| 王 琦,林 珍,陈海荣,潘碧云,侯晓晓.MTHFR C677T、A1298C基因多态性与老年单纯收缩期高血压患者Hcy、血脂水平的关系研究[J].现代生物医学进展英文版,2022,(10):1951-1955. |
| MTHFR C677T、A1298C基因多态性与老年单纯收缩期高血压患者Hcy、血脂水平的关系研究 |
| Relationship Research between MTHFR C677T, A1298C Gene Polymorphisms and Hcy and Blood Lipid Levels in Elderly Patients with Simple Systolic Hypertension |
| Received:October 22, 2021 Revised:November 17, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.10.032 |
| 中文关键词: 5，10-亚甲基四氢叶酸还原酶 同型半胱氨酸 老年 单纯收缩期高血压 基因多态性 |
| 英文关键词: Methylenetetrahydrofolate reductase Homocysteine Elderly Simple systolic hypertension Gene polymorphisms |
| 基金项目:海南省卫生计生行业科研项目（19A200118） |
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| 中文摘要: |
| 摘要 目的：研究5，10-亚甲基四氢叶酸还原酶（MTHFR）C677T、A1298C基因多态性与老年单纯收缩期高血压（ISH）患者同型半胱氨酸（Hcy）、血脂水平的关系。方法：选取2019年3月至2021年3月期间中南大学湘雅医学院附属海口医院全科医学科收治的212例老年ISH患者作为ISH组，以同期体检无高血压老年人120例为对照组。检测两组MTHFR C677T、A1298C基因多态性。收集两组一般资料及血浆Hcy及血脂检查结果。观察MTHFR C677T、A1298C不同基因型的血浆Hcy、血脂水平差异。采用多因素Logistic回归分析老年ISH发生的影响因素。结果：相比于对照组，ISH组MTHFR C677T位点T等位基因频率较高，C等位基因频率较低；ISH组CC基因型频率较低，CT、TT基因型频率较高（P<0.05）。相比于对照组，ISH组A1298C位点C等位基因频率较高，A等位基因频率较低；ISH组A1298C位点AA基因型频率较低，CC、AC基因型频率较高（P<0.05）。MTHFR基因C677T位点不同基因型血浆Hcy、总胆固醇（TC）水平差异具有显著性（P<0.05）。MTHFR基因A1298C位点不同基因型血浆Hcy、TC水平明显差异具有显著性（P<0.05）。血浆Hcy、MTHFR C677T及A1298C基因多态性是老年ISH发生的影响因素（均P<0.05）。结论：MTHFR C677T、A1298C基因多态性与老年ISH患者血浆TC、Hcy水平有关，血浆Hcy、MTHFR C677T及A1298C基因多态性是老年ISH发生的影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms and the homocysteine (Hcy) and blood lipid levels in elderly patients with simple systolic hypertension (ISH). Methods: 212 elderly patients with ISH who were treated in our hospital from March 2019 to March 2021 were selected as ISH group, and 120 elderly people without hypertension were selected as control group. The MTHFR C677T and A1298C gene polymorphisms in the two groups were detected. The general data, plasma Hcy and blood lipid examination results in the two groups were collected. The difference of plasma Hcy and blood lipid levels of MTHFR C677T and A1298C of different genotypes were observed. Multiple Logistic regression was used to analyze the influencing factors of occurrence of ISH in the elderly. Results: Compared with the control group, the T allelic gene frequency of MTHFR C677T locus in ISH group was higher, and the C allelic gene frequency was lower. The CC genotype frequency in ISH group was lower, and the CT and TT genotype frequencies were higher (P<0.05). Compared with the control group, the C allelic gene frequency of A1298C locus in ISH group was higher, and the A allelic gene frequency was lower. The AA genotype frequency at A1298C locus in ISH group was lower, and the CC and AC genotype frequencies were higher (P<0.05). There were significant differences in plasma Hcy and total cholesterol (TC) levels among different at MTHFR gene C677T locus genotypes (P<0.05). There were significant differences in plasma Hcy and TC levels among different genotypes at MTHFR gene A1298C locus (P<0.05). Plasma Hcy, MTHFR C677T and A1298C gene polymorphisms were the influencing factors of occurrence of ISH in the elderly (all P<0.05). Conclusion: MTHFR C677T and A1298C gene polymorphisms are related to the TC, Hcy levels in elderly patients with ISH. Plasma Hcy, MTHFR C677T and A1298C gene polymorphisms are the influencing factors of occurrence of ISH in the elderly. |
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