| 霍风文,张俊艳,张德重,金 翠,韩中斌.血清APN、PGRN联合检测对脓毒症患儿疾病的预测价值及与其预后的相关性分析[J].现代生物医学进展英文版,2022,(8):1596-1600. |
| 血清APN、PGRN联合检测对脓毒症患儿疾病的预测价值及与其预后的相关性分析 |
| Predictive Value of Combined Detection of Serum APN and PGRN in Children with Sepsis and Its Correlation Analysis with Its Prognosis |
| Received:September 22, 2021 Revised:October 17, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.08.041 |
| 中文关键词: 脂联素 颗粒体上皮蛋白前体 脓毒症 预后 |
| 英文关键词: Adiponectin Progranulin Sepsis Prognosis |
| 基金项目:山西省卫生和计划生育委员会科研项目（2017182） |
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| 中文摘要: |
| 摘要 目的：研究脂联素（APN）和颗粒体上皮蛋白前体（PGRN）在脓毒症患儿血清中的变化，并探讨其临床意义。方法：纳入2019年1月到2021年6月在我院接受治疗的脓毒症患儿90例，并纳入同期在我院进行体检的健康儿童30例作为对照组。根据脓毒症患儿预后将其分为存活组（n=67）和死亡组（n=23）。采集所有研究对象外周血，通过酶联免疫吸附剂测定测定血清APN、PGRN、肿瘤坏死因子α（TNF-α）、白介素1β（IL-1β）、C-反应蛋白（CRP）和降钙素原（PCT）。分析血清APN、PGRN与脓毒症患儿血清炎症因子、疾病严重程度的相关性。结果：脓毒症患儿血清APN、PGRN均显著低于对照组健康儿童（P<0.05）。在脓毒症患儿中，血清APN、PGRN与血清TNF-α、IL-1β、CRP以及PCR含量均呈负相关（P<0.05）。存活组脓毒症患儿血清APN、PGRN以及小儿危重病例评分（PCIS）均显著高于死亡组脓毒症患儿（P<0.05），并且脓毒症患儿血清APN、PGRN与PCIS评分呈正相关。多因素Logstic回归分析结果显示：小儿危重病例评分表（PCIS）评分（OR=2.691，95%CI=1.052-4.352）、血清APN（OR=3.026，95%CI=1.628-4.692）和PGRN（OR=2.824，95%CI=1.328-6.824）水平均是影响脓毒症患儿预后的独立危险因素（P<0.05）。结论：脓毒症患儿血清APN、PGRN均显著降低，其含量与脓毒症疾病严重程度和外周血炎症反应具有相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To study the changes of adiponectin (APN) and progranulin (PGRN) in the serum of children with sepsis, and explore their clinical significance. Methods: 90 children with sepsis who were treated in our hospital from January 2019 to June 2021 were included, and 30 healthy children who underwent physical examinations in our hospital during the same period were included as a control group. According to the prognosis of sepsis children, they were divided into survival group (n=67) and death group (n=23). Peripheral blood of all research subjects was collected, and serum APN, PGRN, tumor necrosis factor α(TNF-α), interleukin 1β (IL-1β), C-reactive protein (CRP) and procalcitonin were determined by enzyme-linked immunosorbent assay (PCT). Analyze the correlation between serum APN, PGRN and serum inflammatory factors and disease severity in children with sepsis. Results: Serum APN and PGRN of children with sepsis were lower than those of healthy children in the control group(P<0.05). In children with sepsis, serum APN, PGRN and serum TNF-α, IL-1β, CRP and PCR levels were negatively correlated(P<0.05). Serum APN, PGRN, and Pediatric Critical Case Score(PCIS) of children with sepsis in the survival group were higher than those in the death group with sepsis(P<0.05), and the serum APN, PGRN, and PCIS scores of children with sepsis were positive Related. The results of multivariate Logstic regression analysis showed: PCIS score(OR=2.691, 95%CI=1.052-4.352), serum APN(OR=3.026, 95%CI=1.628-4.692) and PGRN (OR=2.824, 95%CI=1.328-6.824) level is an independent risk factor affecting the prognosis of children with sepsis (P<0.05). Conclusion: Serum APN and PGRN in children with sepsis were significantly reduced, and their levels were related to the severity of sepsis and peripheral blood inflammation. |
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