| 哈丽娜·哈力克,李 婷,代梦莹,于 琳,高 峰.血清MUC1、SCD-1、NLRP3在溃疡性结肠炎患者中的表达与凝血功能异常的相关性[J].现代生物医学进展英文版,2022,(14):2743-2747. |
| 血清MUC1、SCD-1、NLRP3在溃疡性结肠炎患者中的表达与凝血功能异常的相关性 |
| Correlation between the Expression of Serum MUC1, SCD-1 and NLRP3 in Patients with Ulcerative Colitis and Abnormal Coagulation Function |
| Received:January 24, 2022 Revised:February 21, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.14.029 |
| 中文关键词: 溃疡性结肠炎 硬脂酰辅酶A脱氢酶-1 NLRP3炎症小体 粘蛋白1 |
| 英文关键词: Ulcerative colitis Stearoyl-CoA dehydrogenase-1 NLRP3 inflammasome Mucin 1 |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2021D01C200） |
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| 中文摘要: |
| 摘要 目的：探讨与分析血清粘蛋白1（MUC1）、硬脂酰辅酶A脱氢酶-1（SCD-1）、含NLR家族PYRIN域蛋白3（NLRP3）在溃疡性结肠炎患者中的表达与凝血功能异常的相关性。方法：2019年8月到2021年7月选择在本院诊治的溃疡性结肠炎患者78例作为病例组（包括轻度组患者50例与中重度组患者28例），同期选择在本院进行体检的健康人员78例作为对照组，检测三组血清MUC1、SCD-1、NLRP3水平与凝血指标，同时进行相关性分析与影响因素分析。结果：三组的血小板计数（PLT）、平均血小板体积（MPV）、血红蛋白（HGB）对比无差异（P>0.05）。中重度组与轻度组的血清MUC1、SCD-1、NLRP3含量高于对照组，中重度组高于轻度组（P<0.05）。中重度组与轻度组的部分凝血活酶时间（APTT）、凝血酶原时间（PT）低于对照组，纤维蛋白原（FIB）高于对照组，中重度组与轻度组对比也存在差异（P<0.05）。在病例组中，Pearson 分析显示血清MUC1、SCD-1、NLRP3表达水平与凝血指标存在相关性（P<0.05）。Logistic多元回归方程显示MUC1、SCD-1、NLRP3等都为影响患者病情活动度的重要因素（P<0.05）。结论：溃疡性结肠炎患者多伴随有血清MUC1、SCD-1、NLRP3的高表达，也多伴随有凝血功能异常，MUC1、SCD-1、NLRP3表达与凝血功能异常存在相关性，也是影响患者病情活动度的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and analysis the serum mucin 1 (MUC1), stearoyl-CoA desaturase-1 (SCD-1), NLR family PYRIN domain protein 3 (NLRP3) in patients with ulcerative colitis with abnormal coagulation function. Methods: From August 2019 to July 2021, 78 cases of patients with ulcerative colitis diagnosed and treated in our hospital were selected as the case group (included 50 patients in the mild group and 28 patients in the moderate-severe group), and the other 78 cases of healthy people who underwent physical examination were used as the control group. The serum levels of MUC1, SCD-1, NLRP3 and coagulation indexes were detected in the three groups, and correlation analysis and influencing factor analysis were carried out at the same time. Results: There wwere no significant difference in platelet count (PLT), mean platelet volume (MPV), and hemoglobin (HGB) compared among the three groups (P>0.05). The serum levels of MUC1, SCD-1 and NLRP3 in the moderate-severe group and the mild group were higher than those in the control group, and the moderate-severe group were higher than the mild group (P<0.05). The partial thromboplastin time (APTT) and prothrombin time (PT) in the moderate-severe group and the mild group were lower than those in the control group, and fibrinogen (FIB) were higher than that in the control group (P<0.05), the difference between moderate- severe group and mild group were also statistically significant (P<0.05). In the case group, Pearson analysis showed that serum MUC1, SCD-1, NLRP3 expression levels were correlated with coagulation indexes (P<0.05); Logistic multiple regression equation showed that MUC1, SCD-1, NLRP3, etc were important factors affected the patient's disease activity(P<0.05). Conclusion: Ulcerative colitis patients are often accompanied by high expression of serum MUC1, SCD-1, NLRP3, and are often accompanied by abnormal coagulation function. The expressions of MUC1, SCD-1 and NLRP3 are correlated with abnormal coagulation function, and are also important factors affecting the disease activity of patients. |
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