数字表法将81例DPN患者分成对照组40例和观察组41例，对照组在2型糖尿病治疗基础上使用硫辛酸静滴联合依帕司他口服治疗，观察组在对照组治疗基础上，加用丹蛭降糖胶囊口服治疗。比较两组治疗前后中医证候积分、双下肢肌电图[腓总神经运动神经传导速度（MCV）、腓肠神经感觉神经传导速度（SCV）]、电流感觉阈值（CPT值）、血糖指标[空腹血糖（FPG）、餐后2小时血糖（2 hBG）、糖化血红蛋白（HbA1c）]水平变化，并对比两组总有效率和治疗方案安全性。结果：观察组总有效率为90.24%（37/41），明显高于对照组的70.00%（28/40），差异有统计学意义（P＜0.05）；治疗8周后，两组肢体麻木、肢体末梢疼痛、神疲乏力、气短懒言、腰膝酸软、失眠烦躁积分，FPG、2 hBG、HbA1c水平均明显降低（P＜0.05），且观察组各项中医证候积分和血糖指标水平均明显低于对照组（P＜0.05）；治疗8周后，观察组相同频率正弦交流电刺激下的第一脚趾远端趾节甲小皮基部近端的CPT值均明显低于对照组（P＜0.05），腓总神经MCV、腓肠神经SCV均明显高于对照组（P＜0.05）；两组治疗过程中均未发生明显药物不良反应。结论：丹蛭降糖胶囊口服联合硫辛酸、依帕司他治疗气阴两虚夹瘀型DPN，能够有效缓解患者的临床症状和体征，控制血糖水平，改善下肢神经功能，疗效明显优于单纯西药治疗，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Danzhi Jiangtang capsule combined with lipoic acid and epalrestat in the treatment of diabetic peripheral neuropathy with Vital Energy and Yin Combined with Blood Stasis, and to analyze its effects on blood glucose and nerve function of lower limbs. Methods: According to random number table method, the 81 cases of diabetic peripheral neuropathy patients were divided into control group (40 cases) and observation group (41 cases), and the control group was treated with lipoic acid drip combined with epalrestat orally on the basis of type 2 diabetes, the observation group was treated with Danzhi hypoglycemic capsule orally on the basis of the control group. The TCM syndrome scores , electromyography of both lower limbs [common peroneal nerve motor nerve conduction velocity (MCV), sural nerve sensory nerve conduction velocity (SCV)], current perception threshold (CPT value), blood glucose indicators [fasting plasma glucose (FPG), 2-hour postprandial blood glucose(2 hBG), glycosylated hemoglobin (HbA1c)] changes before and after treatment between the two groups were observed and compared, the total effective rate and the safety of treatment were compared between the two groups. Results: The total effective rate in the observation group was 90.24% (37/41), which was significantly higher than 70.00% (28/40) in the control group, and the difference was statistically significant (P<0.05). 8 weeks after treatment, the scores of limb numbness, limb tip pain, mental fatigue, shortness of breath and lazy speech, weakness of waist and knee, insomnia and irritability, FPG, 2 hBG, HbA1c levels were significantly decreased in both groups (P<0.05), and the TCM syndrome scores and blood glucose levels in the observation group were significantly lower than those in the control group(P<0.05). 8 weeks after treatment, the CPT value of the proximal base of the first distal toe cortex in the observation group under the same frequency sinusoidal AC stimulation was significantly lower than that in the control group(P<0.05), and the common peroneal nerve MCV and sural nerve SCV in the observation group were significantly higher than those in the control group(P<0.05). There were no obvious adverse drug reactions in the two groups. Conclusion: Danzhi Jiangtang capsule oral combined with lipoic acid and epalrestat in the treatment of diabetic peripheral neuropathy with Vital Energy and Yin Combined with Blood Stasis can effectively relieve the clinical symptoms and signs of patients, control blood glucose level, improve the nerve function of lower limbs, the efficacy is significantly better than the treatment of western medicine alone, and the safety is high. |
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