| 蒋 晨,丁 琳,万新娟,王绍飞,宋 艳.视网膜病变早产儿视网膜厚度与血清血管新生细胞因子PEDF和VEGF表达的相关性[J].现代生物医学进展英文版,2022,(14):2682-2685. |
| 视网膜病变早产儿视网膜厚度与血清血管新生细胞因子PEDF和VEGF表达的相关性 |
| Correlation between Retinal Thickness and the Expression of Serum Angiogenesis Cytokines PEDF and VEGF in Premature Infants with Retinopathy |
| Received:January 24, 2022 Revised:February 21, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.14.016 |
| 中文关键词: 早产儿 视网膜厚度 色素上皮衍生因子 血管内皮生长因子 相关性 影响因素 |
| 英文关键词: Premature infant Retinal thickness PEDF VEGF Correlation Influencing factors |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2021D01C150） |
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| 中文摘要: |
| 摘要 目的：探讨视网膜病变早产儿视网膜厚度与血清血管内皮生长因子（vascular endothelial growth factor，VEGF）、色素上皮衍生因子（pigment epithelium derived factor，PEDF）表达的相关性。方法：采用回顾性研究方法，2016年2月到2021年6月选择在新疆维吾尔自治区人民医院眼科就诊的早产儿视网膜病变患儿80例作为观察组，同期选择足月视网膜病变患儿80例作为对照组，测定两组患儿视网膜厚度，检测血管新生细胞因子-PEDF与VEGF表达情况，对两者进行相关性分析。结果：观察组患儿的颞侧、上方、下方的视网膜神经纤维层厚度都显著高于对照组，两组对比差异明显(P<0.05)。观察组患儿的血清VEGF水平高于对照组，PEDF水平低于对照组，对比差异有统计学意义(P<0.05)。在观察组患儿中，Pearson相关系数相关性分析显示血清PEDF水平与VEGF水平呈现显著负相关性(r=-0.341, P<0.05)；患儿颞侧、上方、下方的视网膜神经纤维层厚度与血清PEDF水平成显著负相关性(P<0.05)，与血清VEGF水平成显著正相关性(P<0.05)。多元logistic回归分析显示血清PEDF、VEGF水平都为导致早产儿视网膜厚度发生的重要因素(P<0.05)。结论：早产儿视网膜厚度均高于足月儿，血管新生细胞因子PEDF、VEGF呈现异常表达情况，视网膜厚度与PEDF、VEGF的表达都有一定的相关性，PEDF、VEGF也为导致早产儿视网膜病变发生的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between retinal thickness and the expression of serum PEDF and VEGF in premature infants with retinopathy. Methods: Retrospective research methods were used and summary study method, From February 2016 to June 2021, 80 cases of children with retinopathy of prematurity in Xinjiang Uygur Autonomous Region People's Hospital were selected as observation group, and 80 cases of children with term retinopathy were selected as the control group at the same time. The retinal thickness of the two groups were measured, and the expression of angiogenic cytokines-PEDF and VEGF were detected, and the correlation analysis were performed. Results: The thickness of retinal nerve fiber layer in theabove, below, and temporal side in the observation group were significantly higher than that of the control group, and compared the difference were statistically significant (P<0.05). The serum VEGF level in the observation group were higher than that of the control group, and the PEDF level were lower than that of the control group, compared the difference were statistically significant (P<0.05). In the observation group, Pearson correlation coefficient correlation analysis showed a significant negative correlation between serum PEDF level and VEGF level (r=-0.341, P<0.05); retinal nerve fiber layer thickness in the above, below, and temporal side in the observation group were significant negative correlation with serum PEDF levels (P<0.05) and were significant positive correlation with serum VEGF levels (P<0.05). Multivariate logistic regression analysis showed that serum PEDF and VEGF levels were important factors leading to retinal thickness in premature infants (P<0.05). Conclusion: The retinal thickness of premature infants is higher than that of term infants, an the angiogenic cytokines PEDF and VEGF are abnormally expressed. The thickness of retina are related to the expression of PEDF and VEGF. PEDF and VEGF are also important factors leading to retinopathy of prematurity. |
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