| 王 琛,郭姗姗,宋云龙,向生青,卜 石.心脉通胶囊联合非诺贝特对饮食控制疗法效果不佳的高脂血症患者血脂、血液流变学和血管内皮功能的影响[J].现代生物医学进展英文版,2022,(14):2695-2699. |
| 心脉通胶囊联合非诺贝特对饮食控制疗法效果不佳的高脂血症患者血脂、血液流变学和血管内皮功能的影响 |
| Effects of Xinmaitong Capsule Combined with Fenofibrate on Blood Lipid, Hemorheology and Vascular Endothelial Function in Hyperlipidemia Patients with Poor Effect of Diet Control Therapy |
| Received:December 27, 2021 Revised:January 23, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.14.019 |
| 中文关键词: 心脉通胶囊 非诺贝特 饮食控制疗法 高脂血症 血脂 血液流变学 血管内皮功能 |
| 英文关键词: Xinmaitong capsule Fenofibrate Diet control therapy Hyperlipidemia Blood lipid Hemorheology Vascular endothelial function |
| 基金项目:北京市自然科学基金项目（71621751） |
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| 中文摘要: |
| 摘要 目的：观察心脉通胶囊联合非诺贝特对饮食控制疗法效果不佳的高脂血症患者血脂、血液流变学和血管内皮功能的影响。方法：所选病例为我院2019年5月~2021年9月期间接诊的68例饮食控制疗法效果不佳的高脂血症患者。采用随机数字表法进行分组，68例患者共分为对照组和联合组，例数各为34例。对照组患者接受非诺贝特治疗，联合组患者接受心脉通胶囊联合非诺贝特治疗，对比两组临床总有效率、血脂、血液流变学和血管内皮功能，记录两组治疗期间不良反应发生情况。结果：联合组的临床总有效率高于对照组（P<0.05）。治疗2个月后，联合组的血清全血还原黏度、低密度脂蛋白胆固醇（LDL-C）、血管内皮素-1（ET-1）、血浆比黏度、甘油三酯（TG）、全血比黏度、总胆固醇（TC）、纤维蛋白原水平、血细胞比容水平低于对照组，降钙素基因相关肽（CGRP）、高密度脂蛋白胆固醇（HDL-C）、一氧化氮（NO）水平高于对照组（P<0.05）。两组不良反应发生率对比无统计学差异（P>0.05）。结论：心脉通胶囊联合非诺贝特治疗饮食控制疗法效果不佳的高脂血症患者，可有效控制血脂，调节血液流变学和血管内皮功能，应用价值较好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of Xinmaitong capsule combined with fenofibrate on blood lipid, hemorheology and vascular endothelial function in hyperlipidemia patients with poor effect of diet control therapy. Methods: The selected cases were 68 hyperlipidemia patients with poor effect of diet control therapy who were treated in our hospital from May 2019 to September 2021 Random number table method was used for grouping, the 68 patients were divided into control group and combined group, with 34 cases in each group. The patients in the control group were treated with fenofibrate, and the patients in the combined group were treated with Xinmaitong capsule combined with fenofibrate. The total clinical effective rate, blood lipid, hemorheology and vascular endothelial function of the two groups were compared, and the adverse reactions of the two groups during treatment were recorded. Results: The total clinical effective rate of the combined group was higher than that of the control group (P<0.05). 2 months after treatment, serum whole blood reducing viscosity, low density lipoprotein cholesterol (LDL-C), vascular endothelin-1 (ET-1), plasma specific viscosity, triglyceride (TG), whole blood specific viscosity, total cholesterol (TC), fibrinogen level and hematocrit level of combined group were lower than those of control group. The calcitonin gene-related peptide (CGRP), high density lipoprotein cholesterol (HDL-C) and nitric oxide (NO) levels were higher than those of control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Xinmaitong capsule combined with fenofibrate in the treatment of hyperlipidemia patients with poor effect of diet control therapy can effectively control blood lipid, regulate hemorheology and vascular endothelial function, and wihch has good application value. |
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