| 李 静,覃腊云,欧阳辉,吴 杰,章 婵.序贯肠内外营养支持对AECOPD合并呼吸衰竭患者营养指标、胃肠黏膜功能和免疫功能的影响[J].现代生物医学进展英文版,2022,(7):1333-1337. |
| 序贯肠内外营养支持对AECOPD合并呼吸衰竭患者营养指标、胃肠黏膜功能和免疫功能的影响 |
| Effects of Sequential Parenteral Nutrition Support on Nutritional Indicators, Gastrointestinal Mucosal Function and Immune Function in Patients with AECOPD Complicated with Respiratory Failure |
| Received:August 27, 2021 Revised:September 23, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.07.029 |
| 中文关键词: 慢性阻塞性肺疾病 呼吸衰竭 营养支持 营养指标 免疫功能 胃肠黏膜功能 |
| 英文关键词: Chronic obstructive pulmonary disease Respiratory failure Nutrition support Nutritional indicators Immune function Gastrointestinal mucosal function |
| 基金项目:湖南省卫生计生委科研计划项目（B20180479） |
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| 中文摘要: |
| 摘要 目的：观察序贯肠内外营养支持在慢性阻塞性肺疾病急性加重期（AECOPD）合并呼吸衰竭患者中的应用价值。方法：选用随机数字表法将我院2019年1月-2020年12月期间收治的90例AECOPD合并呼吸衰竭患者分为肠内组（n=30）、肠外组（n=30）和序贯组（n=30）。对比三组患者营养指标、胃肠黏膜功能和免疫功能，观察并记录三组抗菌药物使用天数、住院天数和并发症发生率。结果：序贯组的抗菌药物使用天数、住院天数短于肠内组、肠外组（P<0.05）。序贯组营养支持2周后白蛋白（ALB）、前白蛋白（PA）、转铁蛋白（TF）均高于肠内组、肠外组（P<0.05）。序贯组营养支持2周后免疫球蛋白（Ig）A、IgM、IgG均高于肠内组、肠外组（P<0.05）。序贯组营养支持2周后D-乳酸、二胺氧化酶（DAO）均低于肠内组、肠外组（P<0.05）。三组并发症发生率组间对比无明显差异（P>0.05）。结论：序贯肠内外营养支持应用于AECOPD合并呼吸衰竭患者，可促进患者免疫功能提高，营养状况改善，同时还可促进胃肠黏膜功能恢复，缩短抗菌药物使用天数和住院天数。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the value of sequential parenteral nutrition support in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure. Methods: Using random number table method, 90 patients with AECOPD complicated with respiratory failure who were treated in our hospital from January 2019 to December 2020 were randomly divided into enteral group (n=30), parenteral group (n=30) and sequential group (n=30). The nutritional indicators, gastrointestinal mucosal function and immune function of the three groups were compared. The days of use of antibiotics, the days of hospitalization and the incidence of complications of the three groups were observed and recorded. Results: The days of use of antibiotics, the days of hospitalization in sequential group were shorter than those in enteral group and parenteral group (P<0.05). 2 weeks after nutritional support, albumin (ALB), prealbumin (PA) and transferrin (TF) in sequential group were higher than those in enteral group and parenteral group (P<0.05). 2 weeks after nutritional support, the immunoglobulin (Ig)A, IgM and IgG in the sequential group were higher than those in the enteral group and the parenteral group (P<0.05). 2 weeks after nutritional support, D-lactate and diamine oxidase (DAO) in sequential group were lower than those in enteral group and parenteral group (P<0.05). There was no significant difference in the incidence of complications among the three groups (P>0.05). Conclusion: Sequential enteral and parenteral nutrition support in patients with AECOPD complicated with respiratory failure can improve their immune function, improve their nutritional status, promote the recovery of gastrointestinal mucosal function, and shorten the days of use of antibiotics and the days of hospitalization. |
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