| 庞晓丽,陈华军,高琳琳,刘志锋,黄维曦.非小细胞肺癌患者术后抑郁状况的影响因素及与生存质量和睡眠质量的相关性研究[J].现代生物医学进展英文版,2022,(8):1567-1572. |
| 非小细胞肺癌患者术后抑郁状况的影响因素及与生存质量和睡眠质量的相关性研究 |
| Influence Factors of Postoperative Depression in Patients with Non-Small Cell Lung Cancer and its Correlation with Quality of Life and Sleep Quality |
| Received:September 02, 2021 Revised:September 25, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.08.035 |
| 中文关键词: NSCLC 抑郁 影响因素 生存质量 睡眠质量 相关性 |
| 英文关键词: NSCLC Depression Influence factors Quality of life Sleep quality Correlation |
| 基金项目:广东省医学科学技术研究基金项目（B201800643） |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌（NSCLC）患者术后抑郁状况的影响因素，分析术后抑郁与生存质量和睡眠质量的关系。方法：选取2019年1月～2021年1月在韶关市第一人民医院胸外科行手术治疗的 80例NSCLC患者，采用抑郁自评量表（SDS）评估其术后抑郁情况，根据评估结果将患者分为抑郁组（SDS评分≥50分，33例）和非抑郁组（SDS评分＜50分，47例），单因素及多因素Logistic回归分析NSCLC患者术后抑郁的影响因素。采用肺癌患者生存质量测定量表（FACT-L）中文版（V4.0）、匹兹堡睡眠质量指数量表（PSQI）测评所有患者的生存质量和睡眠质量，Pearson相关性分析SDS评分与FACT-L、PSQI评分之间的关系。结果：抑郁组与非抑郁组间年龄、性别、文化程度、家庭收入水平、医疗费用支付方式、生活能否自理、肺癌TNM分期、术后是否并发肺炎有明显差异（P＜0.05）。进一步多因素分析显示，术后并发肺炎、肺癌TNM分期Ⅲ期、女性、大专以下文化程度是NSCLC患者术后抑郁的危险因素（P＜0.05）。抑郁组FACT-L评分低于非抑郁组，PSQI评分高于非抑郁组（P＜0.05）。SDS评分与FACT-L评分呈负相关，与PSQI评分呈正相关（P＜0.05）。结论：术后并发肺炎、肺癌TNM分期Ⅲ期、女性、文化程度低是影响NSCLC患者术后抑郁的因素，术后抑郁的发生会降低患者的生存质量和睡眠质量。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the influencing factors of postoperative depression in patients with non-small cell lung cancer (NSCLC), and to analyze the relationship between postoperative depression and quality of life and sleep quality. Methods: 80 patients with NSCLC who were undergoing surgical treatment in our hospital from January 2019 to January 2021 were selected, the postoperative depression was assessed by self rating Depression Scale (SDS). According to the evaluation results, the patients were divided into depression group (SDS score≥50 scores, 33 cases) and non-depression group (SDS score＜50 scores, 47 cases), univariate analysis and multivariate Logistic regression analysis were used to analyze the influencing factors of postoperative depression in patients with NSCLC. Functional assessment of cancer therapy-lung (FACT-L) Chinese version (V4.0) and Pittsburgh sleep quality index scale (PSQI) were used to evaluate the quality of life and sleep of patients, and Pearson correlation analysis was used to analyze the correlation between SDS score and FACT-L and PSQI score. Results: There were significant differences between the depression group and the non-depression group in age, gender, education level, family income level, payment mode of medical expenses, self-care ability, lung cancer TNM stage and postoperative pneumonia (P<0.05). Further multivariate analysis showed that postoperative pneumonia, lung cancer TNM stage Ⅲ, female, education below junior college were the risk factors of postoperative depression in patients with NSCLC(P<0.05). FACT-L score in depression group was lower than that in non-depression group, and PSQI score was higher than that in non-depression group (P<0.05). SDS score was negatively correlated with FACT-L score, and positively correlated with PSQI score (P<0.05). Conclusion: Postoperative complications of pneumonia, lung cancer TNM stage Ⅲ, female, low educational level are the influence factors postoperative depression in patients with NSCLC, and the occurrence of postoperative depression can reduces the quality of life and sleep quality of patients. |
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