| 李 雯,王小玲,史蓓洁,朱子军,陈 丽,王琲艳,袁亦杰,张伟伟.上海市杨浦区社区2型糖尿病患者周围神经病变患病率调查及其影响因素分析[J].现代生物医学进展英文版,2022,(8):1461-1465. |
| 上海市杨浦区社区2型糖尿病患者周围神经病变患病率调查及其影响因素分析 |
| Prevalence Investigate and Influencing Factors of Peripheral Neuropathy in Community Patients with Type 2 Diabetes Mellitus in Yangpu District of Shanghai |
| Received:October 06, 2021 Revised:October 28, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.08.012 |
| 中文关键词: 2型糖尿病 周围神经病变 患病率 影响因素 |
| 英文关键词: Type 2 diabetes mellitus Peripheral neuropathy Prevalence Influencing factors |
| 基金项目:上海市卫生和计划生育委员会项目（201740173） |
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| 中文摘要: |
| 摘要 目的：调查上海市杨浦区社区2型糖尿病（T2DM）患者周围神经病变（DPN）患病率，并分析其影响因素。方法：于2019年3月~2020年3月在上海市杨浦区所辖社区中随机选取5个社区，采用分层随机抽样法从每个社区选取100例T2DM患者进行调查，统计T2DM患者DPN患病率，采用多因素Logistic回归分析DPN发生的影响因素。结果：本次研究共发放500份调查问卷，回收498份，回收率为99.60%（498/500），其中DPN患者222例，DPN发生率为44.58%（222/498），纳为DPN组，276例未发生DPN纳为非DPN组。单因素分析结果显示：DPN组与非DPN组在腰围、合并糖尿病视网膜病变（DR）、合并下肢血管病变（PVD）、吸烟史、高血压、脑梗死病史、文化程度、婚姻状况、收缩压（SBP）、空腹血糖（FPG）、葡萄糖达标时间百分比（TIR）、载脂蛋白B、尿酸方面比较有差异（P<0.05）。进一步多因素Logistic回归分析结果显示：合并DR、合并PVD、有吸烟史、有脑梗死病史、婚姻状况为未婚/离异/丧偶、FPG水平较高是T2DM患者发生DPN的危险因素（P<0.05）。结论：T2DM患者中DPN的患病率较高，合并DR、PVD、吸烟史、脑梗死病史以及婚姻状况是DPN发生的影响因素，应重视DPN筛查并进行干预，针对上述影响因素对T2DM患者开展健康宣教，减少DPN的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the prevalence of peripheral neuropathy (DPN) in community patients with type 2 diabetes mellitus (T2DM) in Yangpu District of Shanghai, and to analyze its influencing factors. Methods: From March 2019 to March 2020, five communities were randomly selected from the communities under the jurisdiction of Yangpu District, Shanghai. 100 patients with T2DM were selected from each community by stratified random sampling. The prevalence of DPN in patients with T2DM was counted, and the influencing factors of DPN were analyzed by multivariate logistic regression. Results: Univariate analysis results showed that there were differences between DPN group and non DPN group in waistline, combined diabetic retinopathy (DR), combined peripheral vascular disease(PVD), smoking history, hypertension, history of cerebral infarction, education level, marital status, systolic blood pressure (SBP), fasting blood glucose (FPG), time in range (TIR), apolipoprotein B and lithic acid (P<0.05). Further multivariate logistic regression analysis showed that combined DR, combined PVD, have a history of smoking, have a history of cerebral infarction, unmarried/divorced/widowed marital status and higher FPG level were the risk factors of DPN in T2DM patients (P<0.05). Conclusion: The prevalence of DPN is high in patients with T2DM, combined with DR, PVD, smoking history, cerebral infarction history and marital status are the influencing factors of DPN, we should pay attention to DPN screening and intervention, and carry out health education for T2DM patients according to the above influencing factors to reduce the occurrence of DPN. |
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