| 裴戌锋,严友纪,黄 芳,简 宇,将 磊,代凌云.血清ESM-1、VE-Cad、CC16水平与脓毒症并发急性呼吸窘迫综合征患者炎性因子及预后的关系研究[J].现代生物医学进展英文版,2022,(13):2570-2574. |
| 血清ESM-1、VE-Cad、CC16水平与脓毒症并发急性呼吸窘迫综合征患者炎性因子及预后的关系研究 |
| Relationship Study between Serum ESM-1,VE-Cad, CC16 Levels and Inflammatory Factors and Prognosis in Patients with Sepsis Complicated with Acute Respiratory Distress Syndrome |
| Received:January 28, 2022 Revised:February 23, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.13.033 |
| 中文关键词: 脓毒症 急性呼吸窘迫综合征 ESM-1 VE-Cad CC16 炎性因子 预后 |
| 英文关键词: Sepsis Acute respiratory distress syndrome ESM-1 VE-Cad CC166 Inflammatory Factors Prognosis |
| 基金项目:湖北省卫生健康委科研基金项目（WJ2021M080） |
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| 中文摘要: |
| 摘要 目的：探讨血清内皮细胞特异性分子-1（ESM-1）、血管内皮钙黏蛋白（VE-Cad）、Clara细胞分泌蛋白16（CC16）水平与脓毒症并发急性呼吸窘迫综合征（ARDS）患者炎性因子及预后的关系。方法：选取我院2018年10月～2020年1月收治的59例脓毒症并发ARDS患者为研究对象，记作观察组。另取同期于我院进行体检的60例健康志愿者作为对照组。比较两组血清ESM-1、VE-Cad、CC16及炎症因子水平，并以Pearson相关性分析血清ESM-1、VE-Cad、CC16与炎症因子的相关性。此外，将观察组患者按照预后分作死亡组27例和存活组32例，通过多因素Logistic回归分析脓毒症并发ARDS患者预后的影响因素。结果：观察组的血清ESM-1、VE-Cad、CC16水平均高于对照组（P＜0.05）。观察组的IL-6、CRP、PCT水平均高于对照组（P＜0.05）。Pearson相关性分析结果显示：脓毒症并发ARDS患者的血清ESM-1、VE-Cad、CC16水平与IL-6、CRP、PCT水平均呈正相关（P＜0.05）。多因素Logistic回归分析结果显示：年龄（较大）、入院24 h内APACHEⅡ评分（较高）以及血清ESM-1（升高）、VE-Cad（升高）、CC16（升高）、IL-6（升高）、CRP（升高）、PCT（升高）均是脓毒症并发ARDS患者死亡的危险因素，而氧合指数（升高）是患者死亡的保护因素（均P＜0.05）。结论：脓毒症并发ARDS患者血清ESM-1、VE-Cad、CC16水平存在明显升高，且与炎性因子以及预后密切相关，可作为脓毒症并发ARDS患者预后的辅助评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum endothelial-specific molecule-1 (ESM-1), vascular endothelial cadherin (VE-Cad), Clara cell-secreted protein 16 (CC16) levels and inflammatory factors and prognosis in patients with sepsis complicated with acute respiratory distress syndrome (ARDS). Methods: A total of 59 patients with sepsis complicated with ARDS who were diagnosed and treated in our hospital from October 2018 to January 2020 were selected as the research object, and recorded as the observation group. In addition, 60 healthy volunteers who underwent physical examination in our hospital during the same period were selected as control group. The serum ESM-1, VE-Cad, CC16 and inflammatory factors, oxygenation index levels were compared between the two groups, and the correlation between serum ESM-1, VE-Cad, CC16 and inflammatory factors and oxygenation index were analyzed by Pearson correlation. In addition, the observation group was divided into the death group with 27 cases and the survival group with 32 cases according to the prognosis, and multivariate Logistic regression was used to analyze the factors affecting the prognosis of sepsis patients with ARDS. Results: The levels of serum ESM-1, VE-Cad, CC16 in the observation group were higher than those in the control group (P＜0.05). The levels of IL-6, CRP and PCT in the observation group were higher than those in the control group (P＜0.05). Pearson correlation analysis showed that serum ESM-1, VE-Cad and CC16 were positively correlated with IL-6, CRP and PCT in patients with sepsis complicated with ARDS(P＜0.05). Multivariate Logistic regression analysis showed that age (older), APACHE Ⅱ score within 24 hours after admission (higher), serum ESM-1 (elevated), VE-Cad (elevated), CC16 (elevated), IL-6 (elevated), CRP (elevated) and PCT (elevated) were all risk factors for death of sepsis patients with ARDS, while oxygenation index (elevated) was a protective factor for death of patients (all P＜0.05). Conclusion: Serum ESM-1, VE-Cad and CC16 levels are significantly increased in patients with sepsis complicated with ARDS, which are closely related to inflammatory factors and prognosis, and which can be used as prognostic indicators for patients with sepsis complicated with ARDS. |
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