| 毛菊丹·阿扎提,马永华,徐 锐,古丽班努,刘米莉.COPD急性加重期呼气冷凝液中性粒细胞趋化性增加与气道免疫功能障碍的关系[J].现代生物医学进展英文版,2022,(10):1875-1878. |
| COPD急性加重期呼气冷凝液中性粒细胞趋化性增加与气道免疫功能障碍的关系 |
| The Relationship between Increased Chemotaxis of Neutrophils in Expiratory Condensate and Airway Immune Dysfunction during COPD Exacerbation |
| Received:October 09, 2021 Revised:October 31, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.10.016 |
| 中文关键词: 慢性阻塞性肺疾病 呼气冷凝液 中性粒细胞 趋化因子 气道阻力 |
| 英文关键词: Chronic obstructive pulmonary disease Expiratory condensate Neutrophils Chemokines Airway resistance |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2021D01C163） |
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| 中文摘要: |
| 摘要 目的：探讨COPD急性加重期（AECOPD）呼气冷凝液中性粒细胞趋化性增加与气道免疫功能障碍的关系。方法：2018年4月到2021年5月选择在本院诊治的COPD患者88例作为研究对象，包括AECOPD患者48例（急性组）与COPD缓解期患者40例（缓解组），检测两组中性粒细胞氧化吞噬百分率、呼气冷凝液CCL18与CC16含量、外周血T淋巴细胞亚群水平，同时记录气道总粘性阻力、气道总阻抗、近端气道粘性阻力等指标并进行相关性分析。结果：急性组的中性粒细胞氧化吞噬百分率低于缓解组（P<0.05）。急性组的呼气冷凝液CCL18、CC16含量与气道总粘性阻力、气道总阻抗、近端气道粘性阻力高于缓解组（P<0.05）。急性组的CD4+T淋巴细胞比例低于缓解组，CD8+T淋巴细胞高于缓解组（P<0.05）。二分类Logistic回归分析结果显示：中性粒细胞氧化吞噬百分率、气道总阻抗、CD4+T淋巴细胞比例、呼气冷凝液CCL18为导致AECOPD发生的重要因素（P<0.05）。结论：AECOPD患者伴随有呼气冷凝液CCL18、CC16含量增加与中性粒细胞氧化吞噬百分率降低，还伴随有气道阻力增加与免疫功能降低，中性粒细胞氧化吞噬百分率、气道总阻抗、CD4+T淋巴细胞比例、呼气冷凝液CCL18为导致AECOPD发生的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between increased chemotaxis of neutrophils in expiratory condensate and airway immune dysfunction during the acute exacerbation of COPD (AECOPD) period. Methods: From April 2018 to May 2021, 88 cases of COPD patients diagnosed and treated in this hospital were selected as the research objects that included 48 cases of AECOPD patients (acute group) and cases of 40 COPD patients in remission (remission group). The percentage of neutrophil oxidative phagocytosis, expiratory condensate CCL18 and CC16 content, peripheral blood T lymphocyte subgroup levels were detected, and recorded the total airway viscous resistance, total airway resistance, proximal airway viscous resistance and other indicators and given correlation analyzed. Results: The percentage of oxidative phagocytosis of neutrophils in the acute group were lower than that in the remission group (P<0.05). The contents of expiratory condensate CCL18, CC16 and total airway viscous resistance, total airway resistance, proximal airway viscous resistance in the acute group were higher than those in the remission group (P<0.05). The proportion of CD4+T lymphocytes in the acute group were lower than that in the remission group (P<0.05), and the ratio of CD8+T lymphocytes were higher than that in the remission group (P<0.05). The results of binary logistic regression analysis showed that the percentage of neutrophil oxidative phagocytosis, total airway impedance, the proportion of CD4+T lymphocytes, and expiratory condensate CCL18 were important factors leading to the occurrence of AECOPD (P<0.05). Conclusion: Patients with AECOPD are accompanied by increasing in the content of expiratory condensate CCL18 and CC16 and decreasing in the percentage of neutrophil oxidative phagocytosis, as well as increasing in airway resistance and decreasing in immune function, the percentage of neutrophil oxidative phagocytosis, total airway impedance, The ratio of CD4+T lymphocytes and expiratory condensate CCL18 are important factors leading to the occurrence of AECOPD. |
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