| 王瑞习,韩 梅,郑彦茹,李 磊,徐 静,陆集芬.胺碘酮与普罗帕酮在快速性心律失常患者院前急救效果中的对比研究[J].现代生物医学进展英文版,2022,(6):1156-1159. |
| 胺碘酮与普罗帕酮在快速性心律失常患者院前急救效果中的对比研究 |
| Comparative Study of Amiodarone and Propafenone in Prehospital Emergency Treatment of Patients with Tachyarrhythmia |
| Received:July 27, 2021 Revised:August 23, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.06.033 |
| 中文关键词: 胺碘酮 普罗帕酮 快速性心律失常 院前急救 心功能 炎症因子 心肌损伤 |
| 英文关键词: Amiodarone Propafenone Tachyarrhythmia Prehospital emergency Cardiac function Inflammatory factors Myocardial injury |
| 基金项目:石家庄市科学技术研究与发展计划项目（191460613）；河北省重点研发计划自筹项目（172777161） |
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| 中文摘要: |
| 摘要 目的：对比胺碘酮与普罗帕酮在快速性心律失常患者院前急救中的临床效果。方法：将石家庄市急救中心 2019年 4月~2021年 2月期间院前急救时现场治疗的快速性心律失常患者（n=108）按照随机数字表法分为对照组（n=54）和观察组（n=54）。对照组接受普罗帕酮治疗，观察组接受胺碘酮治疗，比较两组心功能、血压、心率（HR）、炎症因子指标、心肌损伤指标及不良反应发生率。结果：治疗结束后，观察组左心室射血分数（LVEF）、心输血量（CO）、二尖瓣舒张早期 /晚期峰值流速（E/A）均高于对照组（P<0.05）。治疗结束后，观察组收缩压（SBP）、舒张压（DBP）、HR均低于对照组（P<0.05）。治疗结束后，观察组肿瘤坏死因子 -α（TNF-α）和白介素 -6（IL-6）水平均低于对照组（P<0.05）。治疗结束后，观察组心肌肌钙蛋白Ⅰ（cTnI）、脑钠肽（BNP）、肌酸激酶同工酶（CK-MB）水平均低于对照组（P<0.05）。两组不良反应发生率组间对比无统计学差异（P>0.05）。结论：在快速性心律失常患者院前急救中，相比于普罗帕酮，胺碘酮可有效改善患者心功能，减少心肌损伤，恢复血压并改善 HR，减轻炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the clinical effect of amiodarone and propafenone in prehospital emergency of patients with tachyarrhythmia. Methods: Patients with tachyarrhythmia (n=108) who received on-site prehospital emergency treatment in Shijiazhuang Emergency Center from April 2019 to February 2021 were divided into control group (n=54) and observation group (n=54) according to random number table method. The control group was treated with propafenone, and the observation group was treated with amiodarone. The Cardiac function, blood pressure, heart rate (HR), inflammatory factors indexes, myocardial injury indexes and adverse reaction rate of the two groups were compared. Results: After treatment, the left ventricular ejection fraction (LVEF), cardiac transfusion volume (CO) and early/late mitral diastolic peak flow rate (E/A) of the observation group were higher than those of the control group (P<0.05). After treatment, the systolic blood pressure (SBP), diastolic blood pressure(DBP) and HR of the observation group were lower than those of the control group (P<0.05). After treatment, the levels of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) of the observation group were lower than those of the control group (P<0.05). After treatment, the levels of cardiac Troponin-1 (cTnI), brain natriuretic peptide (BNP) and creatine kinase isoenzyme (CK-MB) of the observation group were lower than those of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: In the prehospital emergency treatment of patients with tachycardia, compared with propafenone, amiodarone can effectively improve cardiac function, reduce myocardial injury, restore blood pressure, improve HR and reduce inflammatory reaction. |
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