| 张海龙,刘育鹏,唐庆龙,王 庆,刘 燕.血清Copeptin、suPAR、SIRT1与慢性心力衰竭患者心功能及短期预后的关系研究[J].现代生物医学进展英文版,2022,(7):1262-1266. |
| 血清Copeptin、suPAR、SIRT1与慢性心力衰竭患者心功能及短期预后的关系研究 |
| Relationship Research between Serum Copeptin, suPAR, SIRT1 and Cardiac Function and Short-Term Prognosis in Patients with Chronic Heart Failure |
| Received:August 31, 2021 Revised:September 26, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.07.014 |
| 中文关键词: 慢性心力衰竭 Copeptin suPAR SIRT1 心功能 预后 危险因素 |
| 英文关键词: Chronic heart failure Copeptin suPAR SIRT1 Cardiac function Prognosis Risk factors |
| 基金项目:北京市自然科学基金项目（7192192） |
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| 中文摘要: |
| 摘要 目的：研究血清和肽素（Copeptin）、可溶性尿激酶型纤溶酶原激活物受体（suPAR）、沉默信息调节因子2相关酶1（SIRT1）与慢性心力衰竭（CHF）患者心功能及短期预后的关系。方法：选取我院2018年2月～2020年2月收治的175例CHF患者，将其按照美国纽约心功能（NYHA）分级的差异分作Ⅱ级组56例，Ⅲ级组62例，Ⅳ级组57例。另取我院同期健康体检人员50例作为对照组。比较各组血清Copeptin、suPAR、SIRT1水平及心功能指标，并进行相关性分析。此外，对所有CHF患者进行为期1年的随访，按照预后差异分作预后不良组61例及预后良好组114例。以单因素、多因素Logistic回归分析CHF患者预后的影响因素。结果：与对照组相比，CHF患者的血清Copeptin、suPAR水平及左心室舒张末期内径（LVEDD）升高，而SIRT1水平及左心室射血分数（LVEF）降低（P＜0.05）；不同心功能等级的CHF患者间比较，随着心衰程度的加重，血清Copeptin、suPAR水平及LVEDD升高，而SIRT1水平及LVEF降低（P＜0.05）。Pearson相关性分析结果显示，CHF患者血清Copeptin、suPAR水平与LVEDD均呈正相关，而与LVEF呈负相关（P＜0.05）；血清SIRT1水平与LVEDD呈负相关，而与LVEF呈正相关（P＜0.05）。单因素分析结果显示，预后不良组年龄、LVEDD、血清Copeptin、suPAR水平均高于预后良好组，而LVEF和SIRT1水平低于预后良好组（P＜0.05）。多因素Logistic回归分析结果显示，年龄偏大、LVEDD偏高、LVEF偏低、血清Copeptin、suPAR水平过高以及血清SIRT1水平过低均是CHF患者短期预后不良的危险因素（P＜0.05）。结论：血清Copeptin、suPAR、SIRT1与CHF患者的心功能及短期预后密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum Copeptin (Copeptin), soluble urokinase-type plasminogen activator receptor (suPAR), silent information regulator factor 2 related enzyme 1 (SIRT1) and cardiac function and short-term prognosis in patients with chronic heart failure (CHF). Methods: 175 patients with CHF who were admitted to our hospital from February 2018 to February 2020 were selected. According to the New York Heart function (NYHA) classification, they were divided into grade II group with 56 cases, grade III group with 62 cases and grade IV group with 57 cases. Another 50 cases of physical examination personnel in our hospital in the same period were taken as the control group. The serum Copeptin, suPAR, SIRT1 levels and cardiac function indexes were detected and compared in each group, and correlation analysis was conducted. In addition, all patients with CHF were followed up for 1 year, and divided into poor prognosis group with 61 cases and good prognosis group with 114 cases. The influencing factors of prognosis in patients with CHF were analyzed by univariate and multivariate Logistic regression. Results: Compared with the control group, the serum Copeptin, suPAR levels and left ventricular end diastolic diameter (LVEDD) increased, while the SIRT1 level and left ventricular ejection fraction (LVEF) decreased (P＜0.05). With the aggravation of heart failure, the serum Copeptin, suPAR levels and LVEDD were increased, while the SIRT1 level and LVEF were decreased in patients with CHF with different levels of heart function (P＜0.05). Pearson correlation analysis showed that the serum Copeptin and suPAR levels were positively correlated with LVEDD in patients with CHF, but negatively correlated with LVEF (P＜0.05). The serum SIRT1 level was negatively correlated with LVEDD, but positively correlated with LVEF (P＜0.05). Univariate analysis showed that age, LVEDD, the serum Copeptin and suPAR levels in the poor prognosis group were higher than those in the good prognosis group, while LVEF and SIRT1 levels were lower than those in the good prognosis group (P＜0.05). Multivariate Logistic regression analysis showed that older age, higher LVEDD, lower LVEF, higher serum Copeptin and suPAR levels and lower serum SIRT1 level were all risk factors for poor short-term prognosis of patients with CHF (P＜0.05). Conclusion: Serum Copeptin, suPAR and SIRT1 are closely related to cardiac function and short-term prognosis of patients with CHF. |
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