| 赵 涵,朱颖炜,王 雷,龚 镭,宣佳磊,许文慧.血浆PLSCR1、PTX3、SALL4与肝细胞癌患者临床病理参数的关系及联合检测的辅助诊断价值研究[J].现代生物医学进展英文版,2022,(8):1524-1528. |
| 血浆PLSCR1、PTX3、SALL4与肝细胞癌患者临床病理参数的关系及联合检测的辅助诊断价值研究 |
| Relationship between Serum PLSCR1, PTX3 and SALL4 and Clinicopathological Parameters of Patients with Hepatocellular Carcinoma and the Auxiliary Diagnostic Value of Combined Detection |
| Received:September 06, 2021 Revised:September 28, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.08.026 |
| 中文关键词: 肝细胞癌 PLSCR1 PTX3 SALL4 临床病理参数 诊断价值 |
| 英文关键词: Hepatocellular carcinoma PLSCR1 PTX3 SALL4 Clinicopathological parameters Diagnostic value |
| 基金项目:江苏省自然科学基金面上项目（BK20181129）；江苏省无锡市"双百"中青年医疗卫生拔尖人才项目（BJ2020027） |
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| 中文摘要: |
| 摘要 目的：探讨血浆磷脂爬行酶1（PLSCR1）、正五聚蛋白3（PTX3）、spalt样转录因子4（SALL4）与肝细胞癌（HCC）患者临床病理参数的关系及联合检测的辅助诊断价值。方法：纳入2020年1月～2021年12月南京医科大学附属无锡第二医院收治的94例HCC患者（HCC组）、67例肝硬化患者（肝硬化组）、78例慢性乙型肝炎患者（慢性乙型肝炎组），另取同期健康体检者58例为对照组，检测并对比四组血浆PLSCR1、PTX3、SALL4及血清甲胎蛋白（AFP）水平。分析血浆PLSCR1、PTX3、SALL4水平与HCC患者临床病理参数的关系。采用受试者工作特征（ROC）曲线分析血清AFP联合血浆PLSCR1、PTX3、SALL4对HCC的辅助诊断价值。结果：HCC组血浆PLSCR1、PTX3、SALL4、血清AFP水平高于肝硬化组、慢性乙型肝炎组以及对照组，肝硬化组上述指标水平高于慢性乙型肝炎组和对照组，慢性乙型肝炎组上述指标水平高于对照组（P＜0.05）。不同分化程度、Child-Pugh分级、巴塞罗那临床肝癌（BCLC）分期、淋巴结转移HCC患者血浆PLSCR1、PTX3、SALL4水平比较，差异有统计学意义（P＜0.05）。ROC曲线分析结果显示，血清AFP、血浆PLSCR1、PTX3、SALL4四项联合检测诊断HCC的曲线下面积（AUC）为0.923，明显高于血浆PLSCR1、PTX3、SALL4三项联合检测以及各指标单独检测（P＜0.05）。结论：HCC患者血浆PLSCR1、PTX3、SALL4水平呈高表达，与分化程度、Child-Pugh分级、BCLC分期和淋巴结转移有关，可作为HCC早期诊断的辅助指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum phospholipid scramblase 1(PLSCR1), pentraxin 3 (PTX3) and spalt-like transcription factor 4 (SALL4) and clinicopathological parameters of patients with hepatocellular carcinoma and the auxiliary diagnostic value of combined detection. Methods: 94 patients with HCC(HCC group), 67 patients with cirrhosis (cirrhosis group) and 78 patients with chronic hepatitis B (chronic hepatitis B group) who were admitted to Wuxi Second Hospital Affiliated to Nanjing Medical University from January 2020 to December 2021 were included, and another 58 patients with healthy physical examination at the same period were taken as the control group. Plasma levels of PLSCR1, PTX3, SALL4 and serum alpha-fetoprotein (AFP) were measured and compared among the four groups. The relationship between plasma PLSCR1, PTX3 and SALL4 levels and clinicopathological parameters in patients with HCC were analyzed. Receiver operating characteristic(ROC) curve was used to analyze the auxiliary diagnostic value of serum AFP combined with plasma PLSCR1, PTX3 and SALL4 for HCC. Results: The levels of plasma PLSCR1, PTX3, SALL4 and serum AFP in the HCC group were higher than those in the cirrhosis group, the chronic hepatitis B group and the control group, and the levels of the above indicators in the cirrhosis group were higher than those in the chronic hepatitis B group and the control group, and the levels of the above indicators in the chronic hepatitis B group were higher than those in the control group(P＜0.05). Comparison of levels of plasma PLSCR1, PTX3 and SALL4 in patients with different degrees of differentiation, Child-Pugh classification, Barcelona Clinical Liver Cancer (BCLC) stage and lymph node metastasis HCC showed statistically significant differences(P＜0.05). The ROC curve analysis showed that the area under the curve (AUC) of the combined detection of serum AFP, plasma PLSCR1, PTX3 and SALL4 for the diagnosis of HCC was 0.923, which was significantly higher than the combined detection of plasma PLSCR1, PTX3 and SALL4 and each indicator alone(P＜0.05). Conclusion: Plasma levels of PLSCR1, PTX3 and SALL4 are highly expressed in patients with HCC, which are associated with the degree of differentiation, Child-Pugh classification, BCLC stage and lymph node metastasis, and which could be used as an auxiliary indicator for early diagnosis of HCC. |
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