| 刚丽丽,曹云松,龙迪和,卢 宝,胡文悦,崔 晓,于 翔,于 宇,韦 伟.柴桂温胆定志汤联合舍曲林对抑郁症患者血清单胺类神经递质和外周血单个核细胞PI3K/Akt信号通路的影响[J].现代生物医学进展英文版,2022,(9):170-1712. |
| 柴桂温胆定志汤联合舍曲林对抑郁症患者血清单胺类神经递质和外周血单个核细胞PI3K/Akt信号通路的影响 |
| Effects of Chaigui Wendan Dingzhi Decoction Combined with Sertraline on Serum Monoamine Neurotransmitters and PI3K/Akt Signal Pathway of Peripheral Blood Mononuclear Cells in Patients with Depression |
| Received:November 04, 2021 Revised:November 27, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.09.022 |
| 中文关键词: 柴桂温胆定志汤 舍曲林 抑郁症 单胺类神经递质 PI3K/Akt信号通路 |
| 英文关键词: Chaigui Wendan Dingzhi decoction Sertraline Depression Monoamine neurotransmitters PI3K/Akt signaling pathway |
| 基金项目:国家重点研发计划项目（SQ2019YFC170218）；北京中医药大学新奥奖励基金（QN2018-08） |
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| 中文摘要: |
| 摘要 目的：观察柴桂温胆定志汤联合舍曲林对抑郁症患者血清单胺类神经递质和外周血单个核细胞磷脂酰肌醇3激酶（PI3K）/蛋白激酶 B（Akt）信号通路的影响。方法：选择2018年10月~2020年6月期间北京市昌平区中西医结合医院收治的抑郁症患者128例，将患者根据信封抽签法分为对照组和实验组，各为64例。对照组患者接受舍曲林治疗，实验组患者接受柴桂温胆定志汤联合舍曲林治疗，观察治疗4周后两组疗效、各量表评分、血清单胺类神经递质和外周血单个核细胞PI3K/Akt信号通路情况，记录两组用药期间不良反应发生情况。结果：实验组的临床总有效率较对照组高（P<0.05）。治疗后，两组生活质量综合评定问卷（GQOLI-74）评分较治疗前升高，且实验组高于对照组（P<0.05）。治疗后，两组匹兹堡睡眠质量指数（PSQI）、汉密尔顿抑郁量表（HAMD）评分较治疗前降低，且实验组低于对照组（P<0.05）。治疗后，两组血清去甲肾上腺素（NE）、5-羟色胺（5-HT）、多巴胺（DA）水平较治疗前升高，且实验组高于对照组（P<0.05）。治疗后，两组PI3K蛋白、Akt蛋白、白介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平较治疗前降低，且实验组低于对照组（P<0.05）。两组不良反应发生率对比无统计学差异（P>0.05）。结论：柴桂温胆定志汤联合舍曲林治疗抑郁症疗效显著，可改善患者睡眠情况，提高生活质量，调节血清单胺类神经递质水平，作用机制可能与调节PI3K/Akt信号通路有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Chaigui Wendan Dingzhi decoction combined with sertraline on serum monoamine neurotransmitters and phosphatidylinositol 3 kinase (PI3K) / protein kinase B (Akt) signal pathway in peripheral blood mononuclear cells of patients with depression. Methods: 128 patients with depression who were treated in Beijing Changping District Hospital of integrated traditional Chinese and Western Medicine from October 2018 to June 2020 were selected, and the patients were divided into control group and experimental group according to the form of envelope lottery, with 64 cases in each group. The patients in the control group were treated with sertraline, and the patients in the experimental group were treated with Chaigui Wendan Dingzhi decoction combined with sertraline. The curative effect, each scale score, serum monoamine neurotransmitters and PI3K/Akt signal pathway of peripheral blood mononuclear cells in the two groups at 4 weeks after treatment were observed, and the adverse reactions during the treatment in the two groups were recorded. Results: The total clinical effective rate of the experimental group was higher than that of the control group (P<0.05). After treatment, the scores of Generic Quality of Life Inventor-74 (GQOLI-74) of the two groups were higher than those before treatment, and the experimental group was higher than the control group(P<0.05). After treatment, the scores of Pittsburgh sleep quality index (PSQI) and Hamilton Depression Scale (HAMD) of the two groups were lower than those before treatment, and the experimental group was lower than the control group(P<0.05). After treatment, the serum norepinephrine (NE), serotonin (5-HT), dopamine (DA) levels of the two groups were higher than those before treatment, and the experimental group was higher than the control group (P<0.05). After treatment, PI3K protein, Akt protein, interleukin-1 β(IL-1β), Tumor necrosis factor-α(TNF-α) levels of two groups were lower than those before treatment, and the experimental group was lower than the control group(P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Chaigui Wendan Dingzhi decoction combined with sertraline is effective in the treatment of depression. It can improve patients' sleep, improve quality of life and regulate the level of serum monoamine neurotransmitters. The mechanism may be related to the regulation of PI3K / Akt signal pathway. |
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