| 罗来斌,徐志敏,黄湖南,戴文鹏,林洪武,王克强,邱卫明,车河龙.吻合器痔上黏膜环切术联合地奥司明对混合痔患者肛肠动力学及血清炎症因子的影响[J].现代生物医学进展英文版,2022,(9):1696-1699. |
| 吻合器痔上黏膜环切术联合地奥司明对混合痔患者肛肠动力学及血清炎症因子的影响 |
| Effects of Procedure for Prolapse and Hemorrhoids Combined with Diosmin on Anorectal Dynamics and Serum Inflammatory Factors in Patients with Mixed Hemorrhoids |
| Received:November 22, 2021 Revised:December 17, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.09.019 |
| 中文关键词: 吻合器痔上黏膜环切术 地奥司明 混合痔 肛肠动力学 炎症因子 |
| 英文关键词: Procedure for prolapse and hemorrhoids Diosmin Mixed hemorrhoids Anorectal dynamics Inflammatory factors |
| 基金项目:江西省卫生计生委科技计划项目（20185555） |
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| 中文摘要: |
| 摘要 目的：探讨吻合器痔上黏膜环切术（PPH）联合地奥司明对混合痔患者肛肠动力学及血清炎症因子的影响。方法：选择2018年5月~2021年5月期间我院收治的混合痔患者115例，随机分为2组：对照组（57例）、观察组（58例），对照组给予PPH治疗，观察组给予PPH联合地奥司明治疗，比较两组疗效、症状评分、肛肠动力学指标及血清炎症因子水平，记录随访期间复发情况。结果：观察组的临床总有效率较对照组高（P<0.05）。观察组术后3个月的直肠感觉阈、直肠耐受量高于对照组，直肠-肛管压力差低于对照组（P<0.05）。观察组术后7 d的血清C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白介素-6（IL-6）水平均低于对照组（P<0.05）。观察组术后3个月的肛周出血评分、 肛缘水肿评分、肛周瘙痒评分均低于对照组（P<0.05）。观察组的复发率较对照组更低（P<0.05）。结论：混合痔患者在PPH术后给予地奥司明治疗，可明显改善术后症状和机体肛肠动力学，并降低血清炎症因子水平，同时还可减少复发率，临床疗效值得肯定。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of procedure for prolapse and hemorrhoids (PPH) combined with Diosmin on anorectal dynamics and serum inflammatory factors in patients with mixed hemorrhoids. Methods: 115 patients with mixed hemorrhoids treated in our hospital from May 2018 to May 2021 were selected, patients were randomly divided into two groups: the control group (57 cases) and the observation group (58 cases). The control group was treated with PPH, and the observation group was treated with PPH combined with Diosmin. The curative effect, symptom score, anorectal dynamics indexes and serum inflammatory factor levels of the two groups were compared, and the recurrence during the follow-up period was recorded. Results: The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). 3 months after operation, the rectal sensory threshold and rectal tolerance of the observation group were higher than those of the control group, and the rectal-anal resting pressure difference was lower than that of the control group (P<0.05). 7 days after operation, the levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) of the observation group were lower than those of the control group(P<0.05). 3 months after operation, the scores of perianal bleeding, pruritus and edema of the observation group were lower than those of the control group(P<0.05). The recurrence rate of the observation group was lower than that of the control group(P<0.05). Conclusion: Diosmin treatment in patients with mixed hemorrhoids after PPH can significantly improve postoperative symptoms and anorectal dynamics, which can reduce the level of inflammatory factors, but also reduce the recurrence rate, the clinical efficacy is worthy of affirmation. |
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